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Dermatoses with Minimal Epidermal Changes

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Pediatric Dermatopathology

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Abstract

This group of skin disorders is clinically varied but characterized histologically by an inflammatory infiltrate primarily localized to the dermis. Some of the described conditions represent reactive cutaneous processes or phenotypic demonstrations of genetic mutations while others are idiopathic.

With special contributions from Haider Mejbel, MD, Baylor College of Medicine.

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References

  1. Bottoni U, Innocenzi D, Bonaccorsi P, Carlesimo M, Faina P, Richetta A, Cugini P, Calvieri S. Erythema annulare centrifugum: report of a case with neonatal onset. J Eur Acad Dermatol Venereol. 2002;16(5):500–3.

    Article  CAS  PubMed  Google Scholar 

  2. Kim KJ, Chang SE, Choi JH, Sung KJ, Moon KC, Koh JK. Clinicopathologic analysis of 66 cases of erythema annulare centrifugum. J Dermatol. 2002;29(2):61–7.

    Article  PubMed  Google Scholar 

  3. Weyers W, Diaz-Cascajo C, Weyers I. Erythema annulare centrifugum: results of a clinicopathologic study of 73 patients. Am J Dermatopathol. 2003;25(6):451–62.

    Article  PubMed  Google Scholar 

  4. Ziemer M, Eisendle K, Zelger B. New concepts on erythema annulare centrifugum: a clinical reaction pattern that does not represent a specific clinicopathological entity. Br J Dermatol. 2009;160(1):119–26.

    Article  CAS  PubMed  Google Scholar 

  5. Holt PJ, Davies MG. Erythema gyratum repens—an immunologically mediated dermatosis? Br J Dermatol. 1977;96(4):343–7.

    Article  CAS  PubMed  Google Scholar 

  6. Tyring SK. Reactive erythemas: erythema annulare centrifugum and erythema gyratum repens. Clin Dermatol. 1993;11(1):135–9.

    Article  CAS  PubMed  Google Scholar 

  7. Harrison PV. The annular erythemas. Int J Dermatol. 1979;18(4):282–90.

    Article  CAS  PubMed  Google Scholar 

  8. Hsu S, Le EH, Khoshevis MR. Differential diagnosis of annular lesions. Am Fam Physician. 2001;64(2):289–96.

    CAS  PubMed  Google Scholar 

  9. Torrelo A, Requena C, Mediero IG, Zambrano A. Schamberg’s purpura in children: a review of 13 cases. J Am Acad Dermatol. 2003;48(1):31–3.

    Article  PubMed  Google Scholar 

  10. Sardana K, Sarkar R, Sehgal VN. Pigmented purpuric dermatoses: an overview. Int J Dermatol. 2004;43(7):482–8.

    Article  PubMed  Google Scholar 

  11. Herisse AL, Chiaverini C, Boralevi F, Maruani A, Phan A, Lacour JP. Progressive pigmented purpuric dermatosis in young children. Ann Dermatol Venereol. 2014;141(5):331–5.

    Article  PubMed  Google Scholar 

  12. Kim MJ, Kim BY, Park KC, Youn SW. A case of childhood lichen aureus. Ann Dermatol. 2009;21(4):393–5.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kaplan R, Meehan SA, Leger M. A case of isotretinoin-induced purpura annularis telangiectodes of Majocchi and review of substance-induced pigmented purpuric dermatosis. JAMA Dermatol. 2013;150(2):182–4.

    Article  Google Scholar 

  14. Tristani-Firouzi P, Meadows KP, Vanderhooft S. Pigmented purpuric eruptions of childhood: a series of cases and review of literature. Pediatr Dermatol. 2001;18(4):299–304.

    Article  CAS  PubMed  Google Scholar 

  15. Pang BK, Su D, Ratnam KV. Drug-induced purpura simplex: clinical and histological characteristics. Ann Acad Med Singapore. 1993;22(6):870–2.

    CAS  PubMed  Google Scholar 

  16. Ghersetich I, Lotti T, Bacci S, Comacchi C, Campanile G, Romagnoli P. Cell infiltrate in progressive pigmented purpura (Schamberg’s disease): immunophenotype, adhesion receptors, and intercellular relationships. Int J Dermatol. 1995;34(12):846–50.

    Article  CAS  PubMed  Google Scholar 

  17. Iwatsuki K, Aoshima T, Tagami H, Ohi M, Yamada M. Immunofluorescence study in purpura pigmentosa chronica. Acta Derm Venereol. 1980;60(4):341–5.

