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Parkinson’s Disease and Sleep/Wake Disturbances

  • Todd J. Swick
  • William G. Ondo
Chapter

Abstract

Parkinson’s disease (PD) has traditionally been characterized by its cardinal motor symptoms of bradykinesia, rigidity, resting tremor, and postural instability. However, PD is increasingly recognized as a multidimensional disease associated with myriad non-motor symptoms including autonomic dysfunction, mood disorders, cognitive impairment, pain, gastrointestinal disturbance, impaired olfaction, psychosis, and sleep disorders. Sleep disturbances, which include sleep fragmentation, daytime somnolence, sleep-disordered breathing, restless legs syndrome (RLS), nightmares, and rapid eye movement (REM) sleep behavior disorder (RBD), are estimated to occur in 60–98 % of patients with PD. For years, non-motor symptoms received little attention from clinicians and researchers but now these symptoms are known to be significant predictors of morbidity, quality of life, costs of disease, and rates of institutionalization. A discussion of the clinical aspects, pathophysiology, evaluation techniques and treatment options for sleep disorders encountered with PD are presented.

Keywords

Non-motor Pathophysiology Synuclein Sleep disorders Dopamine 

References

  1. Aarsland D, Larsen J, Tandberg E et al (2000) Predictors of nursing home placement in Parkinson’s disease: a population-based, prospective study. J Am Geriatr Soc 48(8):938–942PubMedCrossRefGoogle Scholar
  2. Abbott R, Ross G, White L et al (2005) Excessive daytime sleepiness and subsequent development of Parkinson’s disease. Neurology 65:1442–1446Google Scholar
  3. Abe K, Hikita T, Sakoda S (2005) A hypnotic drug for sleep disturbances in patients with Parkinson’s disease. Brain Nerve 57(4):301–305PubMedGoogle Scholar
  4. Adler CH, Caviness JN, Hentz JG, Lind M, Tiede J (2003) Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson’s disease. Mov Disord 18(3):287–293. doi: 10.1002/mds.10390 PubMedCrossRefGoogle Scholar
  5. Albin R, Koeppe R, Bohnen N et al (2008) Spared caudal brainstem SERT binding in early Parkinson’s disease. J Cereb Blood Flow Metab 28:441–444PubMedCrossRefGoogle Scholar
  6. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4(2):101–119PubMedCrossRefGoogle Scholar
  7. Amara AW, Watts RL, Walker HC (2011) The effects of deep brain stimulation on sleep in Parkinson’s disease. Ther Adv Neurol Disord 4(1):15–24. doi: 10.1177/1756285610392446 PubMedPubMedCentralCrossRefGoogle Scholar
  8. Amara AW, Standaert DG, Guthrie S, Cutter G, Watts RL, Walker HC (2012) Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson’s disease. Parkinsonism Relat Disord 18(1):63–68. doi: 10.1016/j.parkreldis.2011.09.001 PubMedCrossRefGoogle Scholar
  9. American Academy of Sleep Medicine (2014) International classification of sleep disorders, 3rd edn. American Academy of Sleep Medicine, Darien, ILGoogle Scholar
  10. Anderson KN, Shneerson JM (2009) Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J Clin Sleep Med: JCSM: official publication of the American Academy of Sleep Medicine 5(3):235–239Google Scholar
  11. Arand D, Bonnet M, Hurwitz T, Mitler M, Rosa R, Sangal R (2005) The clinical use of the MSLT and MWT. Sleep 28(1):123–144PubMedGoogle Scholar
  12. Armstrong D, Saper C, Levey A et al (1983) Distribution of cholinergic neurons in rat brain: demonstrated by the immunocytochemical localization of choline acetyltransferase. J Comp Neurol 216:53–68PubMedCrossRefGoogle Scholar
  13. Arnulf I (2005) Excessive daytime sleepiness in parkinsonism. Sleep Med Rev 9(3):185–200PubMedCrossRefGoogle Scholar
  14. Arnulf I, Morgan J (2011) Not all that goes “bump in the night” is RLS. Leg motor restlessness in PD. Neurology 77:1936–1937PubMedCrossRefGoogle Scholar
  15. Arnulf I, Bonnet A, Damier P et al (2000) Hallucinations, REM sleep and Parkinson’s disease: a medical hypothesis. Neurology 55:281–288PubMedCrossRefGoogle Scholar
  16. Arnulf I, Konofal E, Merino-Andreu M et al (2002) Parkinson’s disease and sleepiness. An integral part of PD. Neurology 58:1019–1024PubMedCrossRefGoogle Scholar
  17. Arnulf I, Merino-Andreu M, Bloch F et al (2005) REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep 28(3):349–354PubMedGoogle Scholar
  18. Bamford C (1993) Carbamazepine in REM sleep behavior disorder. Sleep 16(1):33–34PubMedGoogle Scholar
  19. Barone P, Antonini A, Colosimo C et al (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24(11):1641–1649PubMedCrossRefGoogle Scholar
  20. Berry R, Brooks R, Gamaldo C, Harding S, Lloyd R, Marcus C, Vaughn B (2015) The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, vol 2.2. American Academy of Sleep Medicine, DarienGoogle Scholar
