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The Role of Cancer Stem Cells in Tumour Radioresponse

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Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

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Abstract

In order to achieve complete tumour cure after radiotherapy, it is mandatory that all cancer stem cells (CSCs) are being killed. Therefore, new anti-cancer treatments should not only be directed against the bulk of the tumour but also have to target those tumour cells, which are expressing putative CSC markers since they highly determine tumour radioresistance as discussed in this chapter. This is further being influenced by other factors such as the tumour microenvironment, epithelial-mesenchymal transition as well as changes during the course of radio(chemo)therapy. Together with established parameters such as the tumour volume for primary radio(chemo)therapy or the human papilloma virus infection status for head and neck squamous cell carcinoma, the utilization of putative CSC markers may help to predict radiotherapy outcome and allow for patient stratification for individualized treatment strategies.

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Author information

Authors and Affiliations

  1. German Cancer Center (DKFZ), Heidelberg, Germany

    Annett Linge, Anna Dubrovska, Michael Baumann & Mechthild Krause

  2. Department for Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany

    Annett Linge, Michael Baumann & Mechthild Krause

  3. Faculty of Medicine, OncoRay—National Center for Radiation Research in Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

    Annett Linge, Anna Dubrovska, Michael Baumann & Mechthild Krause

  4. National Center for Tumour Diseases (NCT), Dresden, Germany

    Annett Linge, Michael Baumann & Mechthild Krause

  5. Helmholtz-Zentrum Dresden—Rossendorf, Institute for Radiooncology, Dresden, Germany

    Michael Baumann & Mechthild Krause

Authors
  1. Annett Linge
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  2. Anna Dubrovska
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  3. Michael Baumann
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  4. Mechthild Krause
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Corresponding author

Correspondence to Annett Linge .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Mitchell S. Anscher

  2. Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Kristoffer Valerie

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© 2016 Springer International Publishing Switzerland

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Linge, A., Dubrovska, A., Baumann, M., Krause, M. (2016). The Role of Cancer Stem Cells in Tumour Radioresponse. In: Anscher, M., Valerie, K. (eds) Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Springer, Cham. https://doi.org/10.1007/978-3-319-45594-5_3

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