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Granulomatous Eruptions

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Pediatric Dermatopathology

Abstract

Granulomatous eruptions can be idiopathic, be seen in the setting of systemic disease or be an inflammatory response to an exogenous insult. Histologically, these dermatoses are defined by the presence of histiocytes within the dermis. Induration is frequently demonstrated on clinical exam. .

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References

  1. Short JH, Sulit DJ. Sea urchin spines in the stratum corneum: an early finding related to trauma. J Cutan Pathol. 2013;41(3):322–5.

    Article  PubMed  Google Scholar 

  2. Arzt L. Foreign body granulomas and Boeck’s sarcoid1. J Invest Dermatol. 1955;24(3):155–66.

    Article  CAS  PubMed  Google Scholar 

  3. Blessing K. Cutaneous granulomatous inflammation. Curr Diagn Pathol. 2005;11(4):219–35.

    Article  Google Scholar 

  4. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992;356(6370):604–7.

    Article  CAS  PubMed  Google Scholar 

  5. Joseph AL, Boros DL. Tumor necrosis factor plays a role in Schistosoma mansoni egg-induced granulomatous inflammation. J Immunol. 1993;151(10):5461–71.

    CAS  PubMed  Google Scholar 

  6. Lukacs NW, Chensue SW, Strieter RM, Warmington K, Kunkel SL. Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1. J Immunol. 1994;152(12):5883–9.

    CAS  PubMed  Google Scholar 

  7. De Zeeuw R, Van Praag MC, Oranje AP. Granuloma gluteale infantum: a case report. Pediatr Dermatol. 2000;17(2):141–3.

    Article  PubMed  Google Scholar 

  8. Bluestein J, Furner BB, Phillips D. Granuloma gluteale infantum: case report and review of the literature. Pediatr Dermatol. 1990;7(3):196–8.

    Article  CAS  PubMed  Google Scholar 

  9. Al-Faraidy NA, Al-Natour SH. A forgotten complication of diaper dermatitis: Granuloma gluteale infantum. J Family Community Med. 2011;17(2):107–9.

    Google Scholar 

  10. Konya J, Gow E. Granuloma gluteale infantum. Australas J Dermatol. 1996;37(1):57–8.

    Article  CAS  PubMed  Google Scholar 

  11. Lindsley CB, Petty RE. Overview and report on international registry of sarcoid arthritis in childhood. Curr Rheumatol Rep. 2000;2(4):343–8.

    Article  CAS  PubMed  Google Scholar 

  12. English 3rd JC, Patel PJ, Greer KE. Sarcoidosis. J Am Acad Dermatol. 2001;44(5):725–43. quiz 744–6.

    Article  PubMed  Google Scholar 

  13. Mana J, Marcoval J, Graells J, Salazar A, Peyri J, Pujol R. Cutaneous involvement in sarcoidosis. Relationship to systemic disease. Arch Dermatol. 1997;133(7):882–8.

    Article  CAS  PubMed  Google Scholar 

  14. Alexis JB. Sarcoidosis presenting as cutaneous hypopigmentation with repeatedly negative skin biopsies. Int J Dermatol. 1994;33(1):44–5.

    Article  CAS  PubMed  Google Scholar 

  15. Cather JC, Cohen PR. Ichthyosiform sarcoidosis. J Am Acad Dermatol. 1999;40(5 Pt 2):862–5.

    CAS  PubMed  Google Scholar 

  16. Manz LA, Rodman OG. Reappearance of quiescent scars. Sarcoidosis. Arch Dermatol. 1993;129(1):105. 108.

    Article  CAS  PubMed  Google Scholar 

  17. Ball NJ, Kho GT, Martinka M. The histologic spectrum of cutaneous sarcoidosis: a study of twenty-eight cases. J Cutan Pathol. 2004;31(2):160–8.

    Article  PubMed  Google Scholar 

  18. Kwon EJ, Hivnor CM, Yan AC, Forbes B, Elenitsas R, Albert D, Pawel B, Honig P, Pessler F. Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis. Pediatr Dermatol. 2007;24(5):517–24.

    Article  PubMed  Google Scholar 

  19. Mangas C, Fernández-Figueras M-T, Fité E, Fernández-Chico N, Sàbat M, Ferrándiz C. Clinical spectrum and histological analysis of 32 cases of specific cutaneous sarcoidosis. J Cutan Pathol. 2006;33(12):772–7.

