Abstract
Color vision is the ability to perceive differences in the wavelength content of a light source, a process which starts with absorption of photons of different wavelengths and energies by the photopigments. In this chapter, the photopigments and the efficiency with which light of different wavelengths are absorbed by a photopigment are discussed. In addition, the translation of a photoisomerization to a photoreceptor excitation is considered as well as the signal transmission from the photoreceptors to post-receptoral cells and the post-receptoral processing of this signal in the retina. A large part of the chapter provides an overview of recent evidence that retinal processes in the major retino-geniculate pathways that are relevant for luminance and color vision, can be studied in the intact visual system by electroretinography (ERG), thus providing the possibility of direct study of human retinal physiology.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–3. doi:10.1126/science.1067262.
Hattar S, Liao HW, Takao M, Berson DM, Yau KW. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002;295(5557):1065–70. doi:10.1126/science.1069609.
Dacey DM, Liao HW, Peterson BB, Robinson FR, Smith VC, Pokorny J, et al. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature. 2005;433(7027):749–54. doi:10.1038/nature03387.
Brown TM, Gias C, Hatori M, Keding SR, Semo M, Coffey PJ, et al. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol. 2010;8(12):e1000558. doi:10.1371/journal.pbio.1000558.
Lall GS, Revell VL, Momiji H, Al Enezi J, Altimus CM, Guler AD, et al. Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. Neuron. 2010;66(3):417–28. doi:10.1016/j.neuron.2010.04.037.
Allen AE, Storchi R, Martial FP, Petersen RS, Montemurro MA, Brown TM, et al. Melanopsin-driven light adaptation in mouse vision. Curr Biol. 2014;24(21):2481–90. doi:10.1016/j.cub.2014.09.015.
Ecker JL, Dumitrescu ON, Wong KY, Alam NM, Chen SK, LeGates T, et al. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron. 2010;67(1):49–60. doi:10.1016/j.neuron.2010.05.023.
Naka KI, Rushton WA. S-potentials from colour units in the retina of fish (Cyprinidae). J Physiol (London). 1966;185:536–55.
Smith VC, Pokorny J. Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm. Vision Res. 1975;15:161–71.
DeMarco P, Pokorny J, Smith VC. Full-spectrum cone sensitivity functions for X-chromosome-linked anomalous trichromats. J Opt Soc Am A. 1992;9(9):1465–76.
Stockman A, MacLeod DIA, Johnson NE. Spectral sensitivities of the human cones. J Opt Soc Am A. 1993;10(12):2491–521.
Stockman A, Sharpe LT. Cone spectral sensitivities and color matching. In: Gegenfurtner K, Sharpe LT, editors. Color vision: from genes to perception. Cambridge: Cambridge University Press; 1999. p. 53–88.
Sharpe LT, Stockman A, Jägle H, Knau H, Klausen G, Reitner A, et al. Red, green and red-green hybrid pigments in the human retina: correlations between deduced protein sequences and psychophysically-measured spectral sensitivities. J Neurosci. 1998;18:10053–69.
Stockman A, Sharpe LT, Fach C. The spectral sensitivity of the human short-wavelength sensitive cones derived from thresholds and color matches. Vision Res. 1999;39(17):2901–27.
Wyszecki G, Stiles W. Color science: concepts and methods, quantitative data and formulas. New York: Wiley; 1982.
Stiles WS. Increment thresholds and the mechanisms of colour vision. Doc Ophthalmol. 1949;3:138–63.
Stiles WS. Color vision: the approach through increment threshold sensitivity. Proc Natl Acad Sci U S A. 1959;45:100–14.
Donner KO, Rushton WAH. Retinal stimulation by light substitution. J Physiol. 1959;149:288–302.
Estévez O, Spekreijse H. A spectral compensation method for determining the flicker characteristics of the human colour mechanisms. Vision Res. 1974;14:823–30.
Estévez O, Spekreijse H. The “silent substitution” method in visual research. Vision Res. 1982;22:681–91.
Kremers J. The assessment of L- and M-cone specific electroretinographical signals in the normal and abnormal retina. Prog Retin Eye Res. 2003;22:579–605.
