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Cardiac Allograft Vasculopathy

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The Pathology of Cardiac Transplantation

Abstract

Cardiac allograft vasculopathy (CAV) is a complex disease of the vasculature of the grafted heart. It is the major cause of graft loss and mortality 1 year posttransplantation. Imaging techniques are the main tools for detecting and classifying CAV. The disease typically involves the epicardial coronary arteries and spreads into the intramyocardial branches. Pathologic features are heterogeneous and include concentric proliferative intimal lesions and vascular inflammation, which can be associated with conventional atherosclerotic plaques. The involvement of the small arteries and the microcirculation, the microvasculopathy, is responsible for structural and functional changes. Among the multiple risk factors associated with CAV, antibody-mediated rejection is currently recognized as the principle.

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Authors and Affiliations

  1. Cardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular Sciences, Azienda Ospedaliera Padua, Padua, Italy

    Marny Fedrigo

  2. Cardiac Pathology Department, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain

    Jorge Pombo Otero

  3. Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Francesco Tona & Carlo Dal Lin

  4. Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña e Instituto de Investigación Biomédica (INIBIC) A Coruña, A Coruña, Spain

    Marisa Crespo Leiro

  5. Department of Pathology, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France

    Patrick Bruneval

Authors
  1. Marny Fedrigo
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  2. Jorge Pombo Otero
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  3. Francesco Tona
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  4. Carlo Dal Lin
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  5. Marisa Crespo Leiro
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  6. Patrick Bruneval
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Corresponding author

Correspondence to Patrick Bruneval .

Editor information

Editors and Affiliations

  1. Cardiovascular and Cardiac Transplant Pathology Program Department of Pathology, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Ornella Leone

  2. Pathology of Cardiac Transplantation and Regenerative Medicine Unit Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Annalisa Angelini

  3. Department of Pathology, Hôpital Européen Georges Pompidou, Paris, France

    Patrick Bruneval

  4. Heart Failure and Heart Transplant Program, Cardiology Unit, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Luciano Potena

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Fedrigo, M., Pombo Otero, J., Tona, F., Dal Lin, C., Crespo Leiro, M., Bruneval, P. (2016). Cardiac Allograft Vasculopathy. In: Leone, O., Angelini, A., Bruneval, P., Potena, L. (eds) The Pathology of Cardiac Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-46386-5_18

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  • DOI: https://doi.org/10.1007/978-3-319-46386-5_18

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