  21. Boeve B, Silber M, Ferman T (2001) Current management of sleep disturbances in dementia. Cur Neurol Neurosci Reports 2:169–177CrossRefGoogle Scholar
  22. Boeve B, Silber M, Ferman T (2003) Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med 4(4):281–284PubMedCrossRefGoogle Scholar
  23. Boeve B, Silber M, CB S, Ferman T, Dickson D, Parisi J, Benarroch E, Ahlskog J, Smith G, Caselli R, Tippmann-Peikert M, Olson E, Lin S, Young T, Wszolek Z, Schenck C, Mahowald M, Castillo P, Tredici K, Braak H (2007) Pathophysiology of REM sleep behavior disorder and relevance to neurodegenerative disease. Brain 130:2770–2788Google Scholar
  24. Boeve BF, Silber MH, Ferman TJ, Lin SC, Benarroch EE, Schmeichel AM, Ahlskog JE, Caselli RJ, Jacobson S, Sabbagh M, Adler C, Woodruff B, Beach TG, Iranzo A, Gelpi E, Santamaria J, Tolosa E, Singer C, Mash DC, Luca C, Arnulf I, Duyckaerts C, Schenck CH, Mahowald MW, Dauvilliers Y, Graff-Radford NR, Wszolek ZK, Parisi JE, Dugger B, Murray ME, Dickson DW (2013) Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med 14(8):754–762. doi: 10.1016/j.sleep.2012.10.015 PubMedPubMedCentralCrossRefGoogle Scholar
  25. Boissard R, Gervasoni D, Schmidt M et al (2002) The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomy study. Eur J Neurosci 16:1959–1973Google Scholar
  26. Boissard R, Fort P, Gervasoni D et al (2003) Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur J Neurosci 18(6):1627–1639PubMedCrossRefGoogle Scholar
  27. Braak H, Del Tredici K, Rub U et al (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurbiol Aging 24(2):197–211CrossRefGoogle Scholar
  28. Bridoux A, Moutereau S, Covali-Noroc A, Margarit L, Palfi S, Nguyen JP, Lefaucheur JP, Cesaro P, d’Ortho MP, Drouot X (2013) Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson’s disease. Nat Sci Sleep 5:87–91. doi: 10.2147/NSS.S41245 PubMedPubMedCentralCrossRefGoogle Scholar
  29. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW (2012) Control of sleep and wakefulness. Physiol Rev 92(3):1087–1187. doi: 10.1152/physrev.00032.2011 PubMedPubMedCentralCrossRefGoogle Scholar
  30. Cai Y, Liu S, Sothern RB, Xu S, Chan P (2010) Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease. Eur J Neurol 17(4):550–554. doi: 10.1111/j.1468-1331.2009.02848.x PubMedCrossRefGoogle Scholar
  31. Chahine LM, Daley J, Horn S, Duda JE, Colcher A, Hurtig H, Cantor C, Dahodwala N (2013) Association between dopaminergic medications and nocturnal sleep in early-stage Parkinson’s disease. Parkinsonism Relat Disord 19(10):859–863. doi: 10.1016/j.parkreldis.2013.05.009 PubMedCrossRefGoogle Scholar
  32. Chemelli R, Willie J, Sinton C, Elmquist J, Scammell T, Lee C, Richardson J, Williams S, Xiong Y, Kisanuki Y, Fitch T, Nakazato M, Hammer R, Saper C, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437–451PubMedCrossRefGoogle Scholar
  33. Claassen D, Josephs K, Ahlskog J, Silber M (2010) REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 75:494–499PubMedPubMedCentralCrossRefGoogle Scholar
  34. Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M, Similowski T, Arnulf I (2010) Is obstructive sleep apnea a problem in Parkinson’s disease? Sleep Med 11(3):247–252. doi: 10.1016/j.sleep.2009.05.008 PubMedCrossRefGoogle Scholar
  35. Comella C, Tanner C, Ristanovic R (1993) Polysomnographic sleep measures in Parkinson’s disease patients with treatment-induced hallucinations. Ann Neurol 34:710–714PubMedCrossRefGoogle Scholar
  36. Committee GPsDSS (2002) Factors impacting on quality of life in Parkinson’s disease: results from an international survey. Mov Disord 17(1):60–67CrossRefGoogle Scholar
  37. Compta Y, Santamaria J, Ratti L, Tolosa E, Iranzo A, Munoz E, Valldeoriola F, Casamitjana R, Rios J, Marti MJ (2009) Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson’s disease dementia. Brain 132(Pt 12):3308–3317. doi: 10.1093/brain/awp263 PubMedCrossRefGoogle Scholar
  38. Dahan L, Astier B, Vautrelle N, Urbain N, Kocsis B, Chouvet G (2007) Prominent burst firing of dopaminergic neurons in the ventral tegmental area during paradoxical sleep. Neuropsychopharmacology 32(6):1232–1241. doi: 10.1038/sj.npp.1301251 PubMedCrossRefGoogle Scholar
  39. De Cock V, Vidailhet M, Leu S et al (2007) Restoration of normal motor control in Parkinson’s disease during REM sleep. Brain 130(Pt 2):450–456PubMedCrossRefGoogle Scholar
  40. De Cock V, Debs R, Oudiette D et al (2011) The improvement of movement and speech during rapid eye movement sleep behavior disorder in multiple system atrophy. Brain 134:856–862PubMedCrossRefGoogle Scholar
