Abstract
The care of children with congenital heart disease is complex. In addition to considering intricate intracardiac anatomy, these children present with secondary issues that are either a result of their intracardiac pathology (liver failure from a failed Fontan palliation) or the management of this pathology. Persistent pain after sternotomy or thoracotomy is an underappreciated result of the latter. The little evidence available demonstrates that post-sternotomy pain may be 20 % 4 years after surgery in children, and post-thoracotomy pain between 1.96 and 16 %. There are distinct pathophysiologic mechanisms that distinguish this pain from acute postoperative pain, and proper management requires recognition and possible referral to a multidisciplinary pain clinic.
As with chronic postoperative pain after cardiothoracic surgery, the use of regional anesthetic techniques is underappreciated in patients with congenital heart disease. With the use of ultrasound, these nerve blocks are safe and particularly useful in those children that may not tolerate general anesthesia. Neuraxial blocks, paravertebral nerve blocks, Pecs and serratus plane blocks, as well as transversus abdominis plane blocks are a group of peripheral blocks that can be used for a variety of thoracic, abdominal, and lower extremity procedures in pediatric patients with congenital heart disease presenting for noncardiac surgery.
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References
Anand KJ, Hansen DD, Hickey PR. Hormonal