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Mixed Tumors of the Skin

  • Chapter
Cutaneous Adnexal Neoplasms

Abstract

Most cutaneous mixed tumors appear as a solitary lesion in middle-aged adults, and the scalp and face are the most common locations.

There are two histopathologic variants of cutaneous mixed tumors. Apocrine mixed tumor shows elongated and branched tubules lined by two layers of epithelial cells and a mesenchymal stroma that may be mucinous, chondroid, osteoid, or a mixture. These two epithelial layers consist of a peripheral layer of cuboidal cells and an inner layer formed by columnar cells. In some areas the luminal layer shows decapitation secretion. The eccrine variant of cutaneous mixed tumor is rarer, and it is made up of numerous small ducts of circular morphology lined by a single layer of epithelial cells.

Immunohistochemically, positivity for CK7 and Ber-EP4 is seen in the epithelial cells lining tubular structures, whereas myoepithelial cells express immunoreactivity for SMA, p63, calponin, S-100 protein, and SOX10, but these cells are absent in the eccrine variant.

Gene rearrangement for PLAG1 and for EWSR1 has been demonstrated in most cutaneous mixed tumors.

Cutaneous mixed tumors are benign neoplasms. Most malignant cases originate de novo.

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Authors and Affiliations

  1. Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

    Luis Requena

  2. Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA

    Omar Sangüeza

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  1. Luis Requena
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  2. Omar Sangüeza
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Requena, L., Sangüeza, O. (2017). Mixed Tumors of the Skin. In: Cutaneous Adnexal Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-45704-8_11

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  • DOI: https://doi.org/10.1007/978-3-319-45704-8_11

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45703-1

  • Online ISBN: 978-3-319-45704-8

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