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Nitrite and Nitrate in Ischemia–Reperfusion Injury

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Nitrite and Nitrate in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Abstract

Ischemia–reperfusion injury occurs when blood supply is restored to a tissue or organ that was previously shut off from blood supply due to clots, trauma, or organ transplantation just to name a few. Protecting tissues and organs from this type of injury is critical for resulting organ function and patient outcomes. Both nitrite and nitrate have been found to be extremely protective in experimental animals in the setting of ischemia–reperfusion injury. Mechanistically it is even well defined as to how these two naturally occurring anions confer the level of protection. This chapter will highlight the effects of nitrite and nitrate on ischemia–reperfusion injury in a number of models and also illustrate the most recent clinical data on how this has translated into human patients.

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Disclosures

David J. Lefer (D.J.L.) is a participant on two pending United States Patents (patents no. 60/511244 and 61/003150) on the use of sodium nitrite in cardiovascular disease. Chelsea L. Organ has no disclosures. Nathan S. Bryan is an inventor on multiple issued US patents, receives royalties from patents from the University of Texas, is a Founder and Chief Science Officer for Neogenis Labs, Advisor and Stock owner for SAJE Pharma.

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Authors and Affiliations

  1. Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Center Science-New Orleans, 533 Bolivar Street, CSRB Room 408, New Orleans, LA, 70112, USA

    David J. Lefer Ph.D., Nathan S. Bryan Ph.D. & Chelsea L. Organ B.S.

  2. Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA

    David J. Lefer Ph.D., Nathan S. Bryan Ph.D. & Chelsea L. Organ B.S.

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  1. David J. Lefer Ph.D.
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  2. Nathan S. Bryan Ph.D.
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  3. Chelsea L. Organ B.S.
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Correspondence to David J. Lefer Ph.D. .

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Editors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

    Nathan S. Bryan

  2. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Loscalzo

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Lefer, D.J., Bryan, N.S., Organ, C.L. (2017). Nitrite and Nitrate in Ischemia–Reperfusion Injury. In: Bryan, N., Loscalzo, J. (eds) Nitrite and Nitrate in Human Health and Disease. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46189-2_16

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  • DOI: https://doi.org/10.1007/978-3-319-46189-2_16

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