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Regenerative Strategies for the Treatment of Knee Joint Disabilities pp 163–185Cite as

Rapid Prototyping for the Engineering of Osteochondral Tissues

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Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 21))

Abstract

The reconstruction of complex joints represents one of the major challenges in Tissue Engineering, whose aim is to realize bioactive 3D grafts interacting with the articular environment while providing structural and mechanical functionality. Due to the complex hierarchical structure and the co-existence of several architectural organizations of natural articular tissue, a series of chemical-physical-biological features have to be carefully controlled and defined for a best tuning of the mechanical and functional properties of osteochondral tissues. However, the control over scaffold architecture using conventional manufacturing techniques is highly process dependent rather than design dependent. As a result, in the last years Rapid Prototyping (RP) techniques are proposed as promising alternative for 3D porous scaffolds fabrication, opening the possibility to realize engineered grafts with defined and reproducible complex internal structures, for an enhanced cellular response in vivo; moreover, implantable personalized articular tissue materials may be created individually for each patient according to the orthopedic requirements. In this Chapter, we will expose the major RP-based techniques, among them laser-, nozzled- and printed-based RP methods, with particular reference to the most cogent works in the field of joints repair.

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Authors and Affiliations

  1. CNR—National Research Council of Italy, IEIIT Institute, Genoa, Italy

    Alessandra Marrella, Marta Cavo & Silvia Scaglione

  2. Department of Experimental Medicine, University of Genoa, Genoa, Italy

    Alessandra Marrella

  3. Department of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genoa, Genoa, Italy

    Marta Cavo

Authors
  1. Alessandra Marrella
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  2. Marta Cavo
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  3. Silvia Scaglione
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Corresponding author

Correspondence to Silvia Scaglione .

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Editors and Affiliations

  1. 3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães, Portugal

    Joaquim Miguel Oliveira

  2. ICVS/3B’s—PT Government Associate, Laboratory, University of Minho, Guimarães, Portugal

    Rui Luís Reis

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Marrella, A., Cavo, M., Scaglione, S. (2017). Rapid Prototyping for the Engineering of Osteochondral Tissues. In: Oliveira, J., Reis, R. (eds) Regenerative Strategies for the Treatment of Knee Joint Disabilities. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-319-44785-8_9

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