    CAS  PubMed  Google Scholar 

  18. Baselga E, Drolet BA, Esterly NB. Purpura in infants and children. J Am Acad Dermatol. 1997;37(5 Pt 1):673–705. quiz 706–7.

    Article  CAS  PubMed  Google Scholar 

  19. Sackesen C, Sekerel BE, Orhan F, Kocabas CN, Tuncer A, Adalioglu G. The etiology of different forms of urticaria in childhood. Pediatr Dermatol. 2004;21(2):102–8.

    Article  PubMed  Google Scholar 

  20. Zitelli KB, Cordoro KM. Evidence-based evaluation and management of chronic urticaria in children. Pediatr Dermatol. 2011;28(6):629–39.

    Article  PubMed  Google Scholar 

  21. Shah KN, Honig PJ, Yan AC. “Urticaria multiforme”: a case series and review of acute annular urticarial hypersensitivity syndromes in children. Pediatrics. 2007;119(5):e1177–83.

    Article  PubMed  Google Scholar 

  22. Steen CJ, Carbonaro PA, Schwartz RA. Arthropods in dermatology. J Am Acad Dermatol. 2004;50(6):819–42. quiz 842–4.

    Article  PubMed  Google Scholar 

  23. Nousari HC, Kimyai-Asadi A, Ketabchi N, Cohen BA. Urticarial eruption associated with rheumatic fever in a child. Pediatr Dermatol. 1999;16(4):288–91.

    Article  CAS  PubMed  Google Scholar 

  24. Toyoda M, Maruyama T, Morohashi M, Bhawan J. Free eosinophil granules in urticaria: a correlation with the duration of wheals. Am J Dermatopathol. 1996;18(1):49–57.

    Article  CAS  PubMed  Google Scholar 

  25. Sanchez JL, Benmaman O. Clinicopathological correlation in chronic urticaria. Am J Dermatopathol. 1992;14(3):220–3.

    Article  CAS  PubMed  Google Scholar 

  26. Zembowicz A, Mastalerz L, Setkowicz M, Radziszewski W, Szczeklik A. Histological spectrum of cutaneous reactions to aspirin in chronic idiopathic urticaria. J Cutan Pathol. 2004;31(4):323–9.

    Article  PubMed  Google Scholar 

  27. Peteiro C, Toribio J. Incidence of leukocytoclastic vasculitis in chronic idiopathic urticaria. Study of 100 cases. Am J Dermatopathol. 1989;11(6):528–33.

    Article  CAS  PubMed  Google Scholar 

  28. Jordaan HF, Schneider JW. Papular urticaria: a histopathologic study of 30 patients. Am J Dermatopathol. 1997;19(2):119–26.

    Article  CAS  PubMed  Google Scholar 

  29. Schorr WF, Tauscheck AL, Dickson KB, Melski JW. Eosinophilic cellulitis (Wells’ syndrome): histologic and clinical features in arthropod bite reactions. J Am Acad Dermatol. 1984;11(6):1043–9.

    Article  CAS  PubMed  Google Scholar 

  30. Haas N, Schadendorf D, Henz BM. Differential endothelial adhesion molecule expression in early and late whealing reactions. Int Arch Allergy Immunol. 1998;115(3):210–4.

    Article  CAS  PubMed  Google Scholar 

  31. Kaplan AP. Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol. 2004;114(3):465–74. quiz 475.

    Article  CAS  PubMed  Google Scholar 

  32. Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls AF, Askenase PW, Kay AB. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol. 1999;163(7):3976–84.

    CAS  PubMed  Google Scholar 

  33. Peters MS, Schroeter AL, Gleich GJ. Immunofluorescence identification of eosinophil granule major basic protein in the flame figures of Wells’ syndrome. Br J Dermatol. 1983;109(2):141–8.

    Article  CAS  PubMed  Google Scholar 

  34. Haas N, Toppe E, Henz BM. Microscopic morphology of different types of urticaria. Arch Dermatol. 1998;134(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  35. Sabroe RA, Poon E, Orchard GE, Lane D, Francis DM, Barr RM, Black MM, Black AK, Greaves MW. Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies. J Allergy Clin Immunol. 1999;103(3 Pt 1):484–93.

    Article  CAS  PubMed  Google Scholar 

  36. Lourenco FD, Azor MH, Santos JC, Prearo E, Maruta CW, Rivitti EA, Duarte AJ, Sato MN. Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus. Br J Dermatol. 2008;158(5):979–86.

    Article  CAS  PubMed  Google Scholar 

  37. Mlynek A, Maurer M, Zalewska A. Update on chronic urticaria: focusing on mechanisms. Curr Opin Allergy Clin Immunol. 2008;8(5):433–7.

