Abstract
The meniscus tissue has important roles in the function and biomechanics of the knee. Despite the great advances in the treatment of meniscus lesions, the clinical need is still not fulfilled. To overcome the challenges of regeneration, tissue engineering-based strategies have been attempted with limited success. The process of meniscus tissue regeneration is very complex and has many parameters that are evident only to a certain degree. Today, the regenerative strategies have been advancing beyond the traditional tissue engineering concept by growing the utilization of the expertises of complementary areas that include, but not limited to, bioreactor engineering, bioprinting coupled to reverse engineering, biology, nanotechnology and gene therapy approaches. Herein, the recent reported advanced strategies involving bioreactors, self-assembling process, and somatic gene therapy for meniscus regeneration are overviewed.
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References
Allen AA, Caldwell GL Jr, Fu FH (1995) Anatomy and biomechanics of the meniscus. Oper Tech Orthop 5(1):2–9
McDermott ID, Masouros SD, Amis AA (2008) Biomechanics of the menisci of the knee. Curr Orthop 22(3):193–201
Fetzer GB, Spindler KP, Amendola A, Andrish JT, Bergfeld JA, Dunn WR, Flanigan DC, Jones M, Kaeding CC, Marx RG (2009) Potential market for new meniscus repair strategies: evaluation of the MOON cohort. J Knee Surg 22(3):180
Tudor F, McDermott ID, Myers P (2014) Meniscal repair: a review of current practice. Orthop Trauma 28(2):88–96
Fairbank T (1948) Knee joint changes after meniscectomy. J Bone Joint Surg Br 30(4):664–670
McDermott I, Amis A (2006) The consequences of meniscectomy. J Bone Joint Surg Br 88(12):1549–1556
Mordecai SC, Al-Hadithy N, Ware HE, Gupte CM (2014) Treatment of meniscal tears: an evidence based approach. World J Orthop 5(3):233
Arnoczky SP, Warren RF (1982) Microvasculature of the human meniscus. Am J Sports Med 10(2):90–95
Makris EA, Hadidi P, Athanasiou KA (2011) The knee meniscus: structure–function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials 32(30):7411–7431
Scotti C, Hirschmann MT, Antinolfi P, Martin I, Peretti GM (2013) Meniscus repair and regeneration: review on current methods and research potential. Eur Cells Mater 26:150–170
Pereira H, Frias AM, Oliveira JM, Espregueira-Mendes J, Reis RL (2011) Tissue engineering and regenerative medicine strategies in meniscus lesions. Arthroscopy 27(12):1706–1719
Kang SW, Sun-Mi S, Jae-Sun L, Eung-Seok L, Kwon-Yong L, Sang-Guk P, Jung-Ho P, Byung-Soo K (2006) Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model. J Biomed Mater Res Part A 77(4):659–671
Zellner J, Mueller M, Berner A, Dienstknecht T, Kujat R, Nerlich M, Hennemann B, Koller M, Prantl L, Angele M (2010) Role of mesenchymal stem cells in tissue engineering of meniscus. J Biomed Mater Res Part A 94(4):1150–1161
Stone KR, Rodkey WG, Webber R, McKinney L, Steadman JR (1992) Meniscal regeneration with copolymeric collagen scaffolds in vitro and in vivo studies evaluated clinically, histologically, and biochemically. Am J Sports Med 20(2):104–111
Verdonk R, Verdonk P, Huysse W, Forsyth R, Heinrichs E-L (2011) Tissue ingrowth after implantation of a novel, biodegradable polyurethane scaffold for treatment of partial meniscal lesions. Am J Sports Med 39(4):774–782
Gu Y, Wang Y, Dai H, Lu L, Cheng Y, Zhu W (2012) Chondrogenic differentiation of canine myoblasts induced by cartilage-derived morphogenetic protein-2 and transforming growth factor-β1 in vitro. Mol Med Rep 5(3):767–772
