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Oxidative Stress

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Ageing: Lessons from C. elegans

Part of the book series: Healthy Ageing and Longevity ((HAL))

Abstract

The oxidative damage theory has been the dominant paradigm in ageing research over the last 50 years. The versatile genetic nematode model C. elegans has been used by many to put this theory to the test. C. elegans is an attractive model as it ages fast, it has an elaborate antioxidant system which can be easily manipulated, and many long-lived mutants are available. Recently, it became possible to visualize reactive oxygen species (ROS) in vivo and in real-time in this transparent animal by using genetically encoded biosensors. The data generated in C. elegans to test the oxidative damage theory is often ambiguous and of mere correlative nature. Experimental manipulation of the antioxidant system most often disproves this theory. Over the years, it became clear that ROS, when present at normal physiological levels, are important signalling molecules. Interference with this ROS signal may elicit a cytoprotective programme that, in many cases, extends lifespan. It is still an open question whether the molecular underpinnings of this hormetic response is also of importance to the normal ageing process. Alternatives to the oxidative damage theory, such as the hypertrophy hypothesis, are currently gaining wider attention.

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  1. Biology Department, Ghent University, Proeftuinstraat 86 N1, 9000, Ghent, Belgium

    Bart P. Braeckman, Patricia Back & Filip Matthijssens

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  2. Department of Metabolics & Aging, The Scripps Research Institute - Scripps Florida, Jupiter, Florida, USA

    Matthew S. Gill

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Braeckman, B.P., Back, P., Matthijssens, F. (2017). Oxidative Stress. In: Olsen, A., Gill, M. (eds) Ageing: Lessons from C. elegans. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-44703-2_10

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