Skip to main content
SpringerLink
Log in

The Effects of Dopamine Receptor Agonists on the Sleep-Wake Cycle

  • Chapter
  • First Online:
Dopamine and Sleep

Abstract

Dopamine (DA), a neurotransmitter that regulates the sleep-wake cycle, has been involved as a wake-promoting molecule. Moreover, the diversity of neurobiological functions controlled by DA, including the sleep-wake cycle, are mediated by the DA family, which comprises D1, D2, D3, D4 and D5 receptors. From the pharmacological point of view, compounds that bind and activate DA receptors are significant means for the study of mechanism of action of DA controlling biological phenomena such as sleep. Here, we highlight the current knowledge regarding the role of DA receptor agonist in sleep modulation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arnsten AF, Wang M, Paspalas CD (2015) Dopamine’s actions in primate prefrontal cortex: challenges for treating cognitive disorders. Pharmacol Rev 67:681–696

    Article  PubMed  PubMed Central  Google Scholar 

  • Barik S, de Beaurepaire R (2005) Dopamine D3 modulation of locomotor activity and sleep in the nucleus accumbens and in lobules 9 and 10 of the cerebellum in the rat. Prog Neuropsychopharmacol Biol Psychiatry 29:718–726

    Article  CAS  PubMed  Google Scholar 

  • Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut PO, Feyder M, Francardo V, Alcacer C, Ding Y, Brambilla R, Fisone G, Jon Stoessl A, Bourdenx M, Engeln M, Navailles S, De Deurwaerdere P, Ko WK, Simola N, Morelli M, Groc L, Rodriguez MC, Gurevich EV, Quik M, Morari M, Mellone M, Gardoni F, Tronci E, Guehl D, Tison F, Crossman AR, Kang UJ, Steece-Collier K, Fox S, Carta M, Angela Cenci M, Bezard E (2015) Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson’s disease. Prog Neurobiol 132:96–168

    Article  CAS  PubMed  Google Scholar 

  • Beaulieu JM, Espinoza S, Gainetdinov RR (2015) Dopamine receptors—IUPHAR review 13. Br J Pharmacol 172:1–23

    Article  CAS  PubMed  Google Scholar 

  • Berthet A, Bezard E (2009) Dopamine receptors and L-dopa-induced dyskinesia. Parkinsonism Relat Disord 15(Suppl 4):S8–S12

    Article  PubMed  Google Scholar 

  • Bodea GO, Blaess S (2015) Establishing diversity in the dopaminergic system. FEBS Lett 589:3773–3785

    Article  CAS  PubMed  Google Scholar 

  • Boyd KN, Mailman RB (2012) Dopamine receptor signaling and current and future antipsychotic drugs. Handbook of experimental pharmacology. pp 53–86

    Google Scholar 

  • Brust TF, Conley JM, Watts VJ (2015) Galpha(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later. Eur J Pharmacol 763:223–232

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cooper DM (2015) Store-operated Ca(2)(+)-entry and adenylyl cyclase. Cell Calcium 58:368–375

    Article  CAS  PubMed  Google Scholar 

  • Coria-Avila GA, Manzo J, Garcia LI, Carrillo P, Miquel M, Pfaus JG (2014) Neurobiology of social attachments. Neurosci Biobehav Rev 43:173–182

    Article  PubMed  Google Scholar 

  • Dzirasa K, Ribeiro S, Costa R, Santos LM, Lin SC, Grosmark A, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MA (2006) Dopaminergic control of sleep-wake states. J Neurosci: Off J Soc Neurosci 26:10577–10589

    Article  CAS  Google Scholar 

  • Ferreira JJ, Galitzky M, Thalamas C, Tiberge M, Montastruc JL, Sampaio C, Rascol O (2002) Effect of ropinirole on sleep onset: a randomized, placebo-controlled study in healthy volunteers. Neurology 58:460–462

    Article  CAS  PubMed  Google Scholar 

  • Fiorentini C, Savoia P, Savoldi D, Missale C (2013) Receptor heteromers in Parkinson’s disease and L-DOPA-induced dyskinesia. CNS Neurol Disord: Drug Targets 12:1101–1113

    CAS  Google Scholar 

  • Gouraud A, Millaret A, Descotes J, Vial T, French Association of Regional Pharmacovigilance Centres (2011) Piribedil-induced sleep attacks in patients without Parkinson disease: a case series. Clin Neuropharmacol 34:104–107

    Google Scholar 

  • Hyacinthe C, Barraud Q, Tison F, Bezard E, Ghorayeb I (2014) D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism. Neurobiol Dis 63:20–24