Ishida K, Kuroda R, Miwa M, Tabata Y, Hokugo A, Kawamoto T, Sasaki K, Doita M, Kurosaka M (2007) The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng 13(5):1103–1112
Ballyns JJ, Wright TM, Bonassar LJ (2010) Effect of media mixing on ECM assembly and mechanical properties of anatomically-shaped tissue engineered meniscus. Biomaterials 31(26):6756–6763
Puetzer JL, Ballyns JJ, Bonassar LJ (2012) The effect of the duration of mechanical stimulation and post-stimulation culture on the structure and properties of dynamically compressed tissue-engineered menisci. Tissue Eng Part A 18(13–14):1365–1375
Liu C, Toma IC, Mastrogiacomo M, Krettek C, von Lewinski G, Jagodzinski M (2013) Meniscus reconstruction: today’s achievements and premises for the future. Arch Orthop Trauma Surg 133(1):95–109
Pereira H, Silva-Correia J, Oliveira J, Reis R, Espregueira-Mendes J (2013) Future trends in the treatment of meniscus lesions: from repair to regeneration. In: Verdonk R, Espregueira-Mendes J, Monllau JC (eds) Meniscal transplantation. Springer, Berlin, pp 103–112
Oliveira J, Pereira H, Yan L, Silva-Correia J, Oliveira A, Espregueira-Mendes J, Reis R (2013) Scaffold that enables segmental vascularization for the engineering of complex tissues and methods of making the same, PT Patent 106174, Priority date: 161/2013, 26-08-2013
Zhong J-J (2010) Recent advances in bioreactor engineering. Korean J Chem Eng 27(4):1035–1041
Wang D, Liu W, Han B, Xu R (2005) The bioreactor: a powerful tool for large-scale culture of animal cells. Curr Pharm Biotechnol 6(5):397–403
Hansmann J, Groeber F, Kahlig A, Kleinhans C, Walles H (2013) Bioreactors in tissue engineering—principles, applications and commercial constraints. Biotechnol J 8(3):298–307
Pörtner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM (2005) Bioreactor design for tissue engineering. J Biosci Bioeng 100(3):235–245
Martin Y, Vermette P (2005) Bioreactors for tissue mass culture: design, characterization, and recent advances. Biomaterials 26(35):7481–7503
Neves AA, Medcalf N, Brindle KM (2005) Influence of stirring-induced mixing on cell proliferation and extracellular matrix deposition in meniscal cartilage constructs based on polyethylene terephthalate scaffolds. Biomaterials 26(23):4828–4836
Neves AA, Medcalf N, Brindle K (2003) Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy. Tissue Eng 9(1):51–62
Marsano A, Wendt D, Quinn T, Sims T, Farhadi J, Jakob M, Heberer M, Martin I (2006) Bi-zonal cartilaginous tissues engineered in a rotary cell culture system. Biorheology 43(3):553–560
Petri M, Ufer K, Toma I, Becher C, Liodakis E, Brand S, Haas P, Liu C, Richter B, Haasper C (2012) Effects of perfusion and cyclic compression on in vitro tissue engineered meniscus implants. Knee Surg Sports Traumatol Arthrosc 20(2):223–231
Fox DB, Warnock JJ, Stoker AM, Luther JK, Cockrell M (2010) Effects of growth factors on equine synovial fibroblasts seeded on synthetic scaffolds for avascular meniscal tissue engineering. Res Vet Sci 88(2):326–332
Aufderheide AC, Athanasiou KA (2005) Comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus. Tissue Eng 11(7–8):1095–1104
Gunja NJ, Athanasiou KA (2010) Effects of hydrostatic pressure on leporine meniscus cell-seeded PLLA scaffolds. J Biomed Mater Res Part A 92(3):896–905
Gunja NJ, Uthamanthil RK, Athanasiou KA (2009) Effects of TGF-β1 and hydrostatic pressure on meniscus cell-seeded scaffolds. Biomaterials 30(4):565–573
Weinand C, Xu JW, Peretti GM, Bonassar LJ, Gill TJ (2009) Conditions affecting cell seeding onto three-dimensional scaffolds for cellular-based biodegradable implants. J Biomed Mater Res B Appl Biomater 91(1):80–87
