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Phage-Mediated Immunomodulation

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Bacteriophage Applications - Historical Perspective and Future Potential

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

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Abstract

While the natural hosts for bacteriophages are bacteria, there is growing evidence for the ability of phage to interact with mammalian cells, particularly with those of the human immune system. These interactions typically encompass two main features: (i) phage immunogenicity, or ability of phages to induce specific immune responses; and (ii) phage immunomodulation, which can be defined as the ability of phages to modify the immune system in both innate and adaptive responses. The aim of this chapter is to explore the interactions between phages and the immune system, and more specifically the implications of these interactions in the development of novel medical applications.

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  1. School of Pharmacy, University of Waterloo, Waterloo, ON, Canada

    Jessica Nicastro, Shirley Wong & Roderick A. Slavcev

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  1. Jessica Nicastro
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Nicastro, J., Wong, S., Slavcev, R.A. (2016). Phage-Mediated Immunomodulation. In: Bacteriophage Applications - Historical Perspective and Future Potential. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-45791-8_7

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