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Innovations in Molecular Mechanisms and Tissue Engineering pp 101–119Cite as

Cellular Approaches to Adult Mammalian Heart Regeneration

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Adult mammalian hearts lack significant regenerative potential, partially explaining why cardiomyopathies are a major cause of human death in the world. By contrast, adult lower vertebrates and neonatal mice can regenerate their heart after ischemic or physical injury. Significant efforts over the last several decades have led to advances in the understanding of cardiac biology and mechanisms of natural regeneration. For example, genetic lineage tracing evidence has shown that regenerative species use the expansion of pre-existing differentiated cardiomyocytes as a source of new myocardium. However, despite promising developments in basic science, therapeutic outcomes are modest with currently available therapy, underscoring the need for further discovery and translational research. Here, we review recent progress in the pursuit of human heart regeneration with a focus on cellular approaches. Highlights include somatic cell reprogramming, improved cardiac differentiation protocols, and a plethora of clinical trials, with some showing improvement in functional recovery after myocardial infarction.

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Authors and Affiliations

  1. Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Blvd S., SC 382 K, San Francisco, CA, 94158, USA

    Justin Judd

  2. Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Blvd S., SC 382 K, San Francisco, CA, 94158, USA

    Guo N. Huang

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  1. Justin Judd
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Correspondence to Guo N. Huang .

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  1. School of Life Sciences Arizona State University, Tempe, Arizona, USA

    Jeanne Wilson-Rawls

  2. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA

    Kenro Kusumi

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Judd, J., Huang, G.N. (2016). Cellular Approaches to Adult Mammalian Heart Regeneration. In: Wilson-Rawls, J., Kusumi, K. (eds) Innovations in Molecular Mechanisms and Tissue Engineering. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-44996-8_6

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