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Health Informatics Data Analysis pp 51–60Cite as

Identification and Functional Annotation of LncRNAs in Human Disease

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Part of the book series: Health Information Science ((HIS))

Abstract

Accumulated evidence suggests that long noncoding RNAs (lncRNAS) play a key role in most of the biological processes. By the advance of sequencing technology, more and more lncRNAs are identified. However, only a few has known functions. It is still a challenge to annotate the functions of lncRNAs for both bioinformaticians and biologists. In this chapter, we gave a comprehensive review of the current bioinformatics methods to identify lncRNAs and annotate their functions in mammals. The identification of lncRNAs was mainly based on the technologies of microarray and RNA-seq. While for the functional annotations of lncRNAs, a method based on the co-expression network of both coding and noncoding genes was illustrated. We also reviewed several ways to analyze the interactions between lncRNAs and targets such as miRNAs and protein-coding genes. An example of identifying and annotating human lncRNAs was given to illustrate the whole process.

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Authors and Affiliations

  1. Key Lab of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, 100190, Beijing, China

    Qi Liao, Dechao Bu, Liang Sun, Haitao Luo & Yi Zhao

  2. Department of Preventative Medicine, School of Medicine, Ningbo University, 315211, Ningbo, Zhejiang, China

    Qi Liao

Authors
  1. Qi Liao
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  2. Dechao Bu
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  3. Liang Sun
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  4. Haitao Luo
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  5. Yi Zhao
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Corresponding author

Correspondence to Qi Liao .

Editor information

Editors and Affiliations

  1. Digital Biology Laboratory, Computer Science Department, University of Missouri-Columbia, Columbia, Missouri, USA

    Dong Xu

  2. Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA

    May D. Wang

  3. College of Computer Science and Technology, Jilin University, Changchun, China

    Fengfeng Zhou

  4. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

    Yunpeng Cai

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© 2017 Springer International Publishing Switzerland

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Liao, Q., Bu, D., Sun, L., Luo, H., Zhao, Y. (2017). Identification and Functional Annotation of LncRNAs in Human Disease. In: Xu, D., Wang, M., Zhou, F., Cai, Y. (eds) Health Informatics Data Analysis. Health Information Science. Springer, Cham. https://doi.org/10.1007/978-3-319-44981-4_3

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  • DOI: https://doi.org/10.1007/978-3-319-44981-4_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-44979-1

  • Online ISBN: 978-3-319-44981-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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