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Stimulus Responsive Graphene Scaffolds for Tissue Engineering

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Book cover Graphene-based Materials in Health and Environment

Part of the book series: Carbon Nanostructures ((CARBON))

Abstract

Tissue engineering (TE) is an emerging area that aims to repair damaged tissues and organs by combining different scaffold materials with living cells. Recently, scientists started to engineer a new generation of nanocomposite scaffolds able to mimic biochemical and biophysical mechanisms to modulate the cellular responses promoting the restoration of tissue structure or function. Due to its unique electrical, topographical and chemical properties, graphene is a material that holds a great potential for TE, being already considered as one of the best candidates for accelerating and guiding stem cell differentiations. Although this is a promising field there are still some challenges to overcome, such as the efficient control of the differentiation of the stem cells, especially in graphene-based microenvironments. Hence, this chapter will review the existing research related to the ability of graphene and its derivatives (graphene oxide and reduced graphene oxide) to induce stem cell differentiation into diverse lineages when under the influence of electrical, mechanical, optical and topographic stimulations.

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Acknowledgments

Sofia S. Almeida thanks the Mobility Program: Programme Almeida Garret—Studies during the Academic Year 2015/2016. PAAP Marques thank the Portuguese Foundation for Science and Technology (FCT) for the investigator grant (IF/00917/2013) and for the Project IF/00917/2013/CP1162/CT0016 which supports the researcher grant of André Girão. Gil Gonçalves thank FCT for respectively the grants SFRH/BDP/84419/2012. This work was partially supported by the funding of Program COMPETE-FEDER, Programa Operacional Competitividade e Internacionalização through the Project POCI-01-0145-FEDER-016574 and by FCT, IP through the Project PTDC/EMS-TEC/3263/2014.

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Authors and Affiliations

  1. Faculty of Engineering, University of Porto, Porto, Portugal

    Sofia S. Almeida

  2. TEMA, Mechanical Engineering Department, University of Aveiro, Aveiro, Portugal

    André F. Girão, Gil Gonçalves, António Completo & P. A. A. P. Marques

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  1. Sofia S. Almeida
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  2. André F. Girão
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  3. Gil Gonçalves
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  4. António Completo
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  5. P. A. A. P. Marques
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Correspondence to Sofia S. Almeida or P. A. A. P. Marques .

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Editors and Affiliations

  1. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Gil Gonçalves

  2. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Paula Marques

  3. Nanoengineering Research Division, Department of Mechanical Engineering, Centre for Mechanical Technology and Automation, University of Aveiro, Aveiro, Portugal

    Mercedes Vila

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Almeida, S.S., Girão, A.F., Gonçalves, G., Completo, A., Marques, P.A.A.P. (2016). Stimulus Responsive Graphene Scaffolds for Tissue Engineering. In: Gonçalves , G., Marques, P., Vila, M. (eds) Graphene-based Materials in Health and Environment. Carbon Nanostructures. Springer, Cham. https://doi.org/10.1007/978-3-319-45639-3_8

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