    Article  CAS  PubMed  Google Scholar 

  • Inta D, Lima-Ojeda JM, Gass P, Fusar-Poli P (2012) Postnatal neurogenesis and dopamine alterations in early psychosis. Recent Pat CNS Drug Discovery 7:236–242

    Article  CAS  PubMed  Google Scholar 

  • Isaac SO, Berridge CW (2003) Wake-promoting actions of dopamine D1 and D2 receptor stimulation. J Pharmacol Exp Ther 307:386–394

    Article  CAS  PubMed  Google Scholar 

  • Jefferson F, Ehlen JC, Williams NS, Montemarano JJ, Paul KN (2014) A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology 155:4411–4421

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jones BE (2005) From waking to sleeping: neuronal and chemical substrates. Trends Pharmacol Sci 26:578–586

    Article  CAS  PubMed  Google Scholar 

  • Lagos P, Scorza C, Monti JM, Jantos H, Reyes-Parada M, Silveira R, Ponzoni A (1998) Effects of the D3 preferring dopamine agonist pramipexole on sleep and waking, locomotor activity and striatal dopamine release in rats. Eur Neuropsychopharmacol: J Eur Coll Neuropsychopharmacol 8:113–120

    Article  CAS  Google Scholar 

  • Le Foll B, Collo G, Rabiner EA, Boileau I, Merlo Pich E, Sokoloff P (2014) Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings. Prog Brain Res 211:255–275

    Article  PubMed  Google Scholar 

  • Liguori C, Placidi F, Stefani A, Mercuri NB, Marciani MG, Stanzione P, Pierantozzi M (2015) Rotigotine effect on sleep in a de novo Parkinson’s disease patient affected by periodic limb movement disorder. Parkinsonism Relat Disord 21:1476–1478

    Article  PubMed  Google Scholar 

  • Lima MM, Andersen ML, Reksidler AB, Silva A, Zager A, Zanata SM, Vital MA, Tufik S (2008) Blockage of dopaminergic D(2) receptors produces decrease of REM but not of slow wave sleep in rats after REM sleep deprivation. Behav Brain Res 188:406–411

    Article  CAS  PubMed  Google Scholar 

  • Luo F, Li C, Ondo WG, Xu P, Xie W, Le W (2011) The long-term effects of the dopamine agonist pramipexole in a proposed restless legs syndrome animal model. Sleep Med 12:41–46

    Article  PubMed  Google Scholar 

  • Maloney KJ, Mainville L, Jones BE (2002) c-Fos expression in dopaminergic and GABAergic neurons of the ventral mesencephalic tegmentum after paradoxical sleep deprivation and recovery. Eur J Neurosci 15:774–778

    Article  PubMed  Google Scholar 

  • McGinty DJ, Harper RM (1976) Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 101:569–575

    Article  CAS  PubMed  Google Scholar 

  • McGinty DJ, Szymusiak RS (2005) Principles and practice of sleep medicine. Elsevier Saunders, Philadelphia

    Google Scholar 

  • Micallef J, Rey M, Eusebio A, Audebert C, Rouby F, Jouve E, Tardieu S, Blin O (2009) Antiparkinsonian drug-induced sleepiness: a double-blind placebo-controlled study of L-dopa, bromocriptine and pramipexole in healthy subjects. Br J Clin Pharmacol 67:333–340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mirenowicz J, Schultz W (1996) Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. Nature 379:449–451

    Article  CAS  PubMed  Google Scholar 

  • Monti JM, Fernandez M, Jantos H (1990) Sleep during acute dopamine D1 agonist SKF 38393 or D1 antagonist SCH 23390 administration in rats. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 3:153–162

    CAS  Google Scholar 

  • Monti JM, Jantos H (2008) The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Prog Brain Res 172:625–646

    Article  CAS  PubMed  Google Scholar 

  • Monti JM, Monti D (2007) The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev 11:113–133

    Article  PubMed  Google Scholar 

  • Monti JM, Jantos H, Fernandez M (1989) Effects of the selective dopamine D-2 receptor agonist, quinpirole on sleep and wakefulness in the rat. Eur J Pharmacol 169:61–66

    Article  CAS  PubMed  Google Scholar 

  • Moreira FA, Dalley JW (2015) Dopamine receptor partial agonists and addiction. Eur J Pharmacol 752:112–115

    Article  CAS  PubMed  Google Scholar 

  • Nakazawa S, Nakamichi K, Imai H, Ichihara J (2015) Effect of dopamine D4 receptor agonists on sleep architecture in rats. Prog Neuropsychopharmacol Biol Psychiatry 63:6–13

