Abstract
Osseointegration of dental implants requires sufficient intrabony blood supply. In extremely resorbed areas, however, the main source of blood is the periosteal arteries. Basal implant placement in severely atrophic jaws is thus especially challenging because of the poor quality as well as the reduced volume of the future recipient bone site. This situation is aggravated in smokers. Calvaria or iliac bone grafts, mental nerve displacement, and sinus lift procedures are often performed prior to implant placement to overcome the initially unfavorable biological, anatomical, and mechanical status. Patients are often reluctant to undergo such procedures, though, as they are time-consuming and expensive and involve unpredictable degrees of morbidity at the donor and/or recipient sites. Although free bone grafts (autologous bone or bone substitutes) can augment bone volume, they do not promote better blood supply per se; only vascularized pedicular bone grafts are capable of this. Furthermore, in some instances, postsurgical scar tissue actually reduces the blood supply. Stem cell activation using osseotensors and use of PRF membranes are two of the approaches developed to overcome these difficulties.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Change history
16 October 2019
The original version of this book was revised to include the “Conflict of interest statement” in all chapters. The erratum to this book can be found at https://doi.org/10.1007/978-3-319-44873-2_16
Recommended Reading
Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2001;1(42):55–62.
Mosesson MW, Siebenlist KR, Meh DA. The structure and biological features of fibrinogen and fibrin. Ann N Y Acad Sci. 2001;936:11–30.
Weibrich G, Kleis WK, Kunz-Kostomanolakis M, Loos AH, Wagner W. Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor. Int J Oral Maxillofac Implants. 2001;16:693–9.
Weibrich G, Kleis WK, Hafner G, Hitzler WE, Wagner W. Comparison of platelet, leukocyte, and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified Curasan kit, with preparations received from a local blood bank. Clin Oral Implants Res. 2003;14:357–62.
Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized platelet rich fibrin with the low speed concept: growth factor release, biocompatibility and cellular response. J Periodontol. 2016;2:1–17.
Shamloo A, Xu H, Heilshorn S. Mechanisms of vascular endothelial growth factor-induced pathfinding by endothelial sprouts in biomaterials. Tissue Eng Part A. 2012;18(3–4):320–30.
Maciel J, Oliveira MI, Colton E, McNally AK, Oliveira C, Anderson JM, Barbosa MA. Adsorbed fibrinogen enhances production of bone- and angiogenic-related factors by monocytes/macrophages. Tissue Eng Part A. 2014;20(1–2):250–63.
Kawazoe T, Kim HH. Tissue augmentation by white blood cell-containing platelet-rich plasma. Cell Transplant. 2012;21(2–3):601–7.
Soltan M, Rohrer MD, Prasad HS. Monocytes: super cells for bone regeneration. Implant Dent. 2012;21(1):13–20.
Pirraco RP, Reis RL, Marques AP. Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs. J Tissue Eng Regen Med. 2013;7(5):392–400.
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick C, Choukroun J. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40(6):679–89.
Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-rich fibrin and soft tissue wound healing: a systematic review. Tissue Eng Part B Rev. 2016;23(1):83–99.
Alikhani M. Accelerated orthodontics. Integrating a new concept in your daily practice. Presented at: XXXI World ICOI Congress; the Future of Implant Dentistry; October 3–5, 2014, Tokyo, Japan; 2014.
Barone A, Nannmark U. Bone biomaterials & beyond. Milano: Edra Milano; 2014.
Binderman I, Zor U, Kaye AM, et al. The transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipidase A2. Calcif Tissue Int. 1988;42:261–6.
Bonewald F. The amazing osteocyte. J Bone Miner Res. 2011;26(2):229–38.
Bouletreau PJ, Warren SM, Spector JA, Peled ZM, Gerrets RP, Greenwald JA, Longaker MT. Hypoxia and VEGF up-regulate BMP2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing. Plast Reconstr Surg. 2002;109:2384–97.
Chappard D. Les cellules osseuses, le modelage et le remodelage osseux. In: Guillaume B, Audran M, Chappard D, editors. Tissue osseux et biomatériaux en chirurgie dentaire, vol. 2. Paris: Quintesssence International; 2014. p. 21–41.
Chenyu H, Ogawa R. Mechanotransduction in bone repair and regeneration. FASEB J. 2010;24(10):3625–32.
Dolan EB, Vaughan TJ, Nieburg GL, Casey C, Tallon D, McNamara LM. How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigation. J Biomech Eng. 2014;136:021019.
Dolan EB, Haugh MG, Voisin MC, Tallon D, McNamara LM. Thermally induced osteocyte damage initiates a remodelling signalling cascade. PLoS One. 2015;10:e0119652.
Eghbali-Fatourechi GZ, Lamsam J, Fraser D, Nagel D, Riggs BL, Sundeep K, Khosla S. Circulating osteoblast-lineage cells in humans. N Engl J Med. 2005;352:1959–66.
Ekström K, Omar O, Granéli C, Wang X, Vazirisani F, Thomsen P. Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. PLoS One. 2013;8(9):e75227. https://doi.org/10.1371/journal.pone.0075227.
Frost MH. The biology of fracture healing. An overview for clinicians. Part II. Clin Orthop Relat Res. 1989;248:294–309.
