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Perinatal Tissue-Derived Stem Cells pp 65–80Cite as

Perinatal Tissue-Derived Endothelial Progenitor Cells

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Endothelial progenitor cells (EPC) have been proposed as a cell population with de novo vessel formation potential for cardiovascular disease treatment, through improving neovascularization in ischemic tissues. Although initially the bone marrow was considered as the main source, EPC have been isolated from other tissues, including perinatal sources: umbilical cord blood and placenta. Perinatal EPC demonstrated similar phenotypic characteristics to other sources; however, they harbor advanced EPC quantity with improved proliferative potential. In vivo experiments also confirmed de novo vessel formation upon perinatal EPC transplantation and enhanced blood perfusion in engraftment areas. Altogether, the fetal EPC have been isolated and characterized from perinatal tissues with improved vascularization potential and at clinically relevant quantities. In this chapter, we will first review vascularization processes in the human placenta and then highlight strategies which have been conducted to harvest EPC from the human term placenta.

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Acknowledgements

This study was supported by the National Health and Medical Research Council (Project Grant 1023368). K.K. was supported by the National Health and Medical Research Council Career Development Fellowship (Grant 1023371).

Conflict of Interest. The authors report no potential conflicts of interest.

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Authors and Affiliations

  1. UQ Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women’s Hospital Building 71/918, Brisbane, QLD, 4029, Australia

    Abbas Shafiee & Kiarash Khosrotehrani M.D., Ph.D., F.A.C.D.

  2. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia

    Abbas Shafiee

  3. UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia

    Kiarash Khosrotehrani M.D., Ph.D., F.A.C.D.

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  1. Abbas Shafiee
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Correspondence to Kiarash Khosrotehrani M.D., Ph.D., F.A.C.D. .

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  1. Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences & Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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Shafiee, A., Khosrotehrani, K. (2016). Perinatal Tissue-Derived Endothelial Progenitor Cells. In: Arjmand, B. (eds) Perinatal Tissue-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46410-7_4

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