Abstract
Secretory carcinoma of the skin has not any distinctive clinical feature, and it may appear in any location.
Histopathologically, the intraductal and invasive components are composed of aggregates of epithelial cells with microlumens containing eosinophilic secretion. Neoplastic cells show monomorphous round nuclei and pink vacuolated cytoplasm. Mitotic figures are scarce or absent.
Immunohistochemically, neoplastic cells express S-100 protein and epidermal growth factor receptor, but they are negative for CEA, p53, and HER-2. Myoepithelial cells surrounding the intraductal carcinoma express p63, calponin, and SMA.
Gene analysis has demonstrated the ETV6-NTRK3 fusion gene, identical to that of secretory carcinoma of the breast and salivary glands.
Secretory carcinoma of the skin has low metastatic potential.
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Requena, L., Sangüeza, O. (2017). Secretory Carcinoma of the Skin. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_31
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DOI: https://doi.org/10.1007/978-3-319-45704-8_31
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