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Umbilical Cord Tissue and Wharton’s Jelly Mesenchymal Stem Cells Properties and Therapeutic Potentials

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Perinatal Tissue-Derived Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Umbilical cord (UC) tissue, which provides the fetus with nutrient-rich, oxygenated blood is one of the most promising sources of stem cells with several advantages. Mesenchymal stem cells (MSCs) isolate from different regions of UC such as Wharton’s jelly (WJ), amnion, perivascular area, arteries, and vein. WJ-derived MSCs have some advantages over other regions of UC. Larger numbers of MSCs could be harvested from WJ with a reduced amount of non-MSC contaminants and they retain their differentiation and proliferation abilities for long periods of time in culture conditions.

In this chapter, we give a brief review about, in vitro and preclinical studies and the potential therapeutic effects of WJ-MSCs for clinic applications through their homing, chemoattraction, survival, multilineage differentiation potential, immunomodulation, antiapoptotic, and anti-inflammatory abilities.

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Acknowledgements

The authors would like to thank AyberkAkat, M.Sc. for his contributions in the writing of the manuscript.

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Authors and Affiliations

  1. Centre for Regenerative Medicine and Stem Cell Manufacturing, LivMedCell, Liv Hospital, Ahmet Adnan Saygun Cd. Canan Sk. No:5, İstanbul, Turkey

    Erdal Karaöz Ph.D & Çiğdem İnci M.Sc.

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  1. Erdal Karaöz Ph.D
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  2. Çiğdem İnci M.Sc.
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Correspondence to Erdal Karaöz Ph.D .

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Editors and Affiliations

  1. Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences & Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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Karaöz, E., İnci, Ç. (2016). Umbilical Cord Tissue and Wharton’s Jelly Mesenchymal Stem Cells Properties and Therapeutic Potentials. In: Arjmand, B. (eds) Perinatal Tissue-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46410-7_3

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