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Dopamine in REM Sleep Regulation

  • Mudasir Ahmad Khanday
  • Raghunandan Kumar Yadav
  • Birendra Nath Mallick
Chapter

Abstract

The dopamine (DA)-ergic neurons are primarily localized in the substantia nigra (SN) and ventral tegmental area (VTA) of the brainstem. These neurons are involved in diverse functions including control of movements, reward, sleep-wakefulness and rapid eye movement sleep (REMS). Loss of these DA-ergic neurons is associated with different behavioral disorders, including Parkinson’s disease, depression, REMS behavior disorder (RBD) and notably in all these disorders sleep including REMS is affected. These neurons receive projections from the locus coeruleus (REM-OFF) and laterodorsal/pedunculopontinetegmentum (REM-ON), neurons, and these modulate REMS. However, how these DA-ergic neurons regulate REMS largely remains unknown. Relevant literatures suggest that the DA-ergic neurons may have an indirect modulatory role, which however needs confirmation.

Keyword

Dopamine Dopamine receptors Parkinson’s disease REMS behavior disorder Substantia nigra Ventral tegmental area 

Abbreviations

DA

Dopamine

DAT

DA uptake transporter

EEG

Electroencephalogram

EMG

Electromyogram

EOG

Electrooculogram

LC

Locus coeruleus

LDT

Latero-dorsal tegementum

NA

Noradrenaline

NREMS

Non-REMS

PD

Parkinson’s disease

PPT

Pedunclo-pontinetegmentum

RBD

REMS behavior disorder

REMS

Rapid eye movement sleep

REMSD

REMS deprivation

SN

Substantia nigra

SNc

SN pars compacta

SNr

SN pars reticulata

VTA

Ventral tegmental area

Notes

Acknowledgments

MAK and RKY received UGC fellowship. Research funding from Indian funding agencies viz. DBT-BUILDER, PURSE II and UPOE-II under Institutional support and individual support under J.C. Bose fellowship and UGC to BNM are acknowledged.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Mudasir Ahmad Khanday
    • 1
  • Raghunandan Kumar Yadav
    • 1
  • Birendra Nath Mallick
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia

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