Skip to main content
SpringerLink
Log in

Hidradenoma Papilliferum

  • Chapter
Cutaneous Adnexal Neoplasms

  • 3087 Accesses

Abstract

Hidradenoma papilliferum occurs mainly in adult women and appears as a solitary small papule or nodule of skin color with cystic appearance involving the vulva.

Histopathologically, the lesion shows a cystic configuration, with a large cavity lined by epithelium, to which are connected clustered and elongated tubules and long papillae. The papillae consist of a central axis of connective tissue lined by an epithelium composed of two layers of cells: a peripheral layer of cuboidal myoepithelial cells and a luminal layer of columnar cells, with evidence of decapitation secretion.

The epithelial cells lining the papillae express various cytokeratins, such as AE1/AE3 and CK5/6, as well as gross cystic disease fluid protein (GCDFP15). Peripheral myoepithelial cells of the double layer lining the papilla express the myoepithelial markers S-100 protein, calponin, and alpha-smooth muscle actin.

Recurrent mutations in PIK3CA and AKT1 are present in most cases.

Hidradenoma papilliferum is a benign neoplasm and simple excision is curative. Exceptional cases of hidradenocarcinoma papilliferum have originated in a pre-existing hidradenoma papilliferum.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Werth R. Zur Anatomie der Cysten der Vulva. Zentralb Gynakol. 1878;22:513–6.

    Google Scholar 

  2. Braun H. Ueber die Endothelioma der Haut. Arch Klin Chir. 1892;43:196–215.

    Google Scholar 

  3. Pick L. Ueber Hidradenoma und Adenoma hidradenoides. Virchows Arch [A]. 1904;175:312–64.

    Article  Google Scholar 

  4. Outerbridge GW. Sweat-gland tumors of the vulva (adenoma hidradenoides vulvae). Am J Obstet. 1915;62:32–46.

    Google Scholar 

  5. Eichenberg HE. Hidradenoma vulvae. Z Geburt Gynakol. 1934;109:358–73.

    Google Scholar 

  6. Folsome CE. Benign and malignant tumors of the vulva. JAMA. 1940;114:1499–503.

    Google Scholar 

  7. McDonald JR. Apocrine sweat gland carcinoma of the vulva. Am J Clin Pathol. 1941;11:890–7.

    Article  Google Scholar 

  8. McDonald JR, Lovelady SB, Waugh JM. Adenocarcinoma of the vulva. Am J Obstet Gynecol. 1941;42:304–9.

    Article  Google Scholar 

  9. Gates O, Warren S, Warvi WN. Tumors of sweat glands. Am J Pathol. 1943;19:591–631.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Cooper WL, McDonald JR. Adenoma of the apocrine sweat glands (hidradenoma) of the anal canal. Arch Pathol. 1944;38:155–7.

    Google Scholar 

  11. Teloh HA. Apocrine adenoma of the anus. Cancer. 1954;7:367–72.

    Article  CAS  PubMed  Google Scholar 

  12. Meeker JH, Neubecker RD, Helwig EB. Hidradenoma papilliferum. Am J Clin Pathol. 1962;37:182–95.

    Article  CAS  PubMed  Google Scholar 

  13. Mehregan AH. Apocrine cystadenoma. A clinicopathologic study with special reference to the pigmented variety. Arch Dermatol. 1964;90:274–9.

    Article  CAS  PubMed  Google Scholar 

  14. Ioannides G. Hidradenoma papilliferum. Am J Obstet Gynecol. 1966;94:849–53.

    CAS  PubMed  Google Scholar 

  15. Tappeiner J, Wolff K. Hidradenoma papilliferum. Eine enzymhistochemische und elektronenmikrosckpische Studie. Hautartz. 1968;19:101–9.

    CAS  Google Scholar 

  16. Danforth WC. Sweat gland tumors of the vulva. Am J Obstet Gynecol. 1949;58:326–34.

    Article  CAS  PubMed  Google Scholar 

  17. Vang R, Cohen PR. Ectopic hidradenoma papilliferum: a case report and review of the literature. J Am Acad Dermatol. 1999;41:115–8.

    Article  CAS  PubMed  Google Scholar 

  18. Binns JH. A rare case of hidradenoma papilliferum report of a case and review of the literature. Br J Plast Surg. 1974;27:367–9.

    Article  CAS  PubMed  Google Scholar 

  19. Santa Cruz DJ, Prioleau PG, Smith ME. Hidradenoma papilliferum of the eyelid. Arch Dermatol. 1981;117:55–6.

    Article  CAS  PubMed  Google Scholar 

  20. Nissim F, Czernobilsky B, Ostfeld E. Hidradenoma papilliferum of the external auditory canal. J Laryngol Otol. 1981;95:843–8.

    Article  CAS  PubMed  Google Scholar 

  21. Goette DK. Hidradenoma papilliferum. J Am Acad Dermatol. 1988;19:133–5.

    Google Scholar 

  22. Veraldi S, Schianchi-Veraldi R, Marini D. Hidradenoma papilliferum of the vulva: report of a case characterized by unusual clinical behavior. J Dermatol Surg Oncol. 1990;16:674–6.

    Article  CAS  PubMed  Google Scholar 

  23. Virgili A, Marzola A, Corazza M. Vulvar hidradenoma papilliferum. A review of 10.5 years’ experience. J Reprod Med. 2000;45:616–8.