Shapiro AG, Pokorny J, Smith VC. Cone-rod receptor spaces with illustrations that use the CRT phosphor and light-emitting-diode spectra. J Opt Soc Am A. 1996;13:2319–28.
Cao D, Nicandro N, Barrionuevo PA. A five-primary photostimulator suitable for studying intrinsically photosensitive retinal ganglion cell functions in humans. J Vis. 2015;15(1):15.1.27. doi:10.1167/15.1.27.
Huchzermeyer C, Schlomberg J, Welge-Lussen U, Berendschot TT, Pokorny J, Kremers J. Macular pigment optical density measured by heterochromatic modulation photometry. PLoS One. 2014;9(10):e110521. doi:10.1371/journal.pone.0110521.
Bone RA, Landrum JT, Cains A. Optical density spectra of the macular pigment in vivo and in vitro. Vision Res. 1992;32(1):105–10.
Kremers J, Usui T, Scholl HPN, Sharpe LT. Cone signal contributions to electroretinograms in dichromats and trichromats. Invest Ophthalmol Vis Sci. 1999;40:920–30.
Usui T, Kremers J, Sharpe LT, Zrenner E. Flicker cone electroretinogram in dichromats and trichromats. Vision Res. 1998;38(21):3391–6.
Kremers J, Stepien MW, Scholl HPN, Saito CA. Cone selective adaptation influences L- and M-cone driven signals in electroretinography and psychophysics. J Vis. 2003;3:146–60.
Kremers J, Parry NR, Panorgias A, Murray IJ. The influence of retinal illuminance on L- and M-cone driven electroretinograms. Vis Neurosci. 2011;28:129–35. doi:10.1017/S0952523810000556. S0952523810000556 [pii].
Park JC, Cao D, Collison FT, Fishman GA, McAnany JJ. Rod and cone contributions to the dark-adapted 15-Hz flicker electroretinogram. Doc Ophthalmol. 2015;130(2):111–9. doi:10.1007/s10633-015-9480-3.
Hecht S, Haig C, Chase AM. The influence of light adaptation on subsequent dark adaptation of the eye. J Gen Physiol. 1937;20(6):831–50.
Silveira LCL, Grünert U, Kremers J, Lee BB, Martin PR. Comparative anatomy and physiology of the primate retina. In: Kremers J, editor. The primate visual system; a comparative approach. Chichester: Wiley; 2005. p. 127–60.
Polyak SL. The retina. Chicago: University of Chicago Press; 1941.
Boycott BB, Dowling JE. Organization of the primate retina: light microscopy. Philos Trans R Soc Lond B. 1969;255:109–84.
Boycott BB, Wässle H. Morphological classification of bipolar cells of the primate retina. Eur J Neurosci. 1991;3:1069–88.
Silveira LC, Perry VH. The topography of magnocellular projecting ganglion cells (M-ganglion cells) in the primate retina. Neuroscience. 1991;40(1):217–37.
Röhrenbeck J, Wässle H, Boycott BB. Horizontal cells in the monkey retina: immunocytochemical staining with antibodies against calcium binding proteins. Eur J Neurosci. 1989;1:407–20.
Martin PR, Grünert U. Spatial density and immunoreactivity of bipolar cells in the macaque monkey retina. J Comp Neurol. 1992;323(2):269–87. doi:10.1002/cne.903230210.
Kouyama N, Marshak DW. Bipolar cells specific for blue cones in the macaque retina. J Neurosci. 1992;12:1233–52.
Grünert U, Greferath U, Boycott BB, Wässle H. Parasol (Pα) ganglion-cells of the primate fovea: immunocytochemical staining with antibodies against GABA A-receptors. Vision Res. 1993;33(1):1–14.
Wässle H, Grünert U, Martin PR, Boycott BB. Immunocytochemical characterization and spatial distribution of midget bipolar cells in the macaque monkey retina. Vision Res. 1994;34:561–79.
Watanabe M, Rodieck RW. Parasol and midget ganglion cells of the primate retina. J Comp Neurol. 1989;289:434–54.
Dacey DM, Petersen MR. Dendritic field size and morphology of midget and parasol ganglion cells of the human retina. Proc Natl Acad Sci U S A. 1992;89:9666–70.
