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Integration Host Factor (IHF)–DNA Interaction

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Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition

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Abstract

Integration host factor (IHF) is a small hetero dimeric protein (~20 kDa), ubiquitous in eubacteria. It binds to DNA in a sequence-specific manner and causes ~35-bp long cognate site of DNA to bend by >160° [1]. Even though IHF was first discovered as a host factor for bacteriophage λ integration, where λ phage cleverly facilitates its E. coli host’s protein IHF to infest its target, IHF also aids in chromosomal compaction as well as in the assembly of higher order nucleo-protein complexes necessary for replication initiation, some site-specific recombination and transcriptional regulation of certain genes [2, 3].

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  1. University of Illinois at Chicago, Chicago, IL, USA

    Yogambigai Velmurugu

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Velmurugu, Y. (2017). Integration Host Factor (IHF)–DNA Interaction. In: Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-45129-9_3

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