    Article  PubMed  Google Scholar 

  20. Yanardağ H, Pamuk ÖN, Karayel T. Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med. 2003;97(8):978–82.

    Article  PubMed  Google Scholar 

  21. Jacyk WK. Cutaneous sarcoidosis in black South Africans. Int J Dermatol. 1999;38(11):841–5.

    Article  CAS  PubMed  Google Scholar 

  22. Design of a case control etiologic study of sarcoidosis (ACCESS). ACCESS Research Group. J Clin Epidemiol. 1999;52(12):1173–86.

    Google Scholar 

  23. Ali MM, Atwan AA, Gonzalez ML. Cutaneous sarcoidosis: updates in the pathogenesis. J Eur Acad Dermatol Venereol. 2009;24(7):747–55.

    Article  PubMed  CAS  Google Scholar 

  24. Smith G, Brownell I, Sanchez M, Prystowsky S. Advances in the genetics of sarcoidosis. Clin Genet. 2008;73(5):401–12.

    Article  CAS  PubMed  Google Scholar 

  25. Sverrild A, Backer V, Kyvik KO, Kaprio J, Milman N, Svendsen CB, Thomsen SF. Heredity in sarcoidosis: a registry-based twin study. Thorax. 2008;63(10):894–6.

    Article  CAS  PubMed  Google Scholar 

  26. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160(2):736–55.

    Google Scholar 

  27. Rossman MD, Thompson B, Frederick M, Maliarik M, Iannuzzi MC, Rybicki BA, Pandey JP, Newman LS, Magira E, Beznik-Cizman B, Monos D. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Am J Hum Genet. 2003;73(4):720–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Rybicki BA, Maliarik MJ, Poisson LM, Sheffer R, Chen KM, Major M, Chase GA, Iannuzzi MC. The major histocompatibility complex gene region and sarcoidosis susceptibility in African Americans. Am J Respir Crit Care Med. 2003;167(3):444–9.

    Article  PubMed  Google Scholar 

  29. Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schurmann M, Muller-Quernheim J, Krawczak M, Rosenstiel P, Schreiber S. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 2008;40(9):1103–6.

    Article  CAS  PubMed  Google Scholar 

  30. Li Y, Pabst S, Kubisch C, Grohe C, Wollnik B. First independent replication study confirms the strong genetic association of ANXA11 with sarcoidosis. Thorax. 2010;65(10):939–40.

    Article  PubMed  Google Scholar 

  31. Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, McKeigue P, Fischer A, Nebel A, Rybicki BA. Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans. Genes Immun. 2012;14(1):13–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Spagnolo P, Grunewald J. Recent advances in the genetics of sarcoidosis. J Med Genet. 2013;50(5):290–7.

    Article  CAS  PubMed  Google Scholar 

  33. Moss SE, Morgan RO. The annexins. Genome Biol. 2004;5(4):219.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet. 2005;37(4):357–64.

    Article  CAS  PubMed  Google Scholar 

  35. Brownell I, Ramirez-Valle F, Sanchez M, Prystowsky S. Evidence for mycobacteria in sarcoidosis. Am J Respir Cell Mol Biol. 2011;45(5):899–905.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Chen ES, Moller DR. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365–77. vii.

    Article  CAS  PubMed  Google Scholar 

  37. Barnard J, Rose C, Newman L, Canner M, Martyny J, McCammon C, Bresnitz E, Rossman M, Thompson B, Rybicki B, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Teirstein AS, Yeager Jr H, Johns CJ, Rabin DL, Cherniack R. Job and industry classifications associated with sarcoidosis in A Case-Control Etiologic Study of Sarcoidosis (ACCESS). J Occup Environ Med. 2005;47(3):226–34.

    Article  PubMed  Google Scholar 

  38. Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M, Terrin ML, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Thompson BW, Teirstein AS, Yeager Jr H, Johns CJ, Rabin DL, Rybicki BA, Cherniack R. A case control etiologic study of sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med. 2004;170(12):1324–30.

