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Apocrine Hidradenocarcinoma

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Cutaneous Adnexal Neoplasms

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Abstract

Apocrine hidradenocarcinoma appears as an asymptomatic subcutaneous nodule in any area of the body surface.

Histopathologically, apocrine hidradenocarcinoma is a multilobulated neoplasm, with solid aggregates of neoplastic cells that vary in shape and size and infiltrate the dermis.

Neoplastic cells of apocrine hidradenocarcinoma may be clear cells, pale cells, squamous cells, polygonal cells, oncocytoid cells, or mucinous cells, with variable proportions among these cells from case to case. Nuclear pleomorphism, mitotic figures, and the degree of atypia may be very striking. The stroma is composed of sclerotic collagen bundles.

Immunohistochemistry demonstrates positivity for CAM 5.2, AE1/AE3, CK5/CK6/CK7/CK19, EMA, CEA, S-100 protein, bcl-1, bcl-2, p63, androgen receptor, EGFR, estrogen receptor, MUC5AC, and p53 in neoplastic cells.

Apocrine hidradenocarcinoma is an aggressive neoplasm, and it should be excised with wide clear margins.

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Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

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  1. Luis Requena
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  2. Omar Sangüeza
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Requena, L., Sangüeza, O. (2017). Apocrine Hidradenocarcinoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_20

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  • DOI: https://doi.org/10.1007/978-3-319-45704-8_20

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45703-1

  • Online ISBN: 978-3-319-45704-8

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