  41. De Cock V, Bayard S, Jaussent I, Charif M, Grini M, Langenier M, Yu H, Lopez R, Geny C, Carlander B, Dauvilliers Y (2014) Daytime sleepiness in Parkinson’s disease: a reappraisal. PloS ONE 9(9):e107278. doi: 10.1371/journal.pone.0107278
  42. De Lecea L, Kilduff T, Peyron C et al (1998) The hypocretins: hypothalalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322–327PubMedPubMedCentralCrossRefGoogle Scholar
  43. Detari L, Rasmussin D, Semba K et al (1999) The role of the basal forebrain neurons in tonic and phasic activation of the cerebral cortex. Prog Neurobiol 58:249PubMedCrossRefGoogle Scholar
  44. Diederich N, Vaillant M, Leischen M et al (2005) Sleep apnea syndrome in Parkinson’s disease. A case-control study in 49 patients. Mov Disord 20:1413–1418PubMedCrossRefGoogle Scholar
  45. Diederich NJ, Rufra O, Pieri V, Hipp G, Vaillant M (2013) Lack of polysomnographic Non-REM sleep changes in early Parkinson’s disease. Mov Disord 28(10):1443–1446. doi: 10.1002/mds.25520 PubMedCrossRefGoogle Scholar
  46. Dowling D, Mastick E, Colling J et al (2005) Melatonin for sleep disturbances in Parkinson’s disease. Sleep Med 6(5):459–466PubMedCrossRefGoogle Scholar
  47. Dragan EM, Chen Z, Ondo WG (2015) Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson’s disease: a pilot study. Int J Neurosci 125(7):526–530. doi: 10.3109/00207454.2014.987771 PubMedCrossRefGoogle Scholar
  48. Earley C, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee P, Allen R (2014) Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis–Ekbom Disease). Sleep Med 15:1288–1301PubMedCrossRefGoogle Scholar
  49. Ebrahim I, Sharief M, de Lacy S et al (2003) Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia. J Neurol Neurosurg Psych 74:127–130CrossRefGoogle Scholar
  50. Ekbom K, Ulfberg J (2009) Restless legs syndrome. J Int Med 266(5):419–431CrossRefGoogle Scholar
  51. Espana R, Scammell T (2011) Sleep neurobiology from a clinical perspective. Sleep 34:845–858PubMedPubMedCentralCrossRefGoogle Scholar
  52. Espãna R, Scammell T (2004) Sleep neurobiology for the clinician. Sleep 27:811–820Google Scholar
  53. Espãna R, Scammell T (2011) Sleep neurobiology from a clinical perspective. Sleep 34:845–858PubMedPubMedCentralCrossRefGoogle Scholar
  54. Espãna R, Baldo B, Kelley A et al (2001) Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 106:699–715PubMedCrossRefGoogle Scholar
  55. Fantini M, Gagnon J, Filipini D, Montplaisir J (2003) The effects of pramipexole in REM sleep behavior disorder. Neurology 61:1418–1420PubMedCrossRefGoogle Scholar
  56. Ferreira J, Galitzky M, Montastruc J, Rascol O (2000) Sleep attacks and Parkinson’s disease treatment. Lancet 355:1333–1334PubMedCrossRefGoogle Scholar
  57. Ferreira T, Prabhakar S, Kharbanda PS (2014) Sleep disturbances in drug naive Parkinson’s disease (PD) patients and effect of levodopa on sleep. Ann Indian Acad Neurol 17(4):416–419. doi: 10.4103/0972-2327.144016 PubMedPubMedCentralCrossRefGoogle Scholar
  58. Findley L, Aujila M, Bain P et al (2003) Direct economic impact of Parkinson’s disease: a research survey in the United Kingdom. Mov Disord 17(6):1139–1145CrossRefGoogle Scholar
  59. Friedman J (2002) Presumed rapid eye movement disorder in Machado-Joseph disease (spinocerebellar ataxia type 3). Mov Disord 17(6):1350–1353PubMedCrossRefGoogle Scholar
  60. Friedman J, Chou K (2004) Sleep and fatigue in Parkinson’s disease. Parkinsonism Relat Disord 10(Suppl 1):S27–S35PubMedCrossRefGoogle Scholar
  61. Fronczek R, Overeem S, Lee S, Hegeman M, Van Pelt J, Van Duinen S, Lammers G, Swaab D (2008) Hypocretin (orexin) loss and sleep disturbances in Parkinson’s disease. Brain 131:e88. doi: 10.1093/brain/awm222
  62. Frucht S, Rogers J, Greene P et al (1999) Falling asleep at the wheel: Motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology 52:1908–1910Google Scholar
  63. Gagnon J, Bedard M, Fantini M et al (2002) REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology 59:585–589PubMedCrossRefGoogle Scholar
  64. Gagnon J, Postuma R, Montplaisir J (2006) Update on the pharmacology of REM sleep behavior disorder. Neurology 67:742–747PubMedCrossRefGoogle Scholar
  65. Gjerstad MD, Wentzel-Larsen T, Aarsland D, Larsen JP (2007) Insomnia in Parkinson’s disease: frequency and progression over time. J Neurol Neurosurg Psychiatry 78(5):476–479. doi: 10.1136/jnnp.2006.100370 PubMedCrossRefGoogle Scholar
  66. Gjerstad M, Tysnes O, Larsen J (2011) Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology 77:1941–1946PubMedCrossRefGoogle Scholar
  67. Gong H, McGinty D, Guzman-Marin R et al (2004) Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation. J Physiol 556:935–946PubMedPubMedCentralCrossRefGoogle Scholar