McNulty AL, Estes BT, Wilusz RE, Weinberg JB, Guilak F (2010) Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1. Osteoarthr Cartil 18(6):830–838
Ballyns JJ, Bonassar LJ (2011) Dynamic compressive loading of image-guided tissue engineered meniscal constructs. J Biomech 44(3):509–516
Martínez H, Brackmann C, Enejder A, Gatenholm P (2012) Mechanical stimulation of fibroblasts in micro-channeled bacterial cellulose scaffolds enhances production of oriented collagen fibers. J Biomed Mater Res Part A 100(4):948–957
Liu C, Abedian R, Meister R, Haasper C, Hurschler C, Krettek C, von Lewinski G, Jagodzinski M (2012) Influence of perfusion and compression on the proliferation and differentiation of bone mesenchymal stromal cells seeded on polyurethane scaffolds. Biomaterials 33(4):1052–1064
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG, Levenston ME (2010) Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs. Tissue Eng Part A 16(6):1913–1923
Upton ML, Chen J, Guilak F, Setton LA (2003) Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res 21(6):963–969
Ferretti M, Madhavan S, Deschner J, Rath-Deschner B, Wypasek E, Agarwal S (2006) Dynamic biophysical strain modulates proinflammatory gene induction in meniscal fibrochondrocytes. Am J Physiol Cell Physiol 290(6):C1610–C1615
Pereira H, Caridade SG, Frias AM, Silva-Correia J, Pereira DR, Cengiz IF, Mano JF, Oliveira JM, Espregueira-Mendes J, Reis RL (2014) Biomechanical and cellular segmental characterization of human meniscus: building the basis for tissue engineering therapies. Osteoarthr Cartil 22(9):1271–1281
Athanasiou KA, Eswaramoorthy R, Hadidi P, Hu JC (2013) Self-organization and the self-assembling process in tissue engineering. Annu Rev Biomed Eng 15:115–136
Hu JC, Athanasiou KA (2006) A self-assembling process in articular cartilage tissue engineering. Tissue Eng 12(4):969–979
Araujo V, Figueiredo C, Joazeiro P, Mora O, Toledo O (2002) In vitro rapid organization of rabbit meniscus fibrochondrocytes into chondro-like tissue structures. J Submicrosc Cytol Pathol 34(3):335–343
Hoben GM, Athanasiou KA (2008) Creating a spectrum of fibrocartilages through different cell sources and biochemical stimuli. Biotechnol Bioeng 100(3):587–598
Hoben GM, Hu JC, James RA, Athanasiou KA (2007) Self-assembly of fibrochondrocytes and chondrocytes for tissue engineering of the knee meniscus. Tissue Eng 13(5):939–946
Aufderheide AC, Athanasiou KA (2007) Assessment of a bovine co-culture, scaffold-free method for growing meniscus-shaped constructs. Tissue Eng 13(9):2195–2205
MacBarb RF, Makris EA, Hu JC, Athanasiou KA (2013) A chondroitinase-ABC and TGF-β1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage. Acta Biomater 9(1):4626–4634
Huey DJ, Athanasiou KA (2011) Tension-compression loading with chemical stimulation results in additive increases to functional properties of anatomic meniscal constructs. PLoS ONE 6(11):e27857
Huey DJ, Athanasiou KA (2011) Maturational growth of self-assembled, functional menisci as a result of TGF-β1 and enzymatic chondroitinase-ABC stimulation. Biomaterials 32(8):2052–2058
Adachi N, Pelinkovic D, Lee CW, Fu FH, Huard J (2001) Gene therapy and the future of cartilage repair. Oper Tech Orthop 11(2):138–144
Chen Y (2001) Orthopedic applications of gene therapy. J Orthop Sci 6(2):199–207
Evans C (1995) Current concepts review: possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 77(7):1103–1114
Evans C, Ghivizzani S, Robbins P (2012) Orthopedic gene therapy—lost in translation? J Cell Physiol 227(2):416–420
Evans C, Ghivizzani S, Smith P, Shuler F, Mi Z, Robbins P (2000) Using gene therapy to protect and restore cartilage. Clin Orthop Rel Res (379 Suppl):S214
