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Nitrate and Nitrite in Aging and Age-Related Disease

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Book cover Nitrite and Nitrate in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

Abstract

Increasing age is associated with declines in multiple domains of physiological function leading to an increased risk of morbidity, disability, and mortality in older adults. Central to these declines in physiological function is a reduction in the bioavailability of the ubiquitous signaling molecule nitric oxide (NO). Supplementation with precursors of NO, nitrate, and nitrite, improves select vascular, physical, and cognitive functions in middle-aged and older adults and may improve age-associated inflammation and oxidative stress. Collectively, current evidence suggests that nitrate and nitrite supplementation represent promising therapeutic strategies for enhancing physiological function with aging and reducing the risk of age-associated disability and risk of chronic diseases.

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Authors and Affiliations

  1. Department of Integrative Physiology, University of Colorado Boulder, 354 UCB, Boulder, CO, 80309, USA

    Lawrence C. Johnson M.S. & Douglas R. Seals Ph.D.

  2. Medical College of Wisconsin, Cardiovascular Center, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA

    Allison E. DeVan Ph.D.

  3. Department of Internal Medicine—Geriatrics, Wake Forest School of Medicine, 1 Medical Center Blvd., Winston-Salem, NC, 27012, USA

    Jamie N. Justice Ph.D.

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  1. Lawrence C. Johnson M.S.
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  2. Allison E. DeVan Ph.D.
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  3. Jamie N. Justice Ph.D.
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  4. Douglas R. Seals Ph.D.
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Correspondence to Douglas R. Seals Ph.D. .

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  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

    Nathan S. Bryan

  2. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Loscalzo

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Johnson, L.C., DeVan, A.E., Justice, J.N., Seals, D.R. (2017). Nitrate and Nitrite in Aging and Age-Related Disease. In: Bryan, N., Loscalzo, J. (eds) Nitrite and Nitrate in Human Health and Disease. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46189-2_18

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