    Article  CAS  PubMed  Google Scholar 

  • Pagonabarraga J, Pinol G, Cardozo A, Sanz P, Puente V, Otermin P, Legarda I, Delgado T, Serrano C, Balaguer E, Aguirregomozcorta M, Alvarez R, Kulisevsky JJ (2015) Transdermal Rotigotine improves sleep fragmentation in Parkinson’s disease: results of the multicenter, prospective SLEEP-FRAM study. Parkinson’s Dis 2015:131508

    Google Scholar 

  • Pich EM, Collo G (2015) Pharmacological targeting of dopamine D3 receptors: possible clinical applications of selective drugs. Eur Neuropsychopharmacol: J Eur Coll Neuropsychopharmacol 25:1437–1447

    Article  CAS  Google Scholar 

  • Python A, de Saint Hilaire Z, Gaillard JM (1996) Effects of a D2 receptor agonist RO 41-9067 alone and with clonidine on sleep parameters in the rat. Pharmacol Biochem Behav 53:291–296

    Article  CAS  PubMed  Google Scholar 

  • Ramirez AD, Smith SM (2014) Regulation of dopamine signaling in the striatum by phosphodiesterase inhibitors: novel therapeutics to treat neurological and psychiatric disorders. Cent Nerv Syst Agents Med Chem 14:72–82

    Article  CAS  PubMed  Google Scholar 

  • Rangel-Barajas C, Coronel I, Floran B (2015) Dopamine receptors and neurodegeneration. Aging Dis 6:349–368

    Article  PubMed  PubMed Central  Google Scholar 

  • Savica R, Benarroch EE (2014) Dopamine receptor signaling in the forebrain: recent insights and clinical implications. Neurology 83:758–767

    Article  PubMed  Google Scholar 

  • Serafini A, Lorenzut S, Gigli GL, Merlino G, Valente M (2010) The use of rotigotine in the treatment of restless legs syndrome. Ther Adv Neurol Disord 3:241–248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smith Y, Kieval JZ (2000) Anatomy of the dopamine system in the basal ganglia. Trends Neurosci 23:S28–S33

    Article  CAS  PubMed  Google Scholar 

  • Stiasny K, Robbecke J, Schuler P, Oertel WH (2000) Treatment of idiopathic restless legs syndrome (RLS) with the D2-agonist cabergoline–an open clinical trial. Sleep 23:349–354

    CAS  PubMed  Google Scholar 

  • Trampus M, Ferri N, Adami M, Ongini E (1993) The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat. Eur J Pharmacol 235:83–87

    Article  CAS  PubMed  Google Scholar 

  • Trampus M, Ferri N, Monopoli A, Ongini E (1991) The dopamine D1 receptor is involved in the regulation of REM sleep in the rat. Eur J Pharmacol 194:189–194

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Oscar Arias-Carrión is supported by CONACYT-BMBF 2013 (Grant 208132). Eric Murillo-Rodríguez is supported by Escuela de Medicina, Universidad Anáhuac Mayab.

Author information

Authors and Affiliations

  1. Unidad de Trastornos del Movimiento y Sueño (TMS), Hospital General Dr. Manuel Gea González, México D.F., Mexico

    Andrea Herrera-Solís & Oscar Arias-Carrión

  2. Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico

    Andrea Sarro-Ramírez, Mireille Salas-Crisóstomo & Eric Murillo-Rodríguez

  3. Grupo de Investigación en Envejecimiento, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico

    Andrea Sarro-Ramírez, Mireille Salas-Crisóstomo & Eric Murillo-Rodríguez

  4. Grupo de Investigación Desarrollos Tecnológicos para la Salud, División de Ingeniería y Ciencias Exactas, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico

    Eric Murillo-Rodríguez

Authors
  1. Andrea Herrera-Solís
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Oscar Arias-Carrión
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrea Sarro-Ramírez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mireille Salas-Crisóstomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eric Murillo-Rodríguez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric Murillo-Rodríguez .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, School of Medicine, Montevideo, Uruguay

    Jaime M. Monti

  2. Somnogen Canada Inc., Toronto, Ontario, Canada

    S. R. Pandi-Perumal

  3. Department of Neurology, New Jersey Neuroscience Institute, Edison, New Jersey, USA

    S. Chokroverty

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Herrera-Solís, A., Arias-Carrión, O., Sarro-Ramírez, A., Salas-Crisóstomo, M., Murillo-Rodríguez, E. (2016). The Effects of Dopamine Receptor Agonists on the Sleep-Wake Cycle. In: Monti, J., Pandi-Perumal, S., Chokroverty, S. (eds) Dopamine and Sleep. Springer, Cham. https://doi.org/10.1007/978-3-319-46437-4_3

Download citation

Publish with us

Policies and ethics

Search

Navigation