    Article  PubMed  Google Scholar 

  38. Kern F, Lichtenstein LM. Defective histamine release in chronic urticaria. J Clin Invest. 1976;57(5):1369–77.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Sabroe RA, Francis DM, Barr RM, Black AK, Greaves MW. Anti-Fc(episilon)RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria. J Allergy Clin Immunol. 1998;102(4 Pt 1):651–8.

    Article  CAS  PubMed  Google Scholar 

  40. Asero R, Tedeschi A, Coppola R, Griffini S, Paparella P, Riboldi P, Marzano AV, Fanoni D, Cugno M. Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria. J Allergy Clin Immunol. 2007;119(3):705–10.

    Article  CAS  PubMed  Google Scholar 

  41. Asero R, Riboldi P, Tedeschi A, Cugno M, Meroni P. Chronic urticaria: a disease at a crossroad between autoimmunity and coagulation. Autoimmun Rev. 2007;7(1):71–6.

    Article  CAS  PubMed  Google Scholar 

  42. Kasperska-Zajac A, Brzoza Z, Rogala B. Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria. Cytokine. 2007;39(2):142–6.

    Article  CAS  PubMed  Google Scholar 

  43. Kasperska-Zajac A, Brzoza Z, Rogala B. Dehydroepiandrosterone and dehydroepiandrosterone sulphate in atopic allergy and chronic urticaria. Inflammation. 2008;31(3):141–5.

    Article  CAS  PubMed  Google Scholar 

  44. Demain JG. Papular urticaria and things that bite in the night. Curr Allergy Asthma Rep. 2003;3(4):291–303.

    Article  PubMed  Google Scholar 

  45. Hebert AA, Esterly NB. Annular erythema of infancy. J Am Acad Dermatol. 1986;14(2 Pt 2):339–43.

    Article  CAS  PubMed  Google Scholar 

  46. Helm TN, Bass J, Chang LW, Bergfeld WF. Persistent annular erythema of infancy. Pediatr Dermatol. 1993;10(1):46–8.

    Article  CAS  PubMed  Google Scholar 

  47. Patrizi A, Savoia F, Varotti E, Gaspari V, Passarini B, Neri I. Neutrophilic figurate erythema of infancy. Pediatr Dermatol. 2008;25(2):255–60.

    Article  PubMed  Google Scholar 

  48. Cox NH, McQueen A, Evans TJ, Morley WN. An annular erythema of infancy. Arch Dermatol. 1987;123(4):510–3.

    Article  CAS  PubMed  Google Scholar 

  49. McGinley-Smith DE, Tsao SS. Dermatoses from ticks. J Am Acad Dermatol. 2003;49(3):363–92. quiz 393–6.

    Article  PubMed  Google Scholar 

  50. Mullegger RR, Glatz M. Skin manifestations of lyme borreliosis: diagnosis and management. Am J Clin Dermatol. 2008;9(6):355–68.

    Article  PubMed  Google Scholar 

  51. Mullegger RR. Dermatological manifestations of Lyme borreliosis. Eur J Dermatol. 2004;14(5):296–309.

    PubMed  Google Scholar 

  52. Van Mierlo P, Jacob W, Dockx P. Erythema chronicum migrans: an electron-microscopic study. Dermatology. 1993;186(4):306–10.

    Article  PubMed  Google Scholar 

  53. Wilson TC, Legler A, Madison KC, Fairley JA, Swick BL. Erythema migrans: a spectrum of histopathologic changes. Am J Dermatopathol. 2012;34(8):834–7.

    Article  PubMed  Google Scholar 

  54. Wu YS, Zhang WF, Feng FP, Wang BZ, Zhang YJ. Atypical cutaneous lesions of Lyme disease. Clin Exp Dermatol. 1993;18(5):434–6.

    Article  CAS  PubMed  Google Scholar 

  55. Jurca T, Ruzic-Sabljic E, Lotric-Furlan S, Maraspin V, Cimperman J, Picken RN, Strle F. Comparison of peripheral and central biopsy sites for the isolation of Borrelia burgdorferi sensu lato from erythema migrans skin lesions. Clin Infect Dis. 1998;27(3):636–8.

    Article  CAS  PubMed  Google Scholar 

  56. Miraflor AP, Seidel GD, Perry AE, Castanedo-Tardan MP, Guill MA, Yan S. The many masks of cutaneous Lyme disease. J Cutan Pathol. 2016;43(1):32–40.

