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Basic Studies in Antimicrobial PDT

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Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice

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Abstract

Microorganisms (MO) multiply rapidly and mutations that guarantee its survival forward to antimicrobials become prevalent in new populations. The inexorable rise of multidrug-resistant MO leads to an effort to search for alternative approaches that, hypothetically, MO could not easily develop resistance. Antimicrobial photodynamic therapy (PDT) is an effective alternative treatment for infected lesions in animals. The goal of the technique is to destroy a sufficient number of pathogenic MO to prevent recolonization and avoid unacceptable destruction of the host tissue. An important observation concerns the selectivity of the photosensitizer by microbial cells when compared to the host. This is because the photosensitizer (PS) uptake by host cells is slower than by MO. If the site of infection is irradiated after a short interval from the PS application (minutes), the damage to host tissue is minimized. Currently, antimicrobial PDT has proven its effectiveness against bacteria, virus, fungi, and parasites. This chapter reviews the literature regarding antimicrobial PDT especially for veterinary medicine.

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Author information

Authors and Affiliations

  1. Veterinary Unit of Santos Aquarium, Santos Aquarium, Ponta da Praia, Santos, Brazil

    Cristiane Lassálvia Nascimento

  2. Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, Butantã, São Paulo, SP, Brazil

    Fábio Parra Sellera

  3. Center for Lasers and Applications, Nuclear and Energy Research Institute, National Commission for Nuclear Energy, São Paulo, SP, Brazil

    Martha Simões Ribeiro

Authors
  1. Cristiane Lassálvia Nascimento
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  2. Fábio Parra Sellera
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  3. Martha Simões Ribeiro
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Corresponding author

Correspondence to Cristiane Lassálvia Nascimento .

Editor information

Editors and Affiliations

  1. University of São Paulo, Department of Internal Medicine, School of Veterinary Medicine and Animal Science, Butantã, São Paulo, Brazil

    Fábio Parra Sellera

  2. Santos Aquarium, Veterinary Unit of Santos Aquarium, Ponta da Praia, Santos, São Paulo, Brazil

    Cristiane Lassálvia Nascimento

  3. IPEN-CNEN/SP, Center for Lasers and Applications, Cidade Universitária, São Paulo, São Paulo, Brazil

    Martha Simões Ribeiro

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© 2016 Springer International Publishing Switzerland

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Nascimento, C.L., Sellera, F.P., Ribeiro, M.S. (2016). Basic Studies in Antimicrobial PDT. In: Sellera, F., Nascimento, C., Ribeiro, M. (eds) Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-45007-0_11

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