  68. Grinberg L, Rueb U, Di Lorenzo AT, Heinsen H (2010) Brainstem pathology and non-motor symptoms in PD. J Neurol Sci 289:81–88PubMedCrossRefGoogle Scholar
  69. Hagell P, Nordling S, Reimer J et al (2002) Resource use and costs in a Swedish cohort of patients with Parkinson’s disease. Mov Disord 17(6):1213–1220PubMedCrossRefGoogle Scholar
  70. Hansen IH, Marcussen M, Christensen JA, Jennum P, Sorensen HB (2013) Detection of a sleep disorder predicting Parkinson’s disease. Conf Proc IEEE Eng Med Biol Soc 2013:5793–5796. doi: 10.1109/EMBC.2013.6610868 PubMedGoogle Scholar
  71. Hassani O, Henny P, Lee M et al (2010) GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep. Eur J Neurosci 32(3):448–457PubMedPubMedCentralCrossRefGoogle Scholar
  72. Hauri P (1982) The sleep disorders. Current concepts. Upjohn Company, KalamazooGoogle Scholar
  73. Hauser R, Gauaer L, Anderson W, Zesiewicz T (2000) Pramipexole-induced somnolence and episodes of daytime sleep. Mov Disord 15:658–663PubMedCrossRefGoogle Scholar
  74. Hendricks J, Morrison A, Mann G (1982) Different behaviors during paradoxical sleep without atonia depend on pontine lesion site. Brain Res 239(1):81–105PubMedCrossRefGoogle Scholar
  75. Hobson J, McCarley R, Wyzinski P (1975) Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. Science 189:55–58PubMedCrossRefGoogle Scholar
  76. Hobson D, Lang A, Martin W et al (2002) Excessive daytime sleepiness and sudden-onset sleep in Parkinson’s disease. JAMA 287(4):455–463PubMedCrossRefGoogle Scholar
  77. Hogl B, Saletu M, Brandauer E, Glatzl S, Frauscher B, Seppi K, Ulmer H, Wenning G, Poewe W (2002) Modafinil for the treatment of daytime sleepiness in Parkinson’s disease: a double-blind, randomized, crossover, placebo-controlled polygraphic trial. Sleep 25(8):905–909PubMedGoogle Scholar
  78. Hogl B, Seppi K, Brandauer E, Glatzl S, Frauscher B, Niedermuller U, Wenning G, Poewe W (2003) Increased daytime sleepiness in Parkinson’s disease: a questionnaire survey. Mov Disord 18(3):319–323. doi: 10.1002/mds.10365 PubMedCrossRefGoogle Scholar
  79. Imbesi M, Yildiz S, Dirim Arslan A, Sharma R, Manev H, Uz T (2009) Dopamine receptor-mediated regulation of neuronal “clock” gene expression. Neuroscience 158(2):537–544. doi: 10.1016/j.neuroscience.2008.10.044 PubMedCrossRefGoogle Scholar
  80. Iranzo A, Lomena F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, Molinuevo JL, Serradell M, Duch J, Pavia J, Gallego J, Seppi K, Hogl B, Tolosa E, Poewe W, Santamaria J (2010) Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurol 9(11):1070–1077. doi: 10.1016/s1474-4422(10)70216-7 PubMedCrossRefGoogle Scholar
  81. Iwanami M, Miyamoto T, Miyamoto M, Hirata K, Takada E (2010) Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep Med 11(4):361–365. doi: 10.1016/j.sleep.2009.12.006 PubMedCrossRefGoogle Scholar
  82. Joy SP, Sinha S, Pal PK, Panda S, Philip M, Taly AB (2014) Alterations in Polysomnographic (PSG) profile in drug-naïve Parkinson’s disease. Ann Indian Acad Neurol 17(3):287–291. doi: 10.4103/0972-2327.138501 PubMedPubMedCentralCrossRefGoogle Scholar
  83. Kalaitzakis ME, Gentleman SM, Pearce RK (2013) Disturbed sleep in Parkinson’s disease: anatomical and pathological correlates. Neuropathol Appl Neurobiol 39(6):644–653. doi: 10.1111/nan.12024 PubMedCrossRefGoogle Scholar
  84. Karlsen K, Tandberg E, Arsland D, Larsen J (2000) Health related quality of life in Parkinson’s disease: a prospective longitudinal study. J Neurol Neurosurg Psychiatry 69:584–589PubMedPubMedCentralCrossRefGoogle Scholar
  85. Kaynak D, Kiziltan G, Kaynak H et al (2005) Sleep and sleepiness in patients with Parkinson’s disease before and after dopaminergic treatment. Eur J Neurol 12(3):199–207PubMedCrossRefGoogle Scholar
  86. Kerenyi L, Ricaurte G, Schretlen D et al (2003) Positron emission tomography of striatal serotonin transporters in Parkinson’s disease. Arch Neuro 60:1223–1229CrossRefGoogle Scholar
  87. Kilduff T, Peyron C (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci 23:359–365PubMedCrossRefGoogle Scholar
  88. Kish S (2003) Biochemistry of Parkinson’s disease: is a brain serotonergic deficiency a characteristic of idiopathic Parkinson’s disease? Adv Neurol 60:1223–1229Google Scholar
  89. Kish S, Tong J, Hornykiewicz O et al (2008) Preferential loss of serotonin markers in caudate versus putamen in Parkinson’s disease. Brain 131(Pt 1):120–131PubMedGoogle Scholar
  90. Kiyashchenko L, Mileykovskiy B, Lai Y, Siegel J (2001) Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area. J Neurophysiol 85:2008–2016PubMedGoogle Scholar