    Article  PubMed  Google Scholar 

  57. Boer A, Bresch M, Dayrit J, Falk TM. Erythema migrans: a reassessment of diagnostic criteria for early cutaneous manifestations of borreliosis with particular emphasis on clonality investigations. Br J Dermatol. 2007;156(6):1263–71.

    Article  CAS  PubMed  Google Scholar 

  58. Moreno C, Kutzner H, Palmedo G, Goerttler E, Carrasco L, Requena L. Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. J Am Acad Dermatol. 2003;48(3):376–84.

    Article  PubMed  Google Scholar 

  59. Asbrink E, Brehmer-Andersson E, Hovmark A. Acrodermatitis chronica atrophicans—a spirochetosis. Clinical and histopathological picture based on 32 patients; course and relationship to erythema chronicum migrans Afzelius. Am J Dermatopathol. 1986;8(3):209–19.

    Article  CAS  PubMed  Google Scholar 

  60. Dandache P, Nadelman RB. Erythema migrans. Infect Dis Clin North Am. 2008;22(2):235–60. vi.

    Article  PubMed  Google Scholar 

  61. Krause PJ, Telford 3rd SR, Spielman A, Sikand V, Ryan R, Christianson D, Burke G, Brassard P, Pollack R, Peck J, Persing DH. Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. JAMA. 1996;275(21):1657–60.

    Article  CAS  PubMed  Google Scholar 

  62. Melski JW, Reed KD, Mitchell PD, Barth GD. Primary and secondary erythema migrans in central Wisconsin. Arch Dermatol. 1993;129(6):709–16.

    Article  CAS  PubMed  Google Scholar 

  63. Weber K, Preac-Mursic V, Wilske B, Thurmayr R, Neubert U, Scherwitz C. A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection. 1990;18(2):91–6.

    Article  CAS  PubMed  Google Scholar 

  64. Wormser GP, McKenna D, Carlin J, Nadelman RB, Cavaliere LF, Holmgren D, Byrne DW, Nowakowski J. Brief communication: hematogenous dissemination in early Lyme disease. Ann Intern Med. 2005;142(9):751–5.

    Article  PubMed  Google Scholar 

  65. Brown EL, Wooten RM, Johnson BJ, Iozzo RV, Smith A, Dolan MC, Guo BP, Weis JJ, Hook M. Resistance to Lyme disease in decorin-deficient mice. J Clin Invest. 2001;107(7):845–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Petzke M, Schwartz I. Borrelia burgdorferi pathogenesis and the immune response. Clin Lab Med. 2015;35(4):745–64.

    Article  PubMed  Google Scholar 

  67. Zhang JR, Hardham JM, Barbour AG, Norris SJ. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell. 1997;89(2):275–85.

    Article  CAS  PubMed  Google Scholar 

  68. Zhang JR, Norris SJ. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infect Immun. 1998;66(8):3698–704.

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Kraiczy P, Skerka C, Brade V, Zipfel PF. Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect Immun. 2001;69(12):7800–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Kraiczy P, Stevenson B. Complement regulator-acquiring surface proteins of Borrelia burgdorferi: structure, function and regulation of gene expression. Ticks Tick Borne Dis. 2012;4(1–2):26–34.

    PubMed  PubMed Central  Google Scholar 

  71. Torok KS. Pediatric scleroderma: systemic or localized forms. Pediatr Clin North Am. 2012;59(2):381–405.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Careta MF, Romiti R. Localized scleroderma: clinical spectrum and therapeutic update. An Bras Dermatol. 2015;90(1):62–73.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Browning JC. Pediatric morphea. Dermatol Clin. 2013;31(2):229–37.

    Article  CAS  PubMed  Google Scholar 

  74. Piram M, McCuaig CC, Saint-Cyr C, Marcoux D, Hatami A, Haddad E, Powell J. Short- and long-term outcome of linear morphoea in children. Br J Dermatol. 2013;169(6):1265–71.

    Article  CAS  PubMed  Google Scholar 

  75. Rahbari H. Histochemical differentiation of localized morphea-scleroderma and lichen sclerosus et atrophicus. J Cutan Pathol. 1989;16(6):342–7.

    Article  CAS  PubMed  Google Scholar 

  76. Sung JJ, Chen TS, Gilliam AC, McCalmont TH, Gilliam AE. Clinicohistopathological correlations in juvenile localized scleroderma: studies on a subset of children with hypopigmented juvenile localized scleroderma due to loss of epidermal melanocytes. J Am Acad Dermatol. 2011;65(2):364–73.