    CAS  PubMed  Google Scholar 

  24. Moon JW, Na CH, Kim HR, Shin BS. Giant ectopic hidradenoma papilliferum on the scalp. J Dermatol. 2009;36:545–7.

    Article  PubMed  Google Scholar 

  25. Lee EJ, Shin MK, Haw CR, Lee MH. Two cases of hidradenoma papilliferum of the nose. Acta Derm Venereol. 2010;90:322–3.

    Article  PubMed  Google Scholar 

  26. Lee HJ, Lee D, Jung SY, Hong SK, Seo JK, Sung HS. Hidradenoma papilliferum occurring on the nasal skin. Ann Dermatol. 2011;23(Suppl 2):S254–7.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Kim YJ, Lee JW, Choi SJ, Kim SJ, Kim YJ, Jeon YS, Lee KH. Ectopic hidradenoma papilliferum of the breast: ultrasound finding. J Breast Cancer. 2011;14:153–5.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Morimura S, Kadono T, Sugaya M, Sato S. Ectopic hidradenoma papilliferum on the abdomen. Eur J Dermatol. 2011;21:278–9.

    PubMed  Google Scholar 

  29. Woodworth Jr H, Dockerty MB, Wilson RB, et al. Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. Am J Obstet Gynecol. 1971;110:501–8.

    Article  PubMed  Google Scholar 

  30. Stefanato CM, Finn R, Bhawan J. Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? Am J Dermatopathol. 2000;22:439–42.

    Article  CAS  PubMed  Google Scholar 

  31. Simpson WA, Burke M, Frappell J, Cook MG. Paget’s disease, melanocytic neoplasia and hidradenoma papilliferum of the vulva. Histopathology. 1988;12:675–9.

    Article  CAS  PubMed  Google Scholar 

  32. Kazakov DV, Mikyskova I, Kutzner H, Simpson RH, Hes O, Mukensnabl P, Bouda J, Zamecnik M, Kinkor Z, Michal M. Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. Am J Dermatopathol. 2005;27:102–10.

    Article  PubMed  Google Scholar 

  33. Minami S, Sadanobu N, Ito T, Natsuaki M, Yamanishi K. Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases. J Dermatol. 2006;33:256–9.

    Article  PubMed  Google Scholar 

  34. Fernandez-Flores A, Valerdiz S. Pseudocarcinomatous hyperplasia associated with hidradenoma papilliferum. Am J Dermatopathol. 2012;34:e31–6.

    Article  PubMed  Google Scholar 

  35. Parks A, Branch KD, Metcalf J, Underwood P, Young J. Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. Am J Dermatopathol. 2012;34:104–9.

    Article  PubMed  Google Scholar 

  36. Konstantinova AM, Kacerovska D, Michal M, Kazakov DV. A composite neoplastic lesion of the vulva with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia containing multinucleated giant cells. Am J Dermatopathol. 2014;36:e171–4.

    Article  PubMed  Google Scholar 

  37. Sington J, Chandrapala R, Manek S, Hollowood K. Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases. Am J Dermatopathol. 2006;28:322–6.

    Article  PubMed  Google Scholar 

  38. Lever WF. Pathogenesis of benign tumors of cutaneous appendages and basal cell epithelioma. I. Benign tumors of the cutaneous appendages. Arch Dermatol Syph. 1948;57:679–708.

    Article  CAS  Google Scholar 

  39. Grund JL, McNicol CA. Apocrine hamartomas. USAF Med J. 1950;1:1489–94.

    CAS  Google Scholar 

  40. Cunningham JA, Hardy J. Hidradenomas of the vulva. South Surg. 1947;13:831–8.

    Google Scholar 

  41. Offidani A, Campanati A. Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. J Clin Pathol. 1999;52:829–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Novak E, Stevenson RR. Sweat gland tumors of the vulva, benign (hidradenoma) and malignant (adenocarcinoma). Am J Obstet Gynecol. 1945;501:641–59.

    Article  Google Scholar 

  43. Mahalingam M, Srivastava A, Hoang MP. Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol. 2010;32:774–9.

    Article  PubMed  Google Scholar 

  44. Pfarr N, Sinn HP, Klauschen F, et al. Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma. Genes Chromosomes Cancer. 2016;55:113–9.

    Article  CAS  PubMed  Google Scholar 

  45. Stout AP, Cooley SGE. Carcinoma of sweat glands. Cancer. 1951;4:521–36.

    Article  CAS  PubMed  Google Scholar 

  46. Vazmitel M, Spagnolo DV, Nemcova J, Michal M, Kazakov DV. Hidradenoma papilliferum with a ductal carcinoma in situ component: case report and review of the literature. Am J Dermatopathol. 2008;30:392–4.

    Article  PubMed  Google Scholar 

  47. Bannatyne P, Elliott P, Russell P. Vulvar adenosquamous carcinoma arising in a hidradenoma papilliferum, with rapidly fatal outcome: case report. Gynecol Oncol. 1989;35:395–8.

    Article  CAS  PubMed  Google Scholar 

  48. Barré C, Lorenzato M, Bourdat B, Quéreux C, Durlach A. Carcinome epidermoide et hidradenome papillifere vulvaire. A propos d’un cas. Gynecol Obstet Fertil. 2007;35:776–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

Authors
  1. Luis Requena
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Omar Sangüeza
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Requena, L., Sangüeza, O. (2017). Hidradenoma Papilliferum. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-45704-8_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45703-1

  • Online ISBN: 978-3-319-45704-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation