Abstract
Primary cutaneous cribriform carcinoma seems to be more common in the upper and lower extremities.
Histopathologically this neoplasm shows a well-circumscribed nodular morphology and is composed of epithelial aggregates occupying the dermis sprinkled by small holes. Individual neoplastic cells have a large, rounded, and pleomorphic nuclei surrounded by a scant eosinophilic cytoplasm. In contrast with adenoid cystic carcinoma, neurotropism is not usually seen in cribriform carcinoma.
Immunohistochemically, neoplastic cells of cribriform carcinoma express immunoreactivity for MNF116, AE1/AE3, CAM 5.2, cytokeratin 5/6, cytokeratin 7, CEA, and EMA.
Primary cutaneous cribriform carcinoma is a locally destructive neoplasm, but no metastases from this tumor have been described.
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Requena, L., Sangüeza, O. (2017). Cribriform Carcinoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_28
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DOI: https://doi.org/10.1007/978-3-319-45704-8_28
Publisher Name: Springer, Cham
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