    Article  PubMed  Google Scholar 

  39. Izbicki G, Chavko R, Banauch GI, Weiden MD, Berger KI, Aldrich TK, Hall C, Kelly KJ, Prezant DJ. World Trade Center “sarcoid-like” granulomatous pulmonary disease in New York City Fire Department rescue workers. Chest. 2007;131(5):1414–23.

    Article  PubMed  Google Scholar 

  40. Chen ES, Moller DR. Etiologic role of infectious agents. Semin Respir Crit Care Med. 2014;35(3):285–95.

    Article  PubMed  Google Scholar 

  41. Antoniou KM, Tzouvelekis A, Alexandrakis MG, Tsiligianni I, Tzanakis N, Sfiridaki K, Rachiotis G, Bouros D, Siafakas NM. Upregulation of Th1 cytokine profile (IL-12, IL-18) in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis. J Interferon Cytokine Res. 2006;26(6):400–5.

    Article  CAS  PubMed  Google Scholar 

  42. Grunewald J, Eklund A. Role of CD4+ T cells in sarcoidosis. Proc Am Thorac Soc. 2007;4(5):461–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Moller DR, Forman JD, Liu MC, Noble PW, Greenlee BM, Vyas P, Holden DA, Forrester JM, Lazarus A, Wysocka M, Trinchieri G, Karp C. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol. 1996;156(12):4952–60.

    CAS  PubMed  Google Scholar 

  44. Muhlbauer JE. Granuloma annulare. J Am Acad Dermatol. 1980;3(3):217–30.

    Article  CAS  PubMed  Google Scholar 

  45. Cronquist SD, Stashower ME, Benson PM. Deep dermal granuloma annulare presenting as an eyelid tumor in a child, with review of pediatric eyelid lesions. Pediatr Dermatol. 1999;16(5):377–80.

    Article  CAS  PubMed  Google Scholar 

  46. Grogg KL, Nascimento AG. Subcutaneous granuloma annulare in childhood: clinicopathologic features in 34 cases. Pediatrics. 2001;107(3):E42.

    Article  CAS  PubMed  Google Scholar 

  47. Hata N, Inamura T, Imayama S, Morioka T, Nishio S, Miyazono M, Fukui M, Iwaki T. Multiple palisading granulomas in the scalp of an infant: a case report. Surg Neurol. 2001;56(6):396–9.

    Article  CAS  PubMed  Google Scholar 

  48. McDermott MB, Lind AC, Marley EF, Dehner LP. Deep granuloma annulare (pseudorheumatoid nodule) in children: clinicopathologic study of 35 cases. Pediatr Dev Pathol. 1998;1(4):300–8.

    Article  CAS  PubMed  Google Scholar 

  49. Felner EI, Steinberg JB, Weinberg AG. Subcutaneous granuloma annulare: a review of 47 cases. Pediatrics. 1997;100(6):965–7.

    Article  CAS  PubMed  Google Scholar 

  50. Avitan-Hersh E, Sprecher H, Ramon M, Bergman R. Does infection play a role in the pathogenesis of granuloma annulare? J Am Acad Dermatol. 2013;68(2):342–3.

    Article  PubMed  Google Scholar 

  51. Friedman-Birnbaum R, Gideoni O, Bergman R, Pollack S. A study of HLA antigen association in localized and generalized granuloma annulare. Br J Dermatol. 1986;115(3):329–33.

    Article  CAS  PubMed  Google Scholar 

  52. Buechner SA, Winkelmann RK, Banks PM. Identification of T-cell subpopulations in granuloma annulare. Arch Dermatol. 1983;119(2):125–8.

    Article  CAS  PubMed  Google Scholar 

  53. Stefanaki K, Tsivitanidou-Kakourou T, Stefanaki C, Valari M, Argyrakos T, Konstantinidou CV, Karentzou O, Katsambas A. Histological and immunohistochemical study of granuloma annulare and subcutaneous granuloma annulare in children. J Cutan Pathol. 2007;34(5):392–6.

    Article  PubMed  Google Scholar 

  54. Scaramuzza A, Macedoni M, Tadini GL, De Angelis L, Redaelli F, Gazzarri A, Comaschi V, Giani E, Zuccotti GV. Necrobiosis lipoidica diabeticorum. Case Rep Pediatr. 2012;2012:152602.