    Article  PubMed  Google Scholar 

  77. Walters R, Pulitzer M, Kamino H. Elastic fiber pattern in scleroderma/morphea. J Cutan Pathol. 2009;36(9):952–7.

    Article  PubMed  Google Scholar 

  78. Uitto J, Santa Cruz DJ, Bauer EA, Eisen AZ. Morphea and lichen sclerosus et atrophicus. Clinical and histopathologic studies in patients with combined features. J Am Acad Dermatol. 1980;3(3):271–9.

    Article  CAS  PubMed  Google Scholar 

  79. McNiff JM, Glusac EJ, Lazova RZ, Carroll CB. Morphea limited to the superficial reticular dermis: an underrecognized histologic phenomenon. Am J Dermatopathol. 1999;21(4):315–9.

    Article  CAS  PubMed  Google Scholar 

  80. Badea I, Taylor M, Rosenberg A, Foldvari M. Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis. Rheumatology (Oxford). 2009;48(3):213–21.

    Article  CAS  Google Scholar 

  81. Gambichler T, Skrygan M, Labanski AA, Kolios AG, Altmeyer P, Kreuter A. Significantly increased CCL5/RANTES and CCR7 mRNA levels in localized scleroderma. Regul Pept. 2011;170(1–3):4–6.

    Article  CAS  PubMed  Google Scholar 

  82. Yamamoto T. Chemokines and chemokine receptors in scleroderma. Int Arch Allergy Immunol. 2006;140(4):345–56.

    Article  CAS  PubMed  Google Scholar 

  83. Fett N. Scleroderma: nomenclature, etiology, pathogenesis, prognosis, and treatments: facts and controversies. Clin Dermatol. 2013;31(4):432–7.

    Article  PubMed  Google Scholar 

  84. Kreuter A. Localized scleroderma. Dermatol Ther. 2012;25(2):135–47.

    Article  PubMed  Google Scholar 

  85. Kurzinski K, Torok KS. Cytokine profiles in localized scleroderma and relationship to clinical features. Cytokine. 2011;55(2):157–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117(3):557–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Firoz EF, Kamino H, Lehman TJ, Orlow SJ. Morphea, diabetes mellitus type I, and celiac disease: case report and review of the literature. Pediatr Dermatol. 2010;27(1):48–52.

    Article  PubMed  Google Scholar 

  88. Kim HS, Choi YJ, Park YM, Kim HO, Lee JY. Case of juvenile localized scleroderma with joint sclerosis and Sjogren’s syndrome in a child with precocious puberty. J Dermatol. 2011;38(10):1024–7.

    Article  PubMed  Google Scholar 

  89. Zulian F, Cuffaro G, Sperotto F. Scleroderma in children: an update. Curr Opin Rheumatol. 2013;25(5):643–50.

    Article  PubMed  Google Scholar 

  90. Romano E, Manetti M, Guiducci S, Ceccarelli C, Allanore Y, Matucci-Cerinic M. The genetics of systemic sclerosis: an update. Clin Exp Rheumatol. 2011;29(2 Suppl 65):S75–86.

    PubMed  Google Scholar 

  91. Arkachaisri T, Fertig N, Pino S, Medsger Jr TA. Serum autoantibodies and their clinical associations in patients with childhood- and adult-onset linear scleroderma. A single-center study. J Rheumatol. 2008;35(12):2439–44.

    Article  CAS  PubMed  Google Scholar 

  92. Takehara K, Sato S. Localized scleroderma is an autoimmune disorder. Rheumatology (Oxford). 2005;44(3):274–9.

    Article  CAS  Google Scholar 

  93. Hayakawa I, Hasegawa M, Takehara K, Sato S. Anti-DNA topoisomerase IIalpha autoantibodies in localized scleroderma. Arthritis Rheum. 2004;50(1):227–32.

    Article  CAS  PubMed  Google Scholar 

  94. Bleasel NR, Stapleton KM, Commens C, Ahern VA. Radiation-induced localized scleroderma in breast cancer patients. Australas J Dermatol. 1999;40(2):99–102.

    Article  CAS  PubMed  Google Scholar 

  95. Davis DA, Cohen PR, McNeese MD, Duvic M. Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: radiation port scleroderma. J Am Acad Dermatol. 1996;35(6):923–7.

    Article  CAS  PubMed  Google Scholar 

  96. Christen-Zaech S, Hakim MD, Afsar FS, Paller AS. Pediatric morphea (localized scleroderma): review of 136 patients. J Am Acad Dermatol. 2008;59(3):385–96.

