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Host Response to Implanted Materials and Devices: An Overview

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The Immune Response to Implanted Materials and Devices

Abstract

The host response to implanted materials and devices is influenced not only by the design of the material itself, but also by the local and systemic environment of the host. Much of the early response follows the well-described cascade of events of wound healing from hemostasis to scar formation. An implanted material can positively or negatively modulate this cascade of events, culminating in a constructive remodeling response, a persistent inflammatory response, a foreign body response with encapsulation, or an adaptive immune response. An overview of these events, as well as the influence of biologic versus synthetic materials, is discussed in this chapter.

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Authors and Affiliations

  1. McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA, 15219, USA

    Michelle E. Scarritt, Ricardo Londono & Stephen F. Badylak

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  1. Michelle E. Scarritt
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  2. Ricardo Londono
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  3. Stephen F. Badylak
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Correspondence to Stephen F. Badylak .

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Editors and Affiliations

  1. Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy

    Bruna Corradetti

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Scarritt, M.E., Londono, R., Badylak, S.F. (2017). Host Response to Implanted Materials and Devices: An Overview. In: Corradetti, B. (eds) The Immune Response to Implanted Materials and Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-45433-7_1

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