  91. Knie B, Mitra M, Logishetty K, Chaudhuri K (2011) Excessive daytime sleepiness in patients with Parkinson’s disease. CNS Drugs 25(3):203–212PubMedCrossRefGoogle Scholar
  92. Koella W (1969) Serotonin and sleep. Exp Med Surg 27:157–168PubMedGoogle Scholar
  93. Konadhode R, Pelluru D, Shiromani J (2015) Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep. Front in Systems NeuroSci 8:244. doi: 10.3389/fnsys.2014.00244
  94. Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci 23(1):7–11PubMedGoogle Scholar
  95. Korotkova TM, Brown RE, Sergeeva OA, Ponomarenko AA, Haas HL (2006) Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat. Eur J Neurosci 23(10):2677–2685. doi: 10.1111/j.1460-9568.2006.04792.x PubMedCrossRefGoogle Scholar
  96. Kumar S, Bhatia M, Behari M (2003) Excessive daytime sleepiness in Parkinson’s disease as assessed by Epworth Sleepiness Scale (ESS). Sleep Med 4(4):339–342PubMedCrossRefGoogle Scholar
  97. Lees A, Blackburn N, Campbell V (1988) The nighttime problems of Parkinson’s disease. Clin Neuropharm 6:512–519CrossRefGoogle Scholar
  98. Lu J, Jhou TC, Saper CB (2006a) Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J Neurosci 26(1):193–202. doi: 10.1523/jneurosci.2244-05.2006 PubMedCrossRefGoogle Scholar
  99. Lu J, Sherman D, Devor M, Saper CB (2006b) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589–594. doi: 10.1038/nature04767 PubMedCrossRefGoogle Scholar
  100. Mancia G (1993) Autonomic modulation of the cardiovascular system during sleep. N Engl J Med 328(5):347–349. doi: 10.1056/NEJM199302043280511 PubMedCrossRefGoogle Scholar
  101. Manni R, Pacchetti C, Terzaghi M et al (2002) Hallucinations and sleep-wake cycle in PD: a 24-hour continuous polysomnographic study. Neurology 59:1979–1981PubMedCrossRefGoogle Scholar
  102. Manni R, Ratti PL, Terzaghi M (2011) Secondary “incidental” REM sleep behavior disorder: do we ever think of it? Sleep Med 12(Suppl 2):S50–S53. doi: 10.1016/j.sleep.2011.10.011 PubMedCrossRefGoogle Scholar
  103. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435(1):6–25PubMedCrossRefGoogle Scholar
  104. Maria B, Sophia S, Michalis M et al (2003) Sleep breathing disorders in patients with idiopathic Parkinson’s disease. Resp Med 97:1151–1157CrossRefGoogle Scholar
  105. Martinez-Martin P, Schapira A, Stocchi F et al (2007) Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 22(11):1623–1629PubMedCrossRefGoogle Scholar
  106. Methippara M, Alam N, Szymusiak R et al (2000) Effects of lateral preoptic area application of orexin-A on sleep-wakefulness. NeuroReport 11:3423–3426PubMedCrossRefGoogle Scholar
  107. Micieli G, Tosi P, Marcheselli S, Cavallini A (2003) Autonomic dysfunction in Parkinson’s disease. Neurol Sci 24:S32–S34PubMedCrossRefGoogle Scholar
  108. Miller JD, Farber J, Gatz P, Roffwarg H, German DC (1983) Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and walking in the rat. Brain Res 273(1):133–141PubMedCrossRefGoogle Scholar
  109. Miyamoto T, Miyamoto M, Iwanami M, Hirata K (2011) Follow-up study of cardiac (1)(2)(3)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Eur J Neurol 18(10):1275–1278. doi: 10.1111/j.1468-1331.2011.03392.x PubMedCrossRefGoogle Scholar
  110. Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, Shulman LM, Gronseth G, Weiner WJ (2006) Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 66(7):996–1002. doi: 10.1212/01.wnl.0000215428.46057.3d PubMedCrossRefGoogle Scholar
  111. Monderer R, Thorpy M (2009) Sleep disorders and daytime sleepiness in Parkinson’s disease. Curr Neurol Neurosci Rep 9(2):173–180PubMedCrossRefGoogle Scholar
  112. Monti J (2013) The neurotransmitters of sleep and wake, a physiological reviews series. Sleep Med Rev 17:313–315PubMedCrossRefGoogle Scholar
  113. Monti JM, Monti D (2007) The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev 11(2):113–133. doi: 10.1016/j.smrv.2006.08.003 PubMedCrossRefGoogle Scholar
  114. Moore RY, Bloom FE (1978) Central catecholamine neuron systems: anatomy and physiology of the dopamine systems. Ann Rev Neurosci 1:129–169. doi: 10.1146/annurev.ne.01.030178.001021 PubMedCrossRefGoogle Scholar
  115. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D’Agostino RB, Newman AB, Lebowitz MD, Pickering TG (2000) Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep heart health study. JAMA 283(14):1829–1836PubMedCrossRefGoogle Scholar
  116. Niwa F, Kuriyama N, Nakagawa M, Imanishi J (2011) Circadian rhythm of rest activity and autonomic nervous system activity at different stages in Parkinson’s disease. Auton Neurosci: Basic Clin 165(2):195–200. doi: 10.1016/j.autneu.2011.07.010 CrossRefGoogle Scholar
