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Integrin-Mediated Interactions in Cartilage Physiology and Pathophysiology

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Cartilage

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Abstract

The development and homeostasis of cartilaginous tissues are regulated by diverse microenvironmental cues including integrin-mediated interactions between chondrocytes and the extracellular matrix (ECM). Integrins are membrane receptors responsible for bi-directional communication between the cells and the surrounding by transmitting physicochemical signals through adhesion complexes. In addition, integrins are involved in sensing mechanical stress signals generated by the ECM and transduce them into the cell interior converting physical stimuli to biochemical signaling. Integrin-activated signaling cascades modulate various chondrocyte functions and play important roles in cartilage morphogenesis, homeostasis, and repair. This chapter will summarize and discuss the role of integrins in the physiology and pathophysiology of the growth plate and articular cartilage.

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Acknowledgment

The author is supported by the DFG grants AS 150/11-1 (FOR2407) and AS 150/7-1.

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  1. Laboratory of Experimental Surgery and Regenerative Medicine, Clinic for General, Trauma and Reconstruction Surgery, Ludwig-Maximilians-University, Nussbaumstrasse 20, D-80336, Munich, Germany

    Attila Aszódi PhD

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  1. Attila Aszódi PhD
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Correspondence to Attila Aszódi PhD .

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  1. Orthopädische Klinik für die Universität Regensburg, Universitätsklinikum Regensburg, Regensburg, Germany

    Susanne Grässel

  2. Department of General, Trauma, and Reconstruction Surgery, Ludwig-Maximilians-University, Munich, Germany

    Attila Aszódi

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Aszódi, A. (2017). Integrin-Mediated Interactions in Cartilage Physiology and Pathophysiology. In: Grässel, S., Aszódi, A. (eds) Cartilage. Springer, Cham. https://doi.org/10.1007/978-3-319-45803-8_8

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