    Article  PubMed  Google Scholar 

  97. Zulian F, Athreya BH, Laxer R, Nelson AM, Feitosa de Oliveira SK, Punaro MG, Cuttica R, Higgins GC, Van Suijlekom-Smit LW, Moore TL, Lindsley C, Garcia-Consuegra J, Esteves Hilario MO, Lepore L, Silva CA, Machado C, Garay SM, Uziel Y, Martini G, Foeldvari I, Peserico A, Woo P, Harper J. Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study. Rheumatology (Oxford). 2006;45(5):614–20.

    Article  CAS  Google Scholar 

  98. Torrelo A, Suarez J, Colmenero I, Azorin D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23(5):484–7.

    Article  PubMed  Google Scholar 

  99. Succaria F, Kurban M, Kibbi AG, Abbas O. Clinicopathological study of 81 cases of localized and systemic scleroderma. J Eur Acad Dermatol Venereol. 2012;27(2):e191–6.

    Article  PubMed  Google Scholar 

  100. Milano A, Pendergrass SA, Sargent JL, George LK, McCalmont TH, Connolly MK, Whitfield ML. Molecular subsets in the gene expression signatures of scleroderma skin. PLoS One. 2008;3(7):e2696.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  101. Simon TD, Soep JB, Hollister JR. Pernio in pediatrics. Pediatrics. 2005;116(3):e472–5.

    Article  PubMed  Google Scholar 

  102. Boada A, Bielsa I, Fernandez-Figueras MT, Ferrandiz C. Perniosis: clinical and histopathological analysis. Am J Dermatopathol. 2010;32(1):19–23.

    Article  PubMed  Google Scholar 

  103. Weston WL, Morelli JG. Childhood pernio and cryoproteins. Pediatr Dermatol. 2000;17(2):97–9.

    Article  CAS  PubMed  Google Scholar 

  104. Crowson AN, Magro CM. Idiopathic perniosis and its mimics: a clinical and histological study of 38 cases. Hum Pathol. 1997;28(4):478–84.

    Article  CAS  PubMed  Google Scholar 

  105. Kolivras A, Aeby A, Crow YJ, Rice GI, Sass U, Andre J. Cutaneous histopathological findings of Aicardi-Goutieres syndrome, overlap with chilblain lupus. J Cutan Pathol. 2008;35(8):774–8.

    Article  PubMed  Google Scholar 

  106. Nabatian AS, Rosman IS, Sturza J, Jacobson M. Juvenile spring eruption: a variant of perniosis? Am J Dermatopathol. 2015;37(9):721–3.

    Article  PubMed  Google Scholar 

  107. West SE, McCalmont TH, North JP. Ice-pack dermatosis: a cold-induced dermatitis with similarities to cold panniculitis and perniosis that histopathologically resembles lupus. JAMA Dermatol. 2013;149(11):1314–8.

    Article  PubMed  Google Scholar 

  108. Gordon R, Arikian AM, Pakula AS. Chilblains in Southern California: two case reports and a review of the literature. J Med Case Rep. 2014;8:381.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Prakash S, Weisman MH. Idiopathic chilblains. Am J Med. 2009;122(12):1152–5.

    Article  PubMed  Google Scholar 

  110. Nielsen T, Schmidt H, Sogaard H. Eosinophilic cellulitis. (Well’s syndrome) in a child. Arch Dermatol. 1981;117(7):427–9.

    Article  CAS  PubMed  Google Scholar 

  111. Ferreli C, Pinna AL, Atzori L, Aste N. Eosinophilic cellulitis (Well’s syndrome): a new case description. J Eur Acad Dermatol Venereol. 1999;13(1):41–5.

    Article  CAS  PubMed  Google Scholar 

  112. Wood C, Miller AC, Jacobs A, Hart R, Nickoloff BJ. Eosinophilic infiltration with flame figures. A distinctive tissue reaction seen in Wells’ syndrome and other diseases. Am J Dermatopathol. 1986;8(3):186–93.

    Article  CAS  PubMed  Google Scholar 

  113. Fisher GB, Greer KE, Cooper PH. Eosinophilic cellulitis (Wells’ syndrome). Int J Dermatol. 1985;24(2):101–7.

    Article  CAS  PubMed  Google Scholar 

  114. Garty BZ, Feinmesser M, David M, Gayer S, Danon YL. Congenital Wells syndrome. Pediatr Dermatol. 1997;14(4):312–5.

    Article  CAS  PubMed  Google Scholar 

  115. Anderson CR, Jenkins D, Tron V, Prendiville JS. Wells’ syndrome in childhood: case report and review of the literature. J Am Acad Dermatol. 1995;33(5 Pt 2):857–64.

    Article  CAS  PubMed  Google Scholar 

  116. Peters MS, Schroeter AL, Kephart GM, Gleich GJ. Localization of eosinophil granule major basic protein in chronic urticaria. J Invest Dermatol. 1983;81(1):39–43.

