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Stress Response Pathways

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Ageing: Lessons from C. elegans

Part of the book series: Healthy Ageing and Longevity ((HAL))

Abstract

Physiological stress occurs when conditions perturb homeostasis. There are a multitude of stressors commonly encountered by organisms, including environmental factors such as temperature, pathogens, toxins, and food or oxygen availability, or internal disturbances caused by genetic defects or damage accumulated over the course of ageing. In this chapter, we discuss the fundamental relationships between stress and homeostasis. We then focus on various stress response strategies and highlight established molecular genetic stress response pathways. Many experiments, particularly those in C. elegans, have highlighted the intimate relationship between stress resistance and longevity. As such, a deeper understanding of the fundamental nature of stress and homeostatic stress responses is essential to fully appreciate the causes and consequences of ageing in animals.

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  1. Department Biochemistry, University of Washington School of Medicine, Seattle, WA, USA

    Dana L. Miller, Joseph Horsman & Frazer I. Heinis

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    Matthew S. Gill

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Miller, D.L., Horsman, J., Heinis, F.I. (2017). Stress Response Pathways. In: Olsen, A., Gill, M. (eds) Ageing: Lessons from C. elegans. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-44703-2_9

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