Dacey DM, Lee BB. The ‘blue-on’ opponent pathway in primate retina originates from a distinct bistratified ganglion cell type. Nature. 1994;367:731–5.
Dacey DM, Lee BB, Stafford DM, Smith VC, Pokorny J. Horizontal cells of the primate retina: cone specificity without cone opponency. Science. 1996;271:656–8.
Dacey DM, Peterson BB, Robinson FR, Gamlin PD. Fireworks in the primate retina: in vitro photodynamics reveals diverse LGN-projecting ganglion cell types. Neuron. 2003;37(1):15–27.
Kolb H, Mariani A, Gallego A. A second type of horizontal cell in the monkey retina. J Comp Neurol. 1980;189:31–44.
Kolb H, Linberg K, Fisher SK. Neurons of the human retina: a Golgi study. J Comp Neurol. 1992;318:147–87.
Kolb H, Fernandez E, Schouten J, Ahnelt P, Linberg KA, Fisher SK. Are there three types of horizontal cell in the human retina? J Comp Neurol. 1994;343:370–86.
Ahnelt PK, Kolb H. Horizontal cells and cone photoreceptors in human retina: a Golgi-electron microscopic study of spectral connectivity. J Comp Neurol. 1994;343:406–27.
Boycott BB, Kolb H. The horizontal cells of the rhesus monkey retina. J Comp Neurol. 1973;148:91–114.
Boycott BB, Hopkins JM, Sperling HG. Cone connections of the horizontal cells of the rhesus monkey’s retina. Proc R Soc Lond B. 1987;229:345–79.
Ahnelt P, Kolb H. Horizontal cells and cone photoreceptors in primate retina: a Golgi-light microscopic study of spectral connectivity. J Comp Neurol. 1994;343(3):387–405. doi:10.1002/cne.903430305.
Goodchild AK, Chan TL, Grünert U. Horizontal cell connections with short-wavelength-sensitive cones in macaque monkey retina. Vis Neurosci. 1996;13:833–45.
dos Reis JW, de Carvalho WA, Saito CA, Silveira LC. Morphology of horizontal cells in the retina of the capuchin monkey, Cebus apella: how many horizontal cell classes are found in dichromatic primates? J Comp Neurol. 2002;443(2):105–23.
Dos Santos SN, Dos Reis JWL, da Silva-Filho M, Kremers J, Silveira LCL. Horizontal cell morphology in nocturnal and diurnal primates: a comparison between owl-monkey (Aotus) and capuchin monkey (Cebus). Vis Neurosci. 2005;22:405–15.
Peichl L. Morphology of interneurons: horizontal cells. In: Dartt DA, editor. Encyclopedia of the eye. Oxford: Academic; 2010. p. 74–82.
Dacheux RF, Raviola E. Horizontal cells in the retina of the rabbit. J Neurosci. 1982;2:1486–93.
Bloomfield SA, Miller RF. A physiological and morphological study of the horizontal cell types of the rabbit retina. J Comp Neurol. 1982;208:288–303.
Dorgau B, Herrling R, Schultz K, Greb H, Segelken J, Stroh S, et al. Connexin50 couples axon terminals of mouse horizontal cells by homotypic gap junctions. J Comp Neurol. 2015. doi:10.1002/cne.23779.
Thoreson WB, Mangel SC. Lateral interactions in the outer retina. Prog Retin Eye Res. 2012;31(5):407–41. doi:10.1016/j.preteyeres.2012.04.003.
Chan TL, Goodchild AK, Martin PR. The morphology and distribution of horizontal cells in the retina of a New World monkey, the marmoset Callithrix jacchus: a comparison with macaque monkey. Vis Neurosci. 1997;14:125–40.
Chan TL, Grunert U. Horizontal cell connections with short wavelength-sensitive cones in the retina: a comparison between New World and Old World primates. J Comp Neurol. 1998;393(2):196–209.
Svaetichin G, MacNichol EF. Retinal mechanisms for chromatic and achromatic vision. Ann N Y Acad Sci. 1958;74:385–404.
Ammermüller J, Kolb H. Functional architecture of the turtle retina. Prog Retin Eye Res. 1996;15:393–433.
