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Integration of Metabolic Signals

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Book cover Ageing: Lessons from C. elegans

Part of the book series: Healthy Ageing and Longevity ((HAL))

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Abstract

Over the last 25 years it has become evident that single gene mutations can result in remarkable increases in lifespan. Of the gene mutations identified, the most potent at extending life- and healthspan are those that alter the quantity of food ingested (Avery, Genetics 133 (4):897–917, 1993) and those that disrupt the animals perception of the amount of food ingested (Gottlieb and Ruvkun, Genetics 137 (1):107–120, 1994; Dorman et al, Genetics 141 (4):1399–1406, 1995; Kimura et al, Science 277(5328):942–946, 1997; Lee et al, Curr Biol 11 (24):1950–1957, 2001). These mutations promote longevity, animal health and capacity for stress adaptation (Honda and Honda, Faseb J 13 (11):1385–1393, 1999; Scott et al, Science 296 (5577):2388–2391, 2002; Garsin et al, Science 300 (5627):1921, 2003; Lithgow and Kirkwood, Science 273 (5271):80, 1996), but importantly reveal that an intricate molecular and genetic network exists to integrate diet availability, utilization and animal physiology (Curran and Ruvkun, PLoS Genet 3 (4):e56. doi:10.1371/journal.pgen.0030056, 2007; Dillin et al, Science 298 (5602):2398–2401. doi:10.1126/science.1077780, 2002; Hamilton et al. Genes Dev 19 (13):1544–1555, 2005; Hansen et al, PLoS Genet 1 (1):e17, 2005; Lee et al, Nat Genet 33 (1):40–48, 2003; Tacutu et al, PLoS ONE 7 (10):e48282. doi:10.1371/journal.pone.0048282, 2012).

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  1. Davis School of Gerontology & Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA

    Dana A. Lynn & Sean P. Curran

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  1. Dana A. Lynn
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  1. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Anders Olsen

  2. Department of Metabolics & Aging, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, USA

    Matthew S. Gill

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Lynn, D.A., Curran, S.P. (2017). Integration of Metabolic Signals. In: Olsen, A., Gill, M. (eds) Ageing: Lessons from C. elegans. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-44703-2_17

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