    Article  CAS  PubMed  Google Scholar 

  117. French LE, Shapiro M, Junkins-Hopkins JM, Wolfe JT, Rook AH. Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa. J Am Acad Dermatol. 2003;49(6):1170–4.

    Article  PubMed  Google Scholar 

  118. Honigsmann H. Polymorphous light eruption. Photodermatol Photoimmunol Photomed. 2008;24(3):155–61.

    Article  PubMed  Google Scholar 

  119. Epstein JH. Polymorphous light eruption. J Am Acad Dermatol. 1980;3(4):329–43.

    Article  CAS  PubMed  Google Scholar 

  120. Holzle E, Plewig G, von Kries R, Lehmann P. Polymorphous light eruption. J Invest Dermatol. 1987;88(3 Suppl):32s–8.

    Article  CAS  PubMed  Google Scholar 

  121. Hood AF, Elpern DJ, Morison WL. Histopathologic findings in papulovesicular light eruption. J Cutan Pathol. 1986;13(1):13–21.

    Article  CAS  PubMed  Google Scholar 

  122. Higgins CR, Wakeel RA, Cerio R. Childhood Jessner’s lymphocytic infiltrate of the skin. Br J Dermatol. 1994;131(1):99–101.

    Article  CAS  PubMed  Google Scholar 

  123. Lipsker D, Mitschler A, Grosshans E, Cribier B. Could Jessner’s lymphocytic infiltrate of the skin be a dermal variant of lupus erythematosus? An analysis of 210 cases. Dermatology. 2006;213(1):15–22.

    Article  PubMed  Google Scholar 

  124. Tomasini D, Mentzel T, Hantschke M, Cerri A, Paredes B, Rutten A, Scharer L, Kutzner H. Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner’s lymphocytic infiltrate of the skin and cutaneous lupus erythematosus. J Cutan Pathol. 2010;37(11):1132–9.

    Article  PubMed  Google Scholar 

  125. Rijlaarsdam JU, Nieboer C, de Vries E, Willemze R. Characterization of the dermal infiltrates in Jessner’s lymphocytic infiltrate of the skin, polymorphous light eruption and cutaneous lupus erythematosus: differential diagnostic and pathogenetic aspects. J Cutan Pathol. 1990;17(1):2–8.

    Article  CAS  PubMed  Google Scholar 

  126. Millard TP, Bataille V, Snieder H, Spector TD, McGregor JM. The heritability of polymorphic light eruption. J Invest Dermatol. 2000;115(3):467–70.

    Article  CAS  PubMed  Google Scholar 

  127. Stratigos AJ, Antoniou C, Katsambas AD. Polymorphous light eruption. J Eur Acad Dermatol Venereol. 2002;16(3):193–206.

    Article  CAS  PubMed  Google Scholar 

  128. Gonzalez-Amaro R, Baranda L, Salazar-Gonzalez JF, Abud-Mendoza C, Moncada B. Immune sensitization against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol. 1991;24(1):70–3.

    Article  CAS  PubMed  Google Scholar 

  129. Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinic aspects and pathogenesis. Dermatol Clin. 2014;32(3):315–34. viii.

    Article  CAS  PubMed  Google Scholar 

  130. Baby O. Polymorphous light eruption: is herpes virus the culprit? Photodermatol Photoimmunol Photomed. 2002;18(3):162.

    Article  PubMed  Google Scholar 

  131. McFadden JP, Norris PG, Cerio R, Orchard G, Hawk JL. Heat shock protein 65 immunoreactivity in experimentally induced polymorphic light eruption. Acta Derm Venereol. 1994;74(4):283–5.

    CAS  PubMed  Google Scholar 

  132. Norris PG, Morris J, McGibbon DM, Chu AC, Hawk JL. Polymorphic light eruption: an immunopathological study of evolving lesions. Br J Dermatol. 1989;120(2):173–83.

    Article  CAS  PubMed  Google Scholar 

  133. Cooper KD, Oberhelman L, Hamilton TA, Baadsgaard O, Terhune M, LeVee G, Anderson T, Koren H. UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci U S A. 1992;89(18):8497–501.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. De Fabo EC, Noonan FP. Mechanism of immune suppression by ultraviolet irradiation in vivo: I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med. 1983;158(1):84–98.

    Article  PubMed  Google Scholar 

  135. Kolgen W, van Meurs M, Jongsma M, van Weelden H, Bruijnzeel-Koomen CA, Knol EF, van Vloten WA, Laman J, de Gruijl FR. Differential expression of cytokines in UV-B-exposed skin of patients with polymorphous light eruption: correlation with Langerhans cell migration and immunosuppression. Arch Dermatol. 2004;140(3):295–302.