    PubMed  PubMed Central  Google Scholar 

  55. Bonura C, Frontino G, Rigamonti A, Battaglino R, Favalli V, Ferro G, Rubino C, Del Barba P, Pesapane F, Nazzaro G, Gianotti R, Bonfanti R, Meschi F, Chiumello G. Necrobiosis Lipoidica Diabeticorum: a pediatric case report. Dermatoendocrinology. 2014;6(1):e27790.

    Article  Google Scholar 

  56. Pavlovic MD, Milenkovic T, Dinic M, Misovic M, Dakovic D, Todorovic S, Dakovic Z, Zecevi RD, Doder R. The prevalence of cutaneous manifestations in young patients with type 1 diabetes. Diabetes Care. 2007;30(8):1964–7.

    Article  PubMed  Google Scholar 

  57. Muller SA, Winkelmann RK. Necrobiosis lipoidica diabeticorum. A clinical and pathological investigation of 171 cases. Arch Dermatol. 1966;93(3):272–81.

    Article  CAS  PubMed  Google Scholar 

  58. Edidin DV. Cutaneous manifestations of diabetes mellitus in children. Pediatr Dermatol. 1985;2(3):161–79.

    Article  CAS  PubMed  Google Scholar 

  59. Beck HI, Bjerring P. Skin blood flow in necrobiosis lipoidica during treatment with low-dose acetylsalicylic acid. Acta Derm Venereol. 1988;68(4):364–5.

    CAS  PubMed  Google Scholar 

  60. Jahr U, Sodemann K, Kirsch G, Mehnert E. Peripheral blood flow in patients with necrobiosis lipoidica (diabeticorum). Z Gesamte Inn Med. 1979;34(22):681–5.

    CAS  PubMed  Google Scholar 

  61. Reid SD, Ladizinski B, Lee K, Baibergenova A, Alavi A. Update on necrobiosis lipoidica: a review of etiology, diagnosis, and treatment options. J Am Acad Dermatol. 2013;69(5):783–91.

    Article  PubMed  Google Scholar 

  62. Ngo B, Wigington G, Hayes K, Huerter C, Hillman B, Adler M, Rendell M. Skin blood flow in necrobiosis lipoidica diabeticorum. Int J Dermatol. 2008;47(4):354–8.

    Article  PubMed  Google Scholar 

  63. Simons FE, Schaller JG. Benign rheumatoid nodules. Pediatrics. 1975;56(1):29–33.

    CAS  PubMed  Google Scholar 

  64. Mastboom WJ, van der Staak FH, Festen C, Postma MH. Subcutaneous rheumatoid nodules. Arch Dis Child. 1988;63(6):662–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Muzaffer MA, Schneider R, Cameron BJ, Silverman ED, Laxer RM. Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis. J Pediatr. 1996;128(5 Pt 1):698–700.

    Article  CAS  PubMed  Google Scholar 

  66. Tilstra JS, Lienesch DW. Rheumatoid nodules. Dermatol Clin. 2015;33(3):361–71.

    Article  CAS  PubMed  Google Scholar 

  67. Nyhall-Wahlin BM, Jacobsson LT, Petersson IF, Turesson C. Smoking is a strong risk factor for rheumatoid nodules in early rheumatoid arthritis. Ann Rheum Dis. 2006;65(5):601–6.

    Article  PubMed  Google Scholar 

  68. Sayah A, English 3rd JC. Rheumatoid arthritis: a review of the cutaneous manifestations. J Am Acad Dermatol. 2005;53(2):191–209. quiz 210–2.

    Article  PubMed  Google Scholar 

  69. Hunt RD, Hartman RD, Molho-Pessach V, Votava HJ, Schaffer JV. Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. J Am Acad Dermatol. 2012;67(4):e164–6.

    Article  PubMed  Google Scholar 

  70. Biswas A, Chittari K, Gey van Pittius D, Stephens M, Tan BB. Palisaded neutrophilic and granulomatous dermatitis in a child with type I diabetes mellitus and coeliac disease. Br J Dermatol. 2008;159(2):488–9.

    Article  CAS  PubMed  Google Scholar 

  71. Chu P, Connolly MK, LeBoit PE. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol. 1994;130(10):1278–83.

    Article  CAS  PubMed  Google Scholar 

  72. Comfere NI, Macaron NC, Gibson LE. Cutaneous manifestations of Wegener’s granulomatosis: a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status. J Cutan Pathol. 2007;34(10):739–47.

