Abstract
The most frequent presentation of syringomas is as small papules on the lower eyelids.
The so-called eruptive variant of syringomas consists of a multitude of small papules, scattered over the anterior wall of the chest
Histopathologically, syringoma is constituted by a double component: epithelial ducts and cysts and a stroma, represented by a homogeneous and sclerotic collagen. The ducts are lined by a double layer of cuboidal cells which delimit a luminal space, and often they show a characteristic epithelial extension resembling a “tadpole tail.” The cysts are filled with basket-weave, basophilic, and orthokeratotic keratin and lined by squamous epithelium with a granular layer.
Clear-cell syringoma is more common in diabetics and is histopathologically characterized by ducts and solid aggregates of epithelial cells with a clear cytoplasm, due to glycogen deposition.
Immunohistochemical studies show carcinoembryonic antigen positivity in the luminal border of the tubules and of many of the small keratinous cysts, whereas they do not express GCDFP-15.
Syringomas are quite benign lesions.
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Requena, L., Sangüeza, O. (2017). Syringoma. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_15
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