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Cylindrocarcinoma and Spiradenocarcinoma

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Cutaneous Adnexal Neoplasms

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Abstract

Multiple cylindromas on the scalp seems to be the most common predisposing factor for the development of a cylindrocarcinoma. The diagnosis of cylindrocarcinoma or spiradenocarcinoma should be suspected when sudden rapid growth occurs in a pre-existing long-standing lesion.

Histopathologically, neoplastic aggregates of cylindrocarcinoma show great variability in shape and size, large areas of necrosis en masse, and loss of the thick and eosinophilic basement membrane surrounding the neoplastic aggregations, and the nuclei of the neoplastic cells are piled up, with frequent mitotic figures and nuclear pleomorphism. Poorly differentiated spiradenocarcinomas show little resemblance to spiradenoma, and the diagnosis of spiradenocarcinoma can only be made with certainty when there are remains of a spiradenoma in the vicinity. Undifferentiated cases of spiradenocarcinoma may show sarcomatous appearance.

Immunohistochemical studies in cylindrocarcinoma and spiradenocarcinoma have shown positivity of neoplastic cells for CK7 and SMA, with variable results for CAM 5.2, CEA, EMA, and S100 protein.

Cylindrocarcinoma and spiradenocarcinoma are highly aggressive neoplasms, and Mohs microsurgery has been proposed as the best therapy.

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Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

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  1. Luis Requena
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  2. Omar Sangüeza
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Requena, L., Sangüeza, O. (2017). Cylindrocarcinoma and Spiradenocarcinoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_23

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  • DOI: https://doi.org/10.1007/978-3-319-45704-8_23

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45703-1

  • Online ISBN: 978-3-319-45704-8

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