  117. Ohayon M, Roth T (2002) Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res 53:547–554PubMedCrossRefGoogle Scholar
  118. Ondo WG (2014) Sleep/wake problems in Parkinson’s disease: pathophysiology and clinicopathologic correlations. J Neural Transm (Vienna, Austria: 1996) 121(Suppl 1):S3–S13. doi: 10.1007/s00702-014-1239-6
  119. Ondo W, Dat Vuong K, Khan H et al (2001) Daytime sleepiness and other sleep disorders in Parkinson’s disease. Neurology 57:1392–1396PubMedCrossRefGoogle Scholar
  120. Ondo W, Fayle R, Atassi F et al (2005) Modafinil for daytime somnolencein Parkinson’s disease: double blind, placebo controlled parallel trial. J Neurol Neurosurg Psychiatry 76:1636–1639Google Scholar
  121. Ondo W, Perkins T, Swick T et al (2008) Sodium oxybate for excessive daytime sleepiness in Parkinson’s disease: an open-label polysomnographic study. Arch Neuro 65(10):1337–1340CrossRefGoogle Scholar
  122. Overeem S, van Hilten JJ, Ripley B, Mignot E, Nishino S, Lammers GJ (2002) Normal hypocretin-1 levels in Parkinson’s disease patients with excessive daytime sleepiness. Neurology 58(3):498–499PubMedCrossRefGoogle Scholar
  123. Pacchetti C, Manni R, Zangaglia R et al (2005) Relationship between hallucinations, delusions, and rapid eye movement sleep behavior disorder in Parkinson’s disease. Mov Disord 20:1439–1448PubMedCrossRefGoogle Scholar
  124. Pace-Schott E, Hobson J (2002) The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 3:591–605PubMedCrossRefGoogle Scholar
  125. Parkinson J (1817) An essay on the shaking palsy. An essay on the shaking palsey. Sherwood, Neely and Jones, LondonGoogle Scholar
  126. Pelletier G, Lorrain D, Montplaisir J (1992) Sensory and motor components of the restless legs syndrome. Neurology 42:1663–1666PubMedCrossRefGoogle Scholar
  127. Peppe A, Pierantozzi M, Baiamonte V, Moschella V, Caltagirone C, Stanzione P, Stefani A (2012) Deep brain stimulation of pedunculopontine tegmental nucleus: role in sleep modulation in advanced Parkinson disease patients: one-year follow-up. Sleep 35(12):1637–1642. doi: 10.5665/sleep.2234 PubMedPubMedCentralGoogle Scholar
  128. Plazzi G, Corsini R, Provini F et al (1997) REM sleep behavior disorder in multiple system atrophy. Neurology 48:1094–1097PubMedCrossRefGoogle Scholar
  129. Poceta J (2011) Zolpidem ingestion, automatisms, sleep driving: a clinical and legal case series. J Clin Slp Med 7(6):632–638Google Scholar
  130. Porter B, Macfarlane R, Walker R (2008) The frequency and nature of sleep disorders in a community-based population of patients with Parkinson’s disease. Eur J Neurol 15(1):50–54. doi: 10.1111/j.1468-1331.2007.01998.x PubMedGoogle Scholar
  131. Poryazova R, Benninger D, Waldvogel D, Bassetti C (2010) Excessive daytime sleepiness in Parkinson’s disease: characteristics and determinants. Eur Neuro 63:129–135CrossRefGoogle Scholar
  132. Postuma R, Lang A, Massicotte-Marquez J et al (2006) Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology 66:845–851PubMedCrossRefGoogle Scholar
  133. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J (2009) Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 72(15):1296–1300. doi: 10.1212/01.wnl.0000340980.19702.6e PubMedPubMedCentralCrossRefGoogle Scholar
  134. Postuma RB, Lang AE, Munhoz RP, Charland K, Pelletier A, Moscovich M, Filla L, Zanatta D, Rios Romenets S, Altman R, Chuang R, Shah B (2012) Caffeine for treatment of Parkinson disease: a randomized controlled trial. Neurology 79(7):651–658. doi: 10.1212/WNL.0b013e318263570d PubMedPubMedCentralCrossRefGoogle Scholar
  135. Pressley J, Louis E, Tang M et al (2003) The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism. Neurology 60:87–93PubMedCrossRefGoogle Scholar
  136. Razmy A, Lang A, Shapiro C (2004) Predictors of imp[aired daytime sleep and wakefulness in patients with Parkinson disease treated with older (ergot) vs newer (nonergot) dopamine agonists. Arch Neuro 61(1):97–102CrossRefGoogle Scholar
  137. Ringman J, Simmons J (2000) Treatment of REM sleep behavior disorder with donepezil: a report of three cases. Neurology 55:870–871PubMedCrossRefGoogle Scholar
  138. Roth T, Rye DB, Borchert LD, Bartlett C, Bliwise DL, Cantor C, Gorell JM, Hubble JP, Musch B, Olanow CW, Pollak C, Stern MB, Watts RL (2003) Assessment of sleepiness and unintended sleep in Parkinson’s disease patients taking dopamine agonists. Sleep Med 4(4):275–280PubMedCrossRefGoogle Scholar
  139. Ruoff C, Einen M, Hekmat A, Leary E, Nevsimalova S, Plazzi G, Mignot E (2015) Repeatability of the MSLT in Patients with known CSF hypocretin levels. Sleep 38:A271Google Scholar
