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Exploration of Autoimmune Diseases Using Multi-agent Systems

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Computational Collective Intelligence (ICCCI 2016)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 9876))

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Abstract

Autoimmune disease is a group of pathological events identified by abnormal reactions of the immune system against self-structures of the organism. Pathogenesis of autoimmune diseases is multi-factorial. Genetics, infections, and environmental factors can support the progress of the autoimmunity. We investigated this mechanism using in vivo or in vitro approaches. Main aim of this manuscript is to explore the autoimmunity with in-silico approach - multi-agent systems. The preliminary research finds out which results can be acquired using factual data applied for building the multi-agent-based model. Preliminary computational model integrates one of the common aspects of autoimmune diseases - abnormal behaviour of B-cells during their organogenesis.

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Acknowledgements

The support of the Specific research project at FIM UHK and Czech Science Foundation project Nr. 14-02424S is gratefully acknowledged.

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Authors and Affiliations

  1. Faculty of Informatics and Management, University of Hradec Králové, Hradec Králové, Czech Republic

    Richard Cimler & Martina Husáková

  2. Center for Basic and Applied Research (CZAV), University of Hradec Králové, Hradec Králové, Czech Republic

    Richard Cimler

  3. Faculty of Medicine, Department of Clinical Immunology and Allergy, Charles University, Hradec Králové, Czech Republic

    Martina Koláčková

Authors
  1. Richard Cimler
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  2. Martina Husáková
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  3. Martina Koláčková
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Corresponding author

Correspondence to Martina Husáková .

Editor information

Editors and Affiliations

  1. Wroclaw University of Technology , Wroclaw, Poland

    Ngoc Thanh Nguyen

  2. Aristotle University of Thessaloniki , Thessaloniki, Greece

    Lazaros Iliadis

  3. Department of Forestry and Manageme, Democritus University of Thrace Department of Forestry and Manageme, Orestiada Thrace, Greece

    Yannis Manolopoulos

  4. Wrocław University of Technology , Wrocław, Poland

    Bogdan Trawiński

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Cimler, R., Husáková, M., Koláčková, M. (2016). Exploration of Autoimmune Diseases Using Multi-agent Systems. In: Nguyen, N., Iliadis, L., Manolopoulos, Y., Trawiński, B. (eds) Computational Collective Intelligence. ICCCI 2016. Lecture Notes in Computer Science(), vol 9876. Springer, Cham. https://doi.org/10.1007/978-3-319-45246-3_27

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  • DOI: https://doi.org/10.1007/978-3-319-45246-3_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-45245-6

  • Online ISBN: 978-3-319-45246-3

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