Kolb H, Boycott BB, Dowling JE. A second type of midget bipolar cell in the primate retina. Philos Trans R Soc Lond B. 1969;255:177–80.
Kolb H. Organization of the outer plexiform layer of the primate retina: electron microscopy of Golgi-impregnated cells. Philos Trans R Soc Lond B. 1970;258:261–83.
Mariani AP. Giant bistratified bipolar cells in monkey retina. Anat Rec. 1983;206:215–20.
Mariani AP. Bipolar cells in monkey retina selective for the cone likely to be blue-sensitive. Nature. 1984;308:184–6.
Chan TL, Martin PR, Clunas N, Grunert U. Bipolar cell diversity in the primate retina: morphologic and immunocytochemical analysis of a new world monkey, the marmoset Callithrix jacchus. J Comp Neurol. 2001;437(2):219–39.
Grünert U, Martin PR, Wassle H. Immunocytochemical analysis of bipolar cells in the macaque monkey retina. J Comp Neurol. 1994;348(4):607–27. doi:10.1002/cne.903480410.
Weltzien F, Percival KA, Martin PR, Grünert U. Analysis of bipolar and amacrine populations in marmoset retina. J Comp Neurol. 2015;523(2):313–34. doi:10.1002/cne.23683.
Chan TL, Martin PR, Grunert U. Immunocytochemical identification and analysis of the diffuse bipolar cell type DB6 in macaque monkey retina. Eur J Neurosci. 2001;13(4):829–32.
Silveira LCL, Lee BB, Yamada ES, Kremers J, Hunt DM. Post-receptoral mechanisms of colour vision in new world primates. Vision Res. 1998;38(21):3329–37.
Lameirao SV, Hamassaki DE, Rodrigues AR, DE Lima SM, Finlay BL, Silveira LC. Rod bipolar cells in the retina of the capuchin monkey (Cebus apella): characterization and distribution. Vis Neurosci. 2009;26(4):389–96. doi:10.1017/S0952523809990186.
Martin PR, Lee BB, White AJ, Solomon SG, Ruttiger L. Chromatic sensitivity of ganglion cells in the peripheral primate retina. Nature. 2001;410(6831):933–6. doi:10.1038/35073587.
Rodieck RW. The primate retina. Comparative primate biology. Neuroscience. 1988;4:203–78.
Joo HR, Peterson BB, Haun TJ, Dacey DM. Characterization of a novel large-field cone bipolar cell type in the primate retina: evidence for selective cone connections. Vis Neurosci. 2011;28(1):29–37. doi:10.1017/S0952523810000374.
Haverkamp S, Grünert U, Wassle H. The cone pedicle, a complex synapse in the retina. Neuron. 2000;27(1):85–95.
Puthussery T, Venkataramani S, Gayet-Primo J, Smith RG, Taylor WR. NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. J Neurosci. 2013;33(41):16045–59. doi:10.1523/JNEUROSCI.1249-13.2013.
Puthussery T, Percival KA, Venkataramani S, Gayet-Primo J, Grünert U, Taylor WR. Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina. J Neurosci. 2014;34(22):7611–21. doi:10.1523/JNEUROSCI.4855-13.2014.
Puthussery T, Gayet-Primo J, Taylor WR, Haverkamp S. Immunohistochemical identification and synaptic inputs to the diffuse bipolar cell type DB1 in macaque retina. J Comp Neurol. 2011;519(18):3640–56. doi:10.1002/cne.22756.
Lee SC, Jusuf PR, Grunert U. S-cone connections of the diffuse bipolar cell type DB6 in macaque monkey retina. J Comp Neurol. 2004;474(3):353–63. doi:10.1002/cne.20139.
Lee SC, Grünert U. Connections of diffuse bipolar cells in primate retina are biased against S-cones. J Comp Neurol. 2007;502(1):126–40. doi:10.1002/cne.21284.
Hartline HK. The response of single optic nerve fibers of the vertebrate eye to illumination of the retina. Am J Physiol. 1938;121:400–15.
Kuffler SW. Discharge patterns and functional organization of mammalian retina. J Neurophysiol. 1953;16:37–68.
Nakanishi S. Second-order neurones and receptor mechanisms in visual- and olfactory-information processing. Trends Neurosci. 1995;18(8):359–64.