  140. Ryan M, Slevin J, Wells A (2000) Non-ergot dopamine agonist-induced sleep attacks. Pharmacotherapy 20(6):724–726PubMedCrossRefGoogle Scholar
  141. Sakai K, Sastre JP, Salvert D, Touret M, Tohyama M, Jouvet M (1979) Tegmentoreticular projections with special reference to the muscular atonia during paradoxical sleep in the cat: an HRP study. Brain Res 176(2):233–254PubMedCrossRefGoogle Scholar
  142. Sakurai T, Amemiya A, Ishii M et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573–585PubMedCrossRefGoogle Scholar
  143. Saper C, Chou T, Scammell T (2001) The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24:726–731PubMedCrossRefGoogle Scholar
  144. Schapira A (2000) Sleep attacks (sleep episodes) with pergolide. Lancet 355:1332–1333PubMedCrossRefGoogle Scholar
  145. Schenck C, Bundlie S, Mahowald M (1996a) Delayed emergence of a parkinsonian disorder in 38 % of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 46:386–393CrossRefGoogle Scholar
  146. Schenck C, Garcia-Rill E, Skinner R et al (1996b) A case of REM sleep behavior disorder with autopsy-confirmed Alzheimer’s disease: postmortem brain stem histochemical analysis. Biol Psych 40(5):422–425CrossRefGoogle Scholar
  147. Schenck CH, Boeve BF, Mahowald MW (2013) Delayed emergence of a parkinsonian disorder or dementia in 81 % of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 14(8):744–748. doi: 10.1016/j.sleep.2012.10.009 PubMedCrossRefGoogle Scholar
  148. Schiermeier S, Schafer D, Schafer T et al (2001) Breathing and locomotion in patients with Parkinson’s disease. Eur J Physiol 443:67–71CrossRefGoogle Scholar
  149. Schonrock B, Busselberg D, Haas H (1991) Properties of tuberomammillary histamine neurons and their response to galanin. Agents Action 33:135–137CrossRefGoogle Scholar
  150. Schrag A, Jahanshahi M, Quinn N (2000) What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry 69(3):308–312Google Scholar
  151. Sforza E, Kreiger J, Petiau C (1997) REM sleep behavior disorder: clinical and physiopathological findings. Sleep Med Rev 1(1):57–69PubMedCrossRefGoogle Scholar
  152. Sherin J, Shiromani P, McCarley R et al (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216–219PubMedCrossRefGoogle Scholar
  153. Sheu JJ, Lee HC, Lin HC, Kao LT, Chung SD (2015) A 5-year follow-up study on the relationship between obstructive sleep apnea and parkinson disease. J Clin Sleep Med: JCSM: official publication of the American Academy of Sleep Medicine 11:1403–1408Google Scholar
  154. Shin HY, Joo EY, Kim ST, Dhong HJ, Cho JW (2013) Comparison study of olfactory function and substantia nigra hyperechogenicity in idiopathic REM sleep behavior disorder, Parkinson’s disease and normal control. Neurol Sci 34(6):935–940. doi: 10.1007/s10072-012-1164-0 PubMedCrossRefGoogle Scholar
  155. Shulman L, Taback R, Bean J, Weiner W (2001) Comorbidity of the nonmotor symptoms of Parkinson’s disease. Mov Disord 16(3):5078–5510CrossRefGoogle Scholar
  156. Shulman L, Taback R, Rabinstein A et al (2002) Non-recognition of depression and other non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord 8(3):193–197PubMedCrossRefGoogle Scholar
  157. Spillantini M, Crowther R, Jakes R et al (1998) Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson’s disease and dementia with Lewy bodies. Neurosci Lett 251(3):205–208PubMedCrossRefGoogle Scholar
  158. Steriade M (1996) Arousal: revisting the reticular activating system. Science 272:225–226PubMedCrossRefGoogle Scholar
  159. Steriade M, Datta S, Pare D et al (1990) Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 10:2541–2559PubMedGoogle Scholar
  160. Stevens S, Comella C, Stepanski E (2004) Daytime sleepiness and alertness in patients with Parkinson’s disease. Sleep 27(5):967–972PubMedGoogle Scholar
  161. Suntsova N, Szymusiak R, Alam N, Guzman-Marin R, McGinty D (2002) Sleep-waking discharge patterns of median preoptic nucleus neurons in rats. J Physiol 543:665–677)Google Scholar
  162. Swick T (2012) The neurology of sleep 2012. In: Lee-Chiong T (ed) Biology of sleep, vol 7. Sleep Medicine Clinics. W.B. Saunders, Philadelphia, pp 399–415Google Scholar
  163. Szewczyk-Krolikowski K, Tomlinson P, Nithi K, Wade-Martins R, Talbot K, Ben-Shlomo Y, Hu MT (2014) The influence of age and gender on motor and non-motor features of early Parkinson’s disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort. Parkinsonism Relat Disord 20(1):99–105. doi: 10.1016/j.parkreldis.2013.09.025 PubMedCrossRefGoogle Scholar
  164. Szymusiak R, Alam N, Steininger T, McGinty D (1998) Sleep-waking discharge  patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res 803:178–188PubMedCrossRefGoogle Scholar