    Article  PubMed  Google Scholar 

  73. Rosenbach M, English 3rd JC. Reactive granulomatous dermatitis: a review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin. 2015;33(3):373–87.

    Article  CAS  PubMed  Google Scholar 

  74. Deng A, Harvey V, Sina B, Strobel D, Badros A, Junkins-Hopkins JM, Samuels A, Oghilikhan M, Gaspari A. Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. Arch Dermatol. 2006;142(2):198–202.

    Article  PubMed  Google Scholar 

  75. Al-Daraji WI, Coulson IH, Howat AJ. Palisaded neutrophilic and granulomatous dermatitis. Clin Exp Dermatol. 2005;30(5):578–9.

    Article  CAS  PubMed  Google Scholar 

  76. Misago N, Shinoda Y, Tago M, Narisawa Y. Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date. J Cutan Pathol. 2009;37(10):1092–7.

    Article  PubMed  Google Scholar 

  77. Dodi I, Verri R, Brevi B, Bonetti L, Balestrier A, Saracino A, Akamin R, Izzi GC, Vanelli M, Sesenna E. A monosymptomatic Melkersson-Rosenthal syndrome in an 8-year old boy. Acta Biomed. 2006;77(1):20–3.

    PubMed  Google Scholar 

  78. Lee Y-J, Cheon CK, Yeon GM, Kim YM, Nam SO. Melkersson-Rosenthal syndrome with Hashimoto thyroiditis in a 9-year-old girl: an autoimmune disorder. Pediatr Neurol. 2014;50(5):503–6.

    Article  PubMed  Google Scholar 

  79. Răchişan AL, Hruşcă A, Gheban D, Căinap S, Pop TL, Băican A, Fodor L, Miu N, Andreica M. Granulomatous cheilitis of Miescher: the diagnostic proof for a Melkersson-Rosenthal syndrome. Rom J Morphol Embryol. 2012;53(3 Suppl):851–3.

    PubMed  Google Scholar 

  80. Yilmaz U, Cubukçu D, Yilmaz TS, Akinci G, Ozcan M, Güzel O. Peripheral facial palsy in children. J Child Neurol. 2014;29(11):1473–8.

    Google Scholar 

  81. Kaminagakura E, Jorge Jr J. Melkersson Rosenthal syndrome: a histopathologic mystery and dermatologic challenge. J Cutan Pathol. 2011;38(2):241–5.

    Article  PubMed  Google Scholar 

  82. Ahmad I, Owens D. Granulomatous cheilitis and Crohn’s disease. Can J Gastroenterol. 2001;15(4):273–5.

    Article  CAS  PubMed  Google Scholar 

  83. Khouri JM, Bohane TD, Day AS. Is orofacial granulomatosis in children a feature of Crohn’s disease? Acta Paediatr. 2005;94(4):501–4.

    Article  CAS  PubMed  Google Scholar 

  84. Al-Hamad A, Porter S, Fedele S. Orofacial Granulomatosis. Dermatol Clin. 2015;33(3):433–46.

    Article  CAS  PubMed  Google Scholar 

  85. Gibson J, Wray D. Human leucocyte antigen typing in orofacial granulomatosis. Br J Dermatol. 2000;143(5):1119–21.

    Article  CAS  PubMed  Google Scholar 

  86. Ronnblom L, Forsum U, Evrin PE, Gillnas T, Nethander G. Intralesional T lymphocyte phenotypes and HLA-DR expression in Melkersson-Rosenthal syndrome. Int J Oral Maxillofac Surg. 1986;15(5):614–9.

    Article  CAS  PubMed  Google Scholar 

  87. Patton DW, Ferguson MM, Forsyth A, James J. Oro-facial granulomatosis: a possible allergic basis. Br J Oral Maxillofac Surg. 1985;23(4):235–42.

    Article  CAS  PubMed  Google Scholar 

  88. Zimmer WM, Rogers 3rd RS, Reeve CM, Sheridan PJ. Orofacial manifestations of Melkersson-Rosenthal syndrome. A study of 42 patients and review of 220 cases from the literature. Oral Surg Oral Med Oral Pathol. 1992;74(5):610–9.