Slaughter MM, Miller RF. An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons. Science. 1983;219(4589):1230–2.
Slaughter MM, Miller RF. 2-Amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science. 1981;211(4478):182–5.
Lee BB, Martin PR, Valberg A. The physiological basis of heterochromatic flicker photometry demonstrated in the ganglion cells of the macaque retina. J Physiol. 1988;404:323–47.
Kaiser PK, Lee BB, Martin PR, Valberg A. The physiological basis of the minimally distinct border demonstrated in the ganglion cells of the macaque retina. J Physiol. 1990;422:153–83.
Kremers J, Lee BB, Kaiser PK. Sensitivity of macaque retinal ganglion cells and human observers to combined luminance and chromatic modulation. J Opt Soc Am A. 1992;9:1477–85.
Maunsell JHR, Nealey TA, DePriest DD. Magnocellular and parvocellular contributions to responses in the middle temporal visual area (MT) of the macaque monkey. J Neurosci. 1990;10(10):3323–34.
Lee BB, Wehrhahn C, Westheimer G, Kremers J. Macaque ganglion cell responses to stimuli that elicit hyperacuity in man: detection of small displacements. J Neurosci. 1993;13(3):1001–9.
Lee BB, Wehrhahn C, Westheimer G, Kremers J. The spatial precision of macaque ganglion cell responses in relation to Vernier acuity of human observers. Vision Res. 1995;35(19):2743–58.
Ruttiger L, Lee B, Sun H. Transient cells can be neurometrically sustained: the positional accuracy or retinal signals to moving targets. J Vis. 2002;2(3):232–42. doi:10.1167/2.3.3.
Lee BB, Martin PR, Valberg A, Kremers J. Physiological mechanisms underlying psychophysical sensitivity to combined luminance and chromatic modulation. J Opt Soc Am A. 1993;10:1403–12.
Lee BB, Kremers J, Yeh T. Receptive fields of primate retinal cells studied with a novel technique. Vis Neurosci. 1998;15:161–75.
Martin PR, Blessing EM, Buzas P, Szmajda BA, Forte JD. Transmission of colour and acuity signals by parvocellular cells in marmoset monkeys. J Physiol. 2011;589(Pt 11):2795–812. doi:10.1113/jphysiol.2010.194076.
Livingstone MS, Hubel DH. Psychophysical evidence for separate channels for the perception of form, color, movement, and depth. J Neurosci. 1987;7(11):3416–68.
Livingstone MS, Hubel DH. Segregation of form, color, movement, and depth: anatomy, physiology, and perception. Science. 1988;240:740–9.
Martin PR. Colour processing in the primate retina: recent progress. J Phsyiol (London). 1998;513(3):631–8.
Wiesel TN, Hubel DH. Spatial and chromatic interactions in the lateral geniculate body of the rhesus monkey. J Neurophysiol. 1966;29:1115–56.
McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, et al. ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol. 2015;130(1):1–12. doi:10.1007/s10633-014-9473-7.
Frishman LJ. Origins of the electroretinogram. In: Heckenlively JR, Arden GB, editors. Principles and practice of clinical electrophysiology of vision. Cambridge, London: The MIT Press; 2006. p. 139–83.
Sustar M, Hawlina M, Brecelj J. ON- and OFF-response of the photopic electroretinogram in relation to stimulus characteristics. Doc Ophthalmol. 2006;113:43–52.
Pangeni G, Lammer R, Tornow RP, Horn FK, Kremers J. On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients. Doc Ophthalmol. 2012. doi:10.1007/s10633-012-9323-4.
Viswanathan S, Frishman LJ, Robson JG. The uniform field and pattern ERG in macaques with experimental glaucoma: removal of spiking activity. Invest Ophthalmol Vis Sci. 2000;41(9):2797–810.
Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith Iii EL. The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40(6):1124–36.
Viswanathan S, Frishman LJ, Robson JG, Walters JW. The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci. 2001;42(2):514–22.
Armington JC. The electroretinogram. New York: Academic; 1974.
Jacobs GH. The discovery of spectral opponency in visual systems and its impact on understanding the neurobiology of color vision. J Hist Neurosci. 2014;23(3):287–314. doi:10.1080/0964704X.2014.896662.
