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GMP-Compliant Perinatal Tissue-Derived Stem Cells

  • Babak ArjmandEmail author
  • Parisa Goodarzi
  • Khadijeh Falahzadeh
  • Hamid Reza Aghayan
  • Fakher Rahim
  • Fereshteh Mohamadi-Jahani
  • Bagher Larijani
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Regenerative medicine as a novel approach uses biological methods and products to regenerate, repair, replace, and enhance the lost function of an organ or tissue. Stem cells have a crucial role in regenerative medicine. Therefore, several sources of stem cells have been used for cell therapy, tissue engineering and regenerative medicine. Recently, perinatal stem cells as a promising cell source have been suggested for regenerative medicine. Their great advantages such as convenient accessibility, low immunogenicity, high proliferation capacity, and minimal ethical limitations have introduced them as a novel source for regenerative medicine. However, good manufacturing practice (GMP) is needed to provide these cells with defined quality, safety, and efficacy for clinical application. Like to other types of stem cells, perinatal stem cells manufacturing in accordance with GMP regulations and standards could provide a valuable source of stem cells for cell therapy and regenerative medicine.

Keywords

Cell therapy Mesenchymal stromal cells Perinatal stem cells Umbilical cord Good manufacturing practice Regenerative medicine 

Notes

Acknowledgements

The authors would like to acknowledge Dr. Bahram Moazami, Maryam moghadari, and Maryam sadat Gousheh for their kind support in procurement of the donated tissues. We also like to thank Dr. Mohamad Vasei, Dr. Nasser Ahmadbeigi, Dr. Yousof Gheisari, Dr. Hossein Adibi, Shokouh Salimi, Hanieh Rostamabadi, and Azam Ranjbar.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Babak Arjmand
    • 1
    • 2
    Email author
  • Parisa Goodarzi
    • 2
  • Khadijeh Falahzadeh
    • 3
  • Hamid Reza Aghayan
    • 3
  • Fakher Rahim
    • 4
  • Fereshteh Mohamadi-Jahani
    • 2
  • Bagher Larijani
    • 1
  1. 1.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  2. 2.Brain and Spinal Cord Injury Research CenterTehran University of Medical SciencesTehranIran
  3. 3.Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Institute of Health Research, Thalassemia and Hemoglobinopathies Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIran

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