Giannoudis PV, Tzioupis CC, Tsirids E (2006) Gene therapy in orthopaedics. Injury 37(1):S30–S40
Anderson WF (1998) Human gene therapy. Nature 392(6679):25
Kaufmann KB, Büning H, Galy A, Schambach A, Grez M (2013) Gene therapy on the move. EMBO Mol Med 5(11):1642–1661
Babensee JE, McIntire LV, Mikos AG (2000) Growth factor delivery for tissue engineering. Pharm Res 17(5):497–504
Nimni M (1997) Polypeptide growth factors: targeted delivery systems. Biomaterials 18(18):1201–1225
Bhargava MM, Attia ET, Murrell GA, Dolan MM, Warren RF, Hannafin JA (1999) The effect of cytokines on the proliferation and migration of bovine meniscal cells. Am J Sports Med 27(5):636–643
Kasemkijwattana C, Menetrey J, Goto H, Niyibizi C, Fu FH, Huard J (2000) The use of growth factors, gene therapy and tissue engineering to improve meniscal healing. Mater Sci Eng C 13(1):19–28
Musumeci G, Loreto C, Carnazza ML, Cardile V, Leonardi R (2012) Acute injury affects lubricin expression in knee menisci. An immunohistochemical study. Ann Anatomy Anat Anz 95(2):151–158
Jones A, Flannery C (2007) Bioregulation of lubricin expression by growth factors and cytokines. Eur Cells Mater 13:40
Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F (2007) Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. Osteoarthr Cartil 15(9):1053–1060
Goto H, Shuler FD, Lamsam C, Moller HD, Niyibizi C, Fu FH, Robbins PD, Evans CH (1999) Transfer of LacZ marker gene to the meniscus. J Bone Joint Surg 81(7):918–925
Madry H, Cucchiarini M, Kaul G, Kohn D, Terwilliger EF, Trippel SB (2004) Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo. Am J Sports Med 32(8):1860–1865
Cucchiarini M, Schetting S, Terwilliger E, Kohn D, Madry H (2009) rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and α-SMA expression in human meniscal lesions. Gene Ther 16(11):1363–1372
Hidaka C, Ibarra C, Hannafin JA, Torzilli PA, Quitoriano M, Jen S-S, Warren RF, Crystal RG (2002) Formation of vascularized meniscal tissue by combining gene therapy with tissue engineering. Tissue Eng 8(1):93–105
Martinek V, Usas A, Pelinkovic D, Robbins P, Fu FH, Huard J (2002) Genetic engineering of meniscal allografts. Tissue Eng 8(1):107–117
Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH (2007) Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-β1 complementary deoxyribonucleic acid. Tissue Eng 13(9):2227–2237
Bonadio J (2000) Tissue engineering via local gene delivery. J Mol Med 78(6):303–311
Goto H, Shuler F, Niyibizi C, Fu F, Robbins P, Evans C (2000) Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFβ1 gene. Osteoarthr Cartil 8(4):266–271
Zhang H, Leng P, Zhang J (2009) Enhanced meniscal repair by overexpression of hIGF-1 in a full-thickness model. Clin Orthop Relat Res 467(12):3165–3174
Acknowledgments
The authors thank to the financial support of the MultiScaleHuman project (Contract number: MRTN-CT-2011-289897) in the Marie Curie Actions—Initial Training Networks. I. F. Cengiz thanks the Portuguese Foundation for Science and Technology (FCT) for the Ph.D. scholarship (SFRH/BD/99555/2014). J. M. Oliveira also thanks to the FCT for the funds provided to under the program Investigador FCT 2012 (IF/00423/2012).
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Cengiz, I.F., Silva-Correia, J., Pereira, H., Espregueira-Mendes, J., Oliveira, J.M., Reis, R.L. (2017). Advanced Regenerative Strategies for Human Knee Meniscus. In: Oliveira, J., Reis, R. (eds) Regenerative Strategies for the Treatment of Knee Joint Disabilities. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-319-44785-8_14
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