Riggs LA, Johnson EP, Schick AM. Electrical responses of the human eye to changes in wavelength of the stimulating light. J Opt Soc Am. 1966;56:1621–7.
Riggs LA, Sternheim CE. Human retinal and occipital potentials evoked by changes of the wavelength of the stimulating light. J Opt Soc Am. 1969;59(5):635–40.
Sperling HG, Harwerth RS. Red-green cone interaction in the increment-threshold spectral sensitivity of primates. Science. 1971;172:180–4.
Harwerth RS, Sperling HG. Effects of intense visible radiation on the increment-threshold spectral sensitivity of the rhesus monkey eye. Vision Res. 1975;15:1193–204.
Mills SL, Sperling HG. Red/green opponency in the rhesus macaque ERG spectral sensitivity is reduced by bicuculline. Vis Neurosci. 1990;5:217–21.
Sperling HG, Mills SL. Red-green interactions in the spectral sensitivity of primates as derived from ERG and behavioral data. Vis Neurosci. 1991;7:75–86.
van Norren D, Baron WS. Increment spectral sensitivities of the primate late receptor potential and b-wave. Vision Res. 1977;17(7):807–10.
King-Smith PE, Carden D. Luminance and opponent-color contributions to visual detection and adaptation and to temporal and spatial integration. J Opt Soc Am. 1976;66:709–17.
Bush RA, Sieving PA. Inner retinal contributions to the primate photopic fast flicker electroretinogram. J Opt Soc Am A. 1996;13(3):557–65.
Armington JC. Chromatic and short term dark adaptation of the human electroretinogram. J Opt Soc Am. 1959;49:1169–75.
DeValois RL, Abramov I, Jacobs GH. Analysis of response patterns of LGN cells. J Opt Soc Am. 1966;56:966–77.
Baron WS. Cone difference signal in foveal local electroretinogram of primate. Invest Ophthalmol Vis Sci. 1980;19(12):1442–8.
Donovan WJ, Baron WS. Identification of the R-G-cone difference signal in the corneal electroretinogram of the primate. J Opt Soc Am A. 1982;72(8):1014–20.
Jacobs GH. Primate photopigments and primate color vision. Proc Natl Acad Sci U S A. 1996;93:577–81.
Jacobs GH, Deegan Ii JF. Spectral sensitivity of macaque monkeys measured with ERG flicker photometry. Vis Neurosci. 1997;14:921–8.
Jacobs GH, Deegan IJS, Moran JL. ERG measurements of the spectral sensitivity of common chimpanzee (Pan troglodytes). Vision Res. 1996;36(16):2587–94.
Jacobs GH, Neitz J. Electrophysiological estimates of individual variation in the L/M cone ratio. In: Drum B, editor. Colour vision deficiencies XI. Dordretch: Kluwer; 1993. p. 107–12.
Jacobs GH, Neitz J, Krogh K. Electroretinogram flicker photometry and its applications. J Opt Soc Am A. 1996;13(3):641–8.
Neitz J, Jacobs GH. Electroretinogram measurements of cone spectral sensitivity in dichromatic monkeys. J Opt Soc Am A. 1984;1:1175–80.
Kremers J, Scholl HPN, Knau H, Berendschot TTJM, Usui T, Sharpe LT. L/M cone ratios in human trichromats assesed by psychophysics, electroretinograpy, and retinal densitometry. J Opt Soc Am. 2000;17:517–26.
Brainard DH, Roorda A, Yamauchi Y, Calderone JB, Metha AB, Neitz M, et al. Functional consequences of the relative numbers of L and M cones. J Opt Soc Am A. 2000;17(3):607–14.
Hofer H, Carroll J, Neitz J, Neitz M, Williams DR. Organization of the human trichromatic cone mosaic. J Neurosci. 2005;25(42):9669–79.
Hagstrom SA, Neitz J, Neitz M. Ratio of M/L pigment gene expression decreases with retinal eccentricity. In: Cavonius CR, editor. Colour vision deficiencies XIII. Dordrecht: Kluwer; 1997. p. 59–65.
