Perinatal Tissue-Derived Endothelial Progenitor Cells

  • Abbas Shafiee
  • Kiarash KhosrotehraniEmail author
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Endothelial progenitor cells (EPC) have been proposed as a cell population with de novo vessel formation potential for cardiovascular disease treatment, through improving neovascularization in ischemic tissues. Although initially the bone marrow was considered as the main source, EPC have been isolated from other tissues, including perinatal sources: umbilical cord blood and placenta. Perinatal EPC demonstrated similar phenotypic characteristics to other sources; however, they harbor advanced EPC quantity with improved proliferative potential. In vivo experiments also confirmed de novo vessel formation upon perinatal EPC transplantation and enhanced blood perfusion in engraftment areas. Altogether, the fetal EPC have been isolated and characterized from perinatal tissues with improved vascularization potential and at clinically relevant quantities. In this chapter, we will first review vascularization processes in the human placenta and then highlight strategies which have been conducted to harvest EPC from the human term placenta.


Endothelial Progenitor Cells EPC Perinatal Placenta Vascularization Stem cell 



This study was supported by the National Health and Medical Research Council (Project Grant 1023368). K.K. was supported by the National Health and Medical Research Council Career Development Fellowship (Grant 1023371).

Conflict of Interest. The authors report no potential conflicts of interest.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.UQ Centre for Clinical ResearchThe University of QueenslandBrisbaneAustralia
  2. 2.Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia
  3. 3.UQ Diamantina Institute, Translational Research InstituteThe University of QueenslandBrisbaneAustralia

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