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A Role for Autoimmunity in the Immune Response Against Malaria

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Malaria

Chapter Summary

Malaria, like other infectious diseases, leads to the development of autoimmunity. Multiple studies have reported various features of autoimmunity during malaria, such as polyclonal activation and autoantibody production. Autoimmunity during malaria has been hypothesized to play a role in parasite control and clearance. Conversely, autoimmunity has also been implied in contributing to most of the pathologies observed during complicated malaria. Autoimmune diseases shared many clinical and pathology features associated with clinical malaria. Genetic evidence has even suggested evolutionary links between the development of autoimmune disease and protections against clinical malaria. Although the presence of autoimmunity during malaria and other infections has been extensively reported, mechanistic insights and efforts to understand its role have proven to be challenging. The recent advancements achieved in understanding other autoimmune disorders can aid in understanding the presence and role of autoimmunity during infection. In this chapter, we aim to discuss the role that autoimmunity may play in both malaria protection and pathology. We also discuss various genetic and mechanistic evidences supporting the link between malaria and autoimmune diseases. Lastly, we conclude summarizing the evidence of autoimmunity during infection.

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Authors and Affiliations

  1. Division of Parasitology, Department of Microbiology, New York University School of Medicine, New York, NY, 10010, USA

    Juan Rivera-Correa & Ana Rodriguez

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  1. Juan Rivera-Correa
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  2. Ana Rodriguez
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  1. Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal

    Maria M. Mota

  2. Division of Parasitology, Department of Microbiology, New York University School of Medicine, New York, New York, USA

    Ana Rodriguez

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Rivera-Correa, J., Rodriguez, A. (2017). A Role for Autoimmunity in the Immune Response Against Malaria. In: Mota, M., Rodriguez, A. (eds) Malaria. Springer, Cham. https://doi.org/10.1007/978-3-319-45210-4_5

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