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Neuroregeneration

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Book cover Neurological Aspects of Spinal Cord Injury

Abstract

The last three decades of research in spinal cord injury have led to a better understanding of mechanisms underlying the regenerative failure in the adult mammalian central nervous system (CNS). Together with an enormous progress in cell and molecular biology, it now seems for the first time possible to develop novel therapeutic approaches that address factors extrinsic and intrinsic to injured neurons and their axons to promote functional recovery after spinal cord injury. Neutralizing inhibitors of axonal growth, delivery of growth factors and cellular transplants, and modulation of the axonal cytoskeleton and genetic and epigenetic programs after CNS trauma hold promise as new therapeutic avenues. In this chapter, we will discuss the preclinical rationale of some promising neuroregenerative approaches that have the potential to be translated into clinical trials or are currently in initial phases of clinical testing.

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Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft (BL414/3-1; SFB 1158), International Foundation for Research in Paraplegia, International Spinal Research Trust and the EU (IRG268282) to A. B., and a Gertrud Reemtsma Foundation predoctoral fellowship to I.S.

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  1. Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany

    Ina K. Simeonova

  2. Department of Neurological Surgery and Goodman Campbell Brain and Spine, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA

    Armin Blesch PhD

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  1. Ina K. Simeonova
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Correspondence to Armin Blesch PhD .

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  1. Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany

    Norbert Weidner

  2. Spinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany

    Rüdiger Rupp

  3. Methodist Rehabilitation Center, University of Mississippi Medical Center, Veterans Administration Medical Center, Jackson, Mississippi, USA

    Keith E. Tansey

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Simeonova, I.K., Blesch, A. (2017). Neuroregeneration. In: Weidner, N., Rupp, R., Tansey, K. (eds) Neurological Aspects of Spinal Cord Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-46293-6_21

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