Abstract
Disorders in cardiac autonomic function have been implicated in several cardiac diseases. Use of positron emission tomography (PET)-based radiotracers to quantify changes in cardiac autonomic innervation has provided insights into the effect and impact of these alterations on disease pathophysiology and long-term implications. Understanding the use of different radiotracers to evaluate autonomic innervation requires an understanding of the biochemical components of the cardiac autonomic system (Fig. 5.1).
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References
Henze E, Huang SC, Ratib O, Hoffman E, Phelps ME, Schelbert HR. Measurements of regional tissue and blood-pool radiotracer concentrations from serial tomographic images of the heart. J Nucl Med. 1983;24(11):987–96.
Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979;3(3):299–308.
Luisi Jr AJ, Suzuki G, deKemp R, Haka MS, Toorongian SA, Canty Jr JM, Fallavollita JA. Regional 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction. J Nucl Med. 2005;46(8):1368–74.
Fallavollita JA, Heavey BM, Luisi Jr AJ, Michalek SM, Baldwa S, Mashtare Jr TL, Hutson AD, de Kemp RA, Haka MS, Sajjad M, Cimato TR, Curtis AB, Cain ME, Canty Jr JM. Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy. J Am Coll Cardiol. 2014;63:141–9. doi:10.1016/j.jacc.2013.07.096.
Caldwell JH, Kroll K, Li Z, Seymour K, Link JM, Krohn KA. Quantitation of presynaptic cardiac sympathetic function with carbon-11-meta-hydroxyephedrine. J Nucl Med. 1998;39(8):1327–34.
Delforge J, Syrota A, Lançon JP, Nakajima K, Loc’h C, Janier M, Vallois JM, Cayla J, Crouzel C. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177, and a new graphical method. J Nucl Med. 1991;32(4):739–48.
Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G. Cardiac beta-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling. Eur J Nucl Med Mol Imaging. 2012;39(8):1246–53. doi:10.1007/s00259-012-2138-4.
Delforge J, Mesangeau D, Dolle F, Merlet P, Loc’h C, Bottlaender M, Trebossen R, Syrota A. In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density. J Nucl Med. 2002;43(2):215–26.
Acknowledgments
We thank Robert deKemp, PhD, at the University of Ottawa for the use of FlowQuant® software, which has been used in our own PET research as well as some of the illustrations in this chapter. We also thank Anne Coe for her help with the preparation of the manuscript and figures.
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Fernandez, S.F., Canty, J.M., Fallavollita, J.A. (2017). PET Imaging and Quantitation of Cardiac Innervation. In: Dilsizian, V., Narula, J. (eds) Atlas of Cardiac Innervation. Springer, Cham. https://doi.org/10.1007/978-3-319-45800-7_5
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DOI: https://doi.org/10.1007/978-3-319-45800-7_5
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