  165. Takahashi K, Lin J, Saki K (2009) Characterization and mapping of sleep-waking specific neurons in the basal forebrain and preoptic hypothalamus in mice. Neuroscience 161:269–292PubMedCrossRefGoogle Scholar
  166. Takeuchi N, Uchimura N, Hashizume Y et al (2001) Melatonin therapy for REM sleep behavior disorder. Psychiat Clin Neurosci 55:267–269CrossRefGoogle Scholar
  167. Tan A, Salgado M, Fahn S et al (1996) Rapid eye movement sleep behavior disorder preceeding Parkinson’s disease with therapeutic response to levodopa. Mov Disord 11:214–216PubMedCrossRefGoogle Scholar
  168. Tandberg E, Larsen J, Karlsen K (1998) A community-based study of sleep disorders in patients with Parkinson’s disease. Mov Disord 13(6):895–899PubMedCrossRefGoogle Scholar
  169. Tandberg E, Larsen J, Karlsen K (1999) Excessive daytime sleepiness and sleep benefit in Parkinson’s disease: a community-based study. Mov Disord 14(6):922–927PubMedCrossRefGoogle Scholar
  170. Thannickal T, Lai Y, Siegel J (2007) Hypocretin (orexin) cell loss in Parkinson’s disease. Brain 130:1586–1595PubMedCrossRefGoogle Scholar
  171. Tholfsen L, Larsen J, Schulz J, Tysnes O, Gjerstad M (2015) Development of excessive daytime sleepiness in early Parkinson disease. Neurology 85(2):162–168PubMedCrossRefGoogle Scholar
  172. Thorpy M (2004) Sleep disorders in Parkinson’s disease. Clin Cornerstone 6(Suppl 1A):S7–S15PubMedCrossRefGoogle Scholar
  173. Tork I (1990) Anatomy of the serotonergic system. Ann NY Acad Sci 600:9–34PubMedCrossRefGoogle Scholar
  174. Torterolo P, Lagos P, Monti J (2011) Melanin-concentrating hormone: a new sleep factor? Front Neurol 2:1–12. doi: 10.3389/fneur.2011.00014
  175. Trotti LM, Bliwise DL (2010) No increased risk of obstructive sleep apnea in Parkinson’s disease. Mov Disord 25(13):2246–2249. doi: 10.1002/mds.23231 PubMedPubMedCentralCrossRefGoogle Scholar
  176. Trotti L, Staab B, Rye D (2013) Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. J Clin Slp Med 9(8):789–795. doi: 10.5664/jcsm.2922 Google Scholar
  177. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Leger L, Boissard R, Salin P, Peyron C, Luppi PH (2003) A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 4:19. doi: 10.1186/1471-2202-4-19 PubMedPubMedCentralCrossRefGoogle Scholar
  178. Videnovic A, Golombek D (2013) Circadian and sleep disorders in Parkinson’s disease. Exp Neurol 243:45–56. doi: 10.1016/j.expneurol.2012.08.018 PubMedCrossRefGoogle Scholar
  179. Videnovic A, Noble C, Reid K, Peng J, Turek F, Marconi A, Rademaker A, Simuni T, Zadikoff C, Zee P (2014) Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson’s disease. JAMA Neuro 71(4):463–469. doi: 10.1001/jamaneurol.2013.6239 CrossRefGoogle Scholar
  180. Wienecke M, Werth E, Poryazova R, Baumann-Vogel H, Bassetti CL, Weller M, Waldvogel D, Storch A, Baumann CR (2012) Progressive dopamine and hypocretin deficiencies in Parkinson’s disease: is there an impact on sleep and wakefulness? J Sleep Res 21(6):710–717. doi: 10.1111/j.1365-2869.2012.01027.x
  181. Winkelman J, James L (2004) Serotonergic antidepressants are associated with REM sleep without atonia. Sleep 27(2):317–321PubMedGoogle Scholar
  182. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM (2001) Dopaminergic role in stimulant-induced wakefulness. J Neurosci 21(5):1787–1794PubMedGoogle Scholar
  183. Witjas T, Kaphan E, Azulay J et al (2002) Nonmotor fluctuations in Parkinson’s disease: frequent and disabling. Neurology 59:408–413PubMedCrossRefGoogle Scholar
  184. Xi MC, Morales FR, Chase MH (2004) Interactions between GABAergic and cholinergic processes in the nucleus pontis oralis: neuronal mechanisms controlling active (rapid eye movement) sleep and wakefulness. J Neurosci 24(47):10670–10678. doi: 10.1523/jneurosci.1987-04.2004 PubMedCrossRefGoogle Scholar
  185. Yaltho T, Ondo W (2010) The use of gabapentin encarbil in the treatment of restless legs syndrome. Therap Adv Neurologic Disord 3(5):269–275CrossRefGoogle Scholar
  186. Yang Q, Hatton G (1997) Electrophysiology of excitatory and inhibitory afferents to rat histaminergic tuberomammillary nucleus neurons from hypothalamic and forebrain sites. Brain Res 773:162–172PubMedCrossRefGoogle Scholar
  187. Yujnovsky I, Hirayama J, Doi M, Borrelli E, Sassone-Corsi P (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci USA 103(16):6386–6391. doi: 10.1073/pnas.0510691103

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.University of Texas School of Medicine-HoustonHoustonUSA
  2. 2.Apnix Sleep Disorders CentersHoustonUSA
  3. 3.The Sleep Center at North Cypress Medical CenterCypressUSA
  4. 4.Methodist Neurological InstituteHoustonUSA

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