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Radiation and Skin

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Environmental Radiation Effects on Mammals

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Abstract

Chapter 9 is devoted to the development and thorough study of the biologically motivated mathematical model, which describes the dynamics of the skin epidermis under the normal conditions and under single and fractionated irradiation. The model accounts for the principal stages of development of keratinocytes prevailing in this cell system, as well as peculiarities of its functioning. The model is implemented as the system of nonlinear differential equations, which variables and constant parameters have clear biological meaning. The identification and verification of the model are performed by making use of experimental data on the dynamics of the skin epidermis in young swine, which is regarded as the best animal model for the studies of the radiation effects on the human skin. It is shown that the developed model is capable of predicting the dynamics of skin epidermal cells in swine under normal conditions and under single and fractionated irradiation. It is demonstrated that the model is capable of predicting the dynamics of the moist desquamation in swine skin after single and fractionated irradiation proceeding from the dynamics of certain skin epidermal cells. The obtained modeling findings demonstrate that the developed model of the swine skin epidermis, after the appropriate identification, could be applied for predicting the radiation effects on the skin in humans (e.g., astronauts during long-term space missions such as voyages to Mars or lunar colonies, people exposed to radiation due to environmental radiological events, and patients treated with radiotherapy).

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Authors and Affiliations

  1. Research and Technical Center of Radiation-Chemical Safety and Hygiene, Moscow, Russian Federation

    Olga A. Smirnova

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  1. Olga A. Smirnova
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Smirnova, O.A. (2017). Radiation and Skin. In: Environmental Radiation Effects on Mammals. Springer, Cham. https://doi.org/10.1007/978-3-319-45761-1_9

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