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Lithium Response Variability (Pharmacogenomics Studies)

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Book cover The Science and Practice of Lithium Therapy

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Abstract

Lithium is considered to be the prototypical mood stabilizer. Naturalistic studies indicate that about one third of bipolar patients show a good or very good clinical response to lithium therapy. However, based on clinical evaluation, it remains difficult to reliably predict which patients are more likely to benefit from lithium therapy. In the era of personalized medicine, pharmacogenetics offers the hope that genetic markers could provide reliable predictors of individual responses to lithium therapy. As reviewed in this chapter, pharmacogenetic studies performed over the past two decades have unfortunately failed to produce predictive markers for lithium response that are meaningful for clinical practice. Lack of progress may be due to a variety of factors, including small sample sizes, clinical heterogeneity and variable definitions of lithium response versus non-response phenotypes. To circumvent these difficulties, large-scale international collaborative consortia are emerging, thus opening the possibility of performing genome-wide association studies on well-defined lithium-response phenotypes.

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Authors and Affiliations

  1. Mood Disorders Unit, Division of Psychiatric Specialties, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Rue de Lausanne 20bis, CH-1201, Geneva, Switzerland

    Alexandre Dayer MD

  2. TRE Program, Division of Psychiatric Specialties, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Rue de Lausanne 20bis, CH- 1201, Geneva, Switzerland

    Nader Perroud MD

  3. Division of Psychiatric Specialties, Department of Mental Health and Psychiatry, University Hospitals of Geneva, and Faculty of Medicine, University of Geneva, Rue de Lusanne 20bis, Geneva, 1201, Switzerland

    Jean-Michel Aubry MD

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  1. Alexandre Dayer MD
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  2. Nader Perroud MD
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  3. Jean-Michel Aubry MD
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Correspondence to Jean-Michel Aubry MD .

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Editors and Affiliations

  1. Academic Department of Psychiatry, Sydney Medical School The University of Sydney, Sydney, Australia

    Gin S. Malhi

  2. Nightingale Hospitals Paris-Clinique du Château de Garches, Consultant Service Hospitalo-Universitaire Centre Hospitalier Sainte-Anne, Paris, France

    Marc Masson

  3. Publique – Hôpitaux de Paris, INSERM UMR-S1144 Paris-Diderot University, Paris, France

    Frank Bellivier

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Dayer, A., Perroud, N., Aubry, JM. (2017). Lithium Response Variability (Pharmacogenomics Studies). In: Malhi, G., Masson, M., Bellivier, F. (eds) The Science and Practice of Lithium Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-45923-3_8

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