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Heat Shock Proteins and Phytochemicals: Role in Human Health and Disease

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Book cover Heat Shock Proteins and Plants

Part of the book series: Heat Shock Proteins ((HESP,volume 10))

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Abstract

The use of plants for therapeutic purpose has a long history in many continents. However, the potential of phytochemicals, the bioactive components in the plant, in disease prevention and treatment is recognized and supported only recently by the scientific community. A lot of human diseases and health-related issues are related to the disruption of redox homeostasis by various stressors encountered constantly throughout human life. As a consequence, it leads to accumulation of abnormal proteins, inflammatory response, and oxidative stress, which are common denominators shared by many degenerative disorders. Heat shock proteins are stress proteins known to provide cytoprotection and play important roles in protein folding/unfolding. This chapter briefly describes recent findings in the effects of phytochemicals on oxidative stress-involved ischemia/reperfusion injury, obesity, and liver diseases through regulation of heat shock proteins. These phytochemicals include caffeic acid phenethyl ester from bee glue, synthetic oleanane triterpenoid CDDO-Im, curcumin from Indian spice turmeric, resveratrol from red grapes, naringin found in grapefruit, epigallocatechin-3-gallate from green tea, anthocyanins from pomegranate, and flavonoids.

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Abbreviations

ARE:

antioxidant response element

ASH:

alcoholic steatohepatitis

CA:

caffeic acid

CAPE:

caffeic acid phenethyl ester

CCl4 :

carbon tetrachloride

CDDO:

2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid

CDDO-Im:

1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

DENA:

diethylnitrosamine

EGCG:

Epigallocatechin-3-Gallate

HCC:

hepatocellular carcinoma

HO-1:

heme oxygenase-1

HSF-1:

heat shock factor 1

HSPs:

heat shock proteins

HUVEC:

human umbilical vein endothelial cells

I/R:

ischemia/reperfusion

Keap1:

Kelch-like ECH-associated protein 1

MB:

mallory bodies

NASH:

nonalcoholic steatohepatitis

NF-kB:

nuclear factor kappa B

Nrf2:

nuclear factor, erythroid 2-like 2

PPAR-γ:

peroxisome proliferator-activated receptor gamma

ROS:

reactive oxygen species

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Acknowledgments

Some of the work discussed in this chapter was supported by the grant from the Center for Chronic Disorders of Aging (CCDA) to W. X.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine, Georgia Campus, Suwanee, GA, USA

    Xinyu Wang, Srujana Rayalam & Vishakha Bhave

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  1. Xinyu Wang
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  2. Srujana Rayalam
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  3. Vishakha Bhave
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Correspondence to Xinyu Wang .

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Editors and Affiliations

  1. Department of Neuroscience, University of Dammam, Damman, Saudi Arabia

    Alexzander A. A. Asea

  2. Division of Molecular and Cellular Biology Department of Radiation Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

    Punit Kaur

  3. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Stuart K. Calderwood

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Wang, X., Rayalam, S., Bhave, V. (2016). Heat Shock Proteins and Phytochemicals: Role in Human Health and Disease. In: Asea, A., Kaur, P., Calderwood, S. (eds) Heat Shock Proteins and Plants. Heat Shock Proteins, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-319-46340-7_11

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