Huang C, Ogaxa R. Mechanotransduction in bone repair and regeneration. FASEB J. 2010;24:3625–32.
Ilizarov GA. The principles of the Ilizarov method. Bull Hosp Joint Dis Orthop Inst. 1988;48:1–11.
Ilizarov GA. The tension stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clin Orthop Relat Res. 1989a;238:249–81.
Ilizarov GA. The tension stress effect on the genesis and growth of tissues. Part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res. 1989b;239:263–85.
Ilizarov GA. Clinical application of the tension stress effect for limb lengthening. Clin Orthop Relat Res. 1990;250:8–26.
Ingber DE. Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol. 1997;59:575–99.
Ingber DE. Mechanobiology and diseases of mechanotransduction. Ann Med. 2003;35:564–77.
Kazanjian VH. The interrelation of dentistry and surgery in the treatment of deformities of the face and jaws. Am J Orthod Oral Surg. 1941;27:10–30.
Kuroda R, Matsumoto T, Kawakami Y, Fukui T, Mifune Y, M Kurosaka M. Clinical impact of circulating CD34-positive cells on bone regeneration and healing. Tissue Eng Part B Rev. 2014;20(3):190–9. https://doi.org/10.1089/ten.TEB.2013.0511.
Marx JL. Angiogenesis research comes of age. Science. 1987;237:23–4.
Matsumoto T, Kawamoto A, Kuroda R, Ishikawa M, Mifune Y, Iwasaki H, Miwa M, Horii M, Hayashi S, Oyamada A, Nishimura H, Murasawa S, Doita M, Kurosaka M, Asahara T. Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol. 2006;169(4):1440–57.
McNulty MA, Virdi AS, Christopherson KW, Sena K, Frank RR, Sumner DR. Adult stem cell mobilization enhances intramembranous bone regeneration: a pilot study. Clin Orthop Relat Res. 2012;470(9):2503–12.
Misch CE. Contemporary implant dentistry. St Louis, MO: Mosby Elsevier; 2008. p. 1034–5.
Misch CE, Qu Z, Bidez MW. Mechanical properties of trabecular bone in the human mandible. Implications of dental implant planning and surgical placement. J Oral Maxillofac Surg. 1999;57:700–6.
Morgan EF, Gleason RE, Hayward LNM, Leong PL, Palomares KTS. Mechanotransduction and fracture repair. J Bone Joint Surg Am. 2008;90(Suppl 1):25–30.
Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008;118(2):491–504.
Odin G, Misch CE, Binderman I, et al. Fixed rehabilitation of severely atrophic jaws using immediately loaded basal disk implants after in situ bone activation. J Oral Implantol. 2012;38:611–6.
Odin G, Petitbois R, Cotten P, Philip P. Distraction osteogenesis using bone matrix osteotensors in ectodermal dysplasia: a case report. Implant Dent. 2015;24(5):612–9.
Scortecci G. Activation of osteogenesis via bone matrix osteotensors prior to implant placement and/or bone grafting procedures. Nine years of clinical follow-up and research. Presented at XXXI ICOI World Congress; The Future of Implant Dentistry; October 3–5, 2014, Tokyo, Japan; 2014.
Scortecci G, Misch CE, Benner KU. Implants and restorative dentistry. London: Martin Dunitz; 2000. p. 79–85.
Sundelacruz S, Levin M, Kaplan DL. Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS One. 2008;3(11):e3737. https://doi.org/10.1371/journal.pone.0003737.
Sundelacruz S, Levin M, Kaplan DL. Comparison of the depolarization response of human mesenchymal stem cells from different donors. Sci Rep. 2015;5:18279. https://doi.org/10.1038/srep18279.
Suya H. Corticotomy in orthodontics. In: Hosl E, Baldauf A, editors. Mechanical and biological basics in orthodontic therapy. Heidelberg: Hütlig Buch; 1991. p. 207–26.
Urist MR. Bone formation by auto-induction. Science. 1965;150:893–9.
Vermeulen J. Euro Implanto lecture. France: Nice; 2012.
Zaidi N, Nixon AJ. Stem cell therapy in bone repair and regeneration. Ann N Y Acad Sci. 2007;1117:62–72.
Zhang W, Zhu C, Wu Y, Ye D, Wang S, Zou D, Zhang X, Kaplan DL, Jiang X. VEGF and BMP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation. Eur Cell Mater. 2014;27:1–11.
Conflict of interest statement
Gérard M. Scortecci is the inventor of the Diskimplant and holder of several associated patents that are exploited by the Victory company. He is an unpaid consultant to this firm and a minority shareholder in the company. No money was received from any of the companies mentioned in the book or from any of the companies whose products are mentioned.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Binderman, I., Scortecci, G.M., Philip, P., Choukroun, J., Aalam, AA. (2019). Initial Bone Bed Activation: Bone Matrix Osseotensors—Tissue Engineering. In: Scortecci, G. (eds) Basal Implantology. Springer, Cham. https://doi.org/10.1007/978-3-319-44873-2_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-44873-2_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-44871-8
Online ISBN: 978-3-319-44873-2
eBook Packages: MedicineMedicine (R0)