    Article  CAS  PubMed  Google Scholar 

  89. Kano Y, Shiohara T, Yagita A, Nagashima M. Association between cheilitis granulomatosa and Crohn’s disease. J Am Acad Dermatol. 1993;28(5 Pt 1):801.

    Article  CAS  PubMed  Google Scholar 

  90. Lazzerini M, Bramuzzo M, Ventura A. Association between orofacial granulomatosis and Crohn’s disease in children: systematic review. World J Gastroenterol. 2014;20(23):7497–504.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Riggio MP, Gibson J, Lennon A, Wray D, MacDonald DG. Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn’s disease tissue by polymerase chain reaction. Gut. 1997;41(5):646–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Paller AS, Mancini AJ. Hurwitz clinical pediatric dermatology. Philadelphia: Elsevier; 2006.

    Google Scholar 

  93. Kim SC, Ferry GD. Inflammatory bowel diseases in pediatric and adolescent patients: clinical, therapeutic, and psychosocial considerations. Gastroenterology. 2004;126(6):1550–60.

    Article  PubMed  Google Scholar 

  94. Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, Bourke B. The oral cavity in Crohn’s disease. J Pediatr. 2001;138(5):767–71.

    Article  CAS  PubMed  Google Scholar 

  95. Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W. Orofacial granulomatosis as the initial presentation of Crohn’s disease in an adolescent. Dermatology. 2003;206(3):273–8.

    Article  PubMed  Google Scholar 

  96. Murphy MJ, Kogan B, Carlson JA. Granulomatous lymphangitis of the scrotum and penis. Report of a case and review of the literature of genital swelling with sarcoidal granulomatous inflammation. J Cutan Pathol. 2001;28(8):419–24.

    Article  CAS  PubMed  Google Scholar 

  97. Schroeder B. Vulvar disorders in adolescents. Obstet Gynecol Clin North Am. 2000;27(1):35–48.

    Article  CAS  PubMed  Google Scholar 

  98. Smoller BR, Weishar M, Gray MH. An unusual cutaneous manifestation of Crohn’s disease. Arch Pathol Lab Med. 1990;114(6):609–10.

    CAS  PubMed  Google Scholar 

  99. Thrash B, Patel M, Shah KR, Boland CR, Menter A. Cutaneous manifestations of gastrointestinal disease: Part II. J Am Acad Dermatol. 2013;68(2):211.e211–33; quiz 244–6.

    Google Scholar 

  100. Hackzell-Bradley M, Hedblad MA, Stephansson EA. Metastatic Crohn’s disease. Report of 3 cases with special reference to histopathologic findings. Arch Dermatol. 1996;132(8):928–32.

    Article  CAS  PubMed  Google Scholar 

  101. Perret CM, Bahmer FA. Extensive necrobiosis in metastatic Crohn’s disease. Dermatologica. 1987;175(4):208–12.

    Article  CAS  PubMed  Google Scholar 

  102. Boyapati R, Satsangi J, Ho GT. Pathogenesis of Crohn’s disease. F1000Prime Rep. 2015;7:44.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  103. Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJ, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122(4):867–74.

    Article  CAS  PubMed  Google Scholar 

  104. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411(6837):599–603.

    Article  CAS  PubMed  Google Scholar 

  105. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn’s disease. J Biol Chem. 2003;278(8):5509–12.

    Article  CAS  PubMed  Google Scholar 

  106. Strober W, Asano N, Fuss I, Kitani A, Watanabe T. Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn’s disease. Immunol Rev. 2014;260(1):249–60.

    Article  CAS  PubMed  Google Scholar 

  107. Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease. Gut. 2008;57(7):903–10.

    Article  CAS  PubMed  Google Scholar 

  108. Noble CL, Nimmo ER, Drummond H, Ho GT, Tenesa A, Smith L, Anderson N, Arnott ID, Satsangi J. The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn’s disease. Gastroenterology. 2005;129(6):1854–64.

    Article  CAS  PubMed  Google Scholar 

  109. Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, Griffiths AM, St George-Hyslop PH, Siminovitch KA. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet. 2004;36(5):471–5.