    Article  PubMed  Google Scholar 

  136. Welsh KM, Smoller BR, Holbrook KA, Johnston K. Restrictive dermopathy. Report of two affected siblings and a review of the literature. Arch Dermatol. 1992;128(2):228–31.

    Article  CAS  PubMed  Google Scholar 

  137. Hou JW, Mai CF. Restrictive dermopathy in two sisters. Chang Gung Med J. 2003;26(7):510–4.

    PubMed  Google Scholar 

  138. Khanna P, Opitz JM, Gilbert-Barness E. Restrictive dermopathy: report and review. Fetal Pediatr Pathol. 2008;27(2):105–18.

    Article  PubMed  Google Scholar 

  139. Moulson CL, Go G, Gardner JM, van der Wal AC, Smitt JH, van Hagen JM, Miner JH. Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. J Invest Dermatol. 2005;125(5):913–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Navarro CL, Cadinanos J, De Sandre-Giovannoli A, Bernard R, Courrier S, Boccaccio I, Boyer A, Kleijer WJ, Wagner A, Giuliano F, Beemer FA, Freije JM, Cau P, Hennekam RC, Lopez-Otin C, Badens C, Levy N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum Mol Genet. 2005;14(11):1503–13.

    Article  CAS  PubMed  Google Scholar 

  141. Navarro CL, Cau P, Levy N. Molecular bases of progeroid syndromes. Hum Mol Genet. 2006;15(Spec No 2):R151–161.

    Article  CAS  PubMed  Google Scholar 

  142. Navarro CL, De Sandre-Giovannoli A, Bernard R, Boccaccio I, Boyer A, Genevieve D, Hadj-Rabia S, Gaudy-Marqueste C, Smitt HS, Vabres P, Faivre L, Verloes A, Van Essen T, Flori E, Hennekam R, Beemer FA, Laurent N, Le Merrer M, Cau P, Levy N. Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. Hum Mol Genet. 2004;13(20):2493–503.

    Article  CAS  PubMed  Google Scholar 

  143. Youn GJ, Uzunyan M, Vachon L, Johnson J, Winder TL, Yano S. Autosomal recessive LMNA mutation causing restrictive dermopathy. Clin Genet. 2010;78(2):199–200.

    Article  CAS  PubMed  Google Scholar 

  144. Hozak P, Sasseville AM, Raymond Y, Cook PR. Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. J Cell Sci. 1995;108(Pt 2):635–44.

    CAS  PubMed  Google Scholar 

  145. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging. Nat Med. 2005;11(7):780–5.

    Article  CAS  PubMed  Google Scholar 

  146. Wiesel N, Mattout A, Melcer S, Melamed-Book N, Herrmann H, Medalia O, Aebi U, Gruenbaum Y. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proc Natl Acad Sci U S A. 2008;105(1):180–5.

    Article  CAS  PubMed  Google Scholar 

  147. Matuleviciene A, Meskiene R, Morkuniene A, Ambrozaityte L, Meskauskas R, Garunkstiene R, Drazdiene N, Utkus A, Kucinskas V. Frame shift mutations of the ZMPSTE24 gene in two siblings with restrictive dermopathy. Clin Dysmorphol. 2015;25(1):7–11.

    Article  Google Scholar 

  148. Musich PR, Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging (Albany, NY). 2009;1(1):28–37.

    Article  CAS  Google Scholar 

  149. Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH. Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates. Nucleus. 2015;6(3):236–46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  150. Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119(Pt 22):4644–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  151. Gonzalo S, Kreienkamp R. DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome. Curr Opin Cell Biol. 2015;34:75–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Jagadeesh S, Bhat L, Suresh I, Muralidhar SL. Prenatal diagnosis of restrictive dermopathy. Indian Pediatr. 2009;46(4):349–51.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology & Immunology, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA

    Thuy L. Phung MD, PhD

  2. Departments of Dermatology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA

    Teresa S. Wright MD

  3. Departments of Dermatology and Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA

    Crystal Y. Pourciau MD, MPH

  4. Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Bruce R. Smoller MD

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  1. Thuy L. Phung MD, PhD
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  3. Crystal Y. Pourciau MD, MPH
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  4. Bruce R. Smoller MD
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Phung, T.L., Wright, T.S., Pourciau, C.Y., Smoller, B.R. (2017). Dermatoses with Minimal Epidermal Changes. In: Pediatric Dermatopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-44824-4_5

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