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Pancreatic Islet Biology pp 217–240Cite as

Generation of Human Islet Progenitor Cells via Epithelial-to-Mesenchymal Transition

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Epithelial to mesenchymal transition (EMT) has been shown to occur during generation of human islet-derived progenitor cells (hIPCs), which have been demonstrated to retain potential to differentiate into insulin-producing cells. EMT is a biological process where epithelial cells go through a phenotypic change to become more mesenchymal-like. EMT is reported to form the basis of three distinct physiological and pathological processes: embryo formation/implantation, tissue repair and carcinoma/metastasis. We demonstrated that human islets undergo EMT when exposed to growth-promoting conditions in vitro. Here, we provide an overview of EMT, generation of hIPCs and other stem cells with this phenomenon, the debate surrounding the origin of lineage-committed progenitor cells and finally the role of microRNAs in regulating EMT in hIPCs.

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  1. Diabetes and Islet Biology Group, NHMRC Clinical Trials Centre, Faculty of Medicine, The University of Sydney, Level 6, Medical Foundation Building, 92-94 Parramatta Road, Camperdown, NSW, 2050, Australia

    Wilson Wong, Anandwardhan A. Hardikar & Mugdha V. Joglekar

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Correspondence to Mugdha V. Joglekar .

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  1. NHMRC Clinical Trials Centre Diabetes and Islet-biology Group, The University of Sydney Faculty of Medicine, Sydney, New South Wales, Australia

    Anandwardhan A. Hardikar

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Wong, W., Hardikar, A.A., Joglekar, M.V. (2016). Generation of Human Islet Progenitor Cells via Epithelial-to-Mesenchymal Transition. In: A. Hardikar, A. (eds) Pancreatic Islet Biology. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-45307-1_9

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