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Adenoid–Cystic Carcinoma

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Cutaneous Adnexal Neoplasms

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Abstract

Primary cutaneous adenoid–cystic carcinoma involves more frequently the scalp of adult and elderly patients.

Adenoid–cystic carcinoma is composed of epithelial collections of basaloid cells, which are arranged in an alternating pattern of solid and cribriform areas. The neoplasm also features true ductal formations, although only in small number. Perineural involvement is frequent in deeper areas.

Immunohistochemical studies show positivity for CEA and EMA in the tubular formation, whereas neoplastic cells express CD177 as well as cytokeratins of the stratified epithelium (CK1/5/10/14), as well cytokeratins of simple epithelium (CK7/8/18/19).

Myoepithelial cells express S-100 protein, smooth muscle actin, and calponin.

Primary cutaneous adenoid–cystic carcinoma is a low-grade malignancy, which is locally destructive, but has little capacity for distant metastases.

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Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

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  1. Luis Requena
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  2. Omar Sangüeza
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Requena, L., Sangüeza, O. (2017). Adenoid–Cystic Carcinoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_27

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  • DOI: https://doi.org/10.1007/978-3-319-45704-8_27

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45703-1

  • Online ISBN: 978-3-319-45704-8

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