    Article  CAS  PubMed  Google Scholar 

  110. Sartor RB. Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006;3(7):390–407.

    Article  CAS  PubMed  Google Scholar 

  111. Stoll M, Corneliussen B, Costello CM, Waetzig GH, Mellgard B, Koch WA, Rosenstiel P, Albrecht M, Croucher PJ, Seegert D, Nikolaus S, Hampe J, Lengauer T, Pierrou S, Foelsch UR, Mathew CG, Lagerstrom-Fermer M, Schreiber S. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet. 2004;36(5):476–80.

    Article  CAS  PubMed  Google Scholar 

  112. Brant SR, Panhuysen CI, Nicolae D, Reddy DM, Bonen DK, Karaliukas R, Zhang L, Swanson E, Datta LW, Moran T, Ravenhill G, Duerr RH, Achkar JP, Karban AS, Cho JH. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet. 2003;73(6):1282–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Sugawara K, Olson TS, Moskaluk CA, Stevens BK, Hoang S, Kozaiwa K, Cominelli F, Ley KF, McDuffie M. Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn’s disease. Gastroenterology. 2005;128(2):351–60.

    Article  CAS  PubMed  Google Scholar 

  114. Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39(2):207–11.

    Article  CAS  PubMed  Google Scholar 

  115. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Izcue A, Hue S, Buonocore S, Arancibia-Carcamo CV, Ahern PP, Iwakura Y, Maloy KJ, Powrie F. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity. 2008;28(4):559–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Bamba T, Fujiyama Y. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52(1):65–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Schmidt C, Giese T, Ludwig B, Mueller-Molaian I, Marth T, Zeuzem S, Meuer SC, Stallmach A. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn’s disease but not in ulcerative colitis. Inflamm Bowel Dis. 2005;11(1):16–23.

    Article  PubMed  Google Scholar 

  119. Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006;116(5):1310–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Geremia A, Arancibia-Carcamo CV, Fleming MP, Rust N, Singh B, Mortensen NJ, Travis SP, Powrie F. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med. 2011;208(6):1127–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  121. Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, Artis D, Sonnenberg GF. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013;498(7452):113–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group. N Engl J Med. 1997;337(15):1029–35.

    Article  CAS  PubMed  Google Scholar 

  123. Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J. Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut. 2006;55(2):205–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  124. Choi YL, Lee KJ, Cho HJ, Kim WS, Lee JH, Yang JM, Lee ES, Lee DY. Case of childhood granulomatous periorificial dermatitis in a Korean boy treated by oral erythromycin. J Dermatol. 2006;33(11):806–8.

    Article  PubMed  Google Scholar 

  125. Tarm K, Creel NB, Krivda SJ, Turiansky GW. Granulomatous periorificial dermatitis. Cutis. 2004;73(6):399–402.

    PubMed  Google Scholar 

  126. Lucas CR, Korman NJ, Gilliam AC. Granulomatous periorificial dermatitis: a variant of granulomatous rosacea in children? J Cutan Med Surg. 2009;13(2):115–8.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Neri I, Raone B, Dondi A, Misciali C, Patrizi A. Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases. Pediatr Dermatol. 2013;30(1):109–11.

    Article  PubMed  Google Scholar 

  128. Laymon CW, Schoch Jr EP. Micropapular tuberculid and rosacea; a clinical and histologic comparison. Arch Derm Syphilol. 1948;58(3):286–300.

    Article  CAS  PubMed  Google Scholar 

  129. Hodak E, Trattner A, Feuerman H, Feinmesser M, Tsvieli R, Mitrani-Rosenbaum S, David M. Lupus miliaris disseminatus faciei—the DNA of Mycobacterium tuberculosis is not detectable in active lesions by polymerase chain reaction. Br J Dermatol. 1997;137(4):614–9.

    Article  CAS  PubMed  Google Scholar 

  130. Rocas D, Kanitakis J. Lupus miliaris disseminatus faciei: report of a new case and brief literature review. Dermatol Online J. 2013;19(3):4.

    PubMed  Google Scholar 

  131. el Darouti M, Zaher H. Lupus miliaris disseminatus faciei—pathologic study of early, fully developed, and late lesions. Int J Dermatol. 1993;32(7):508–11.

    Article  PubMed  Google Scholar 

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Phung, T.L., Wright, T.S., Pourciau, C.Y., Smoller, B.R. (2017). Granulomatous Eruptions. In: Pediatric Dermatopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-44824-4_6

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