Hagstrom SA, Neitz J, Neitz M. Variation in cone populations for red-green color vision examined by analysis of mRNA. Neuroreport. 1998;9:1963–7.
Hagstrom SA, Neitz M, Neitz J. Cone pigment gene expression in individual photoreceptors and the chromatic topography of the retina. J Opt Soc Am A Opt Image Sci Vis. 2000;17(3):527–37.
Kuchenbecker JA, Sahay M, Tait DM, Neitz M, Neitz J. Topography of the long- to middle-wavelength sensitive cone ratio in the human retina assessed with a wide-field color multifocal electroretinogram. Vis Neurosci. 2008;25(3):301–6.
Jacob MM, Pangeni G, Gomes BD, Souza GS, Da Silva Filho M, Silveira LCL, et al. The spatial properties of L- and M-cone inputs to electroretinograms that reflect different types of post-receptoral processing. PLoS One. 2015;10(3):e0121218. doi:10.1371/journal.pone.0121218.
de Lange H. Research into the dynamic nature of the human fovea-cortex systems with intermittent and modulated light. I. Attenuation characteristics with white and colored light. J Opt Soc Am. 1958;48:777–84.
Kelly DH, Norren DV. Two-band model of heterochromatic flicker. J Opt Soc Am. 1977;67:1081–91.
Kremers J, Link B. Electroretinographic responses that may reflect activity of parvo- and magnocellular post-receptoral visual pathways. J Vis. 2008;8(15/11):1–14.
Kremers J, Pangeni G. Electroretinographic responses to photoreceptor specific sine wave modulation. J Opt Soc Am A. 2012;29(2):A309–16.
Kommanapalli D, Murray IJ, Kremers J, Parry NR, McKeefry DJ. Temporal characteristics of L- and M-cone isolating steady-state electroretinograms. J Opt Soc Am A Opt Image Sci Vis. 2014;31(4):A113–20. doi:10.1364/JOSAA.31.00A113.
Kremers J, Rodrigues AR, Silveira LCL, da Silva-Filho M. Flicker ERGs representing chromaticity and luminance signals. Invest Ophthalmol Vis Sci. 2010;51:577–87.
Lee BB, Sun H, Valberg A. Segregation of chromatic and luminance signals using a novel grating stimulus. J Physiol. 2011;589(Pt 1):59–73. doi:10.1113/jphysiol.2010.188862. jphysiol.2010.188862 [pii].
Parry NR, Murray IJ, Panorgias A, McKeefry DJ, Lee BB, Kremers J. Simultaneous chromatic and luminance human electroretinogram responses. J Physiol. 2012;590:3141–54. doi:10.1113/jphysiol.2011.226951.
Kremers J, Pangeni G, Tsaousis KT, McKeefry D, Murray IJ, Parry NR. Incremental and decremental L- and M-cone driven ERG responses: II. Sawtooth stimulation. J Opt Soc Am A Opt Image Sci Vis. 2014;31(4):A170–8. doi:10.1364/JOSAA.31.00A170.
McKeefry D, Kremers J, Kommanapalli D, Challa NK, Murray IJ, Maguire J, et al. Incremental and decremental L- and M-cone-driven ERG responses: I. Square-wave pulse stimulation. J Opt Soc Am A Opt Image Sci Vis. 2014;31(4):A159–69. doi:10.1364/JOSAA.31.00A159.
Murray IJ, Kremers J, Parry NRA. L- and M-Cone isolating ergs: LED versus CRT stimulation. Vis Neurosci. 2008;25:327–31.
Yamaguchi S, Motulsky AG, Deeb SS. Visual pigment gene structure and expression in human retinae. Hum Mol Genet. 1997;6:981–90.
Acknowledgements
Luiz Carlos da Silva Silveira passed away on 10th July 2016. This work was supported by German Research Council (DFG) grants KR 1317/9-1, KR1317/9-2 and KR1317/13-1.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Kremers, J., Silveira, L.C.L., Parry, N.R.A., McKeefry, D.J. (2016). The Retinal Processing of Photoreceptor Signals. In: Kremers, J., Baraas, R., Marshall, N. (eds) Human Color Vision. Springer Series in Vision Research, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-44978-4_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-44978-4_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-44976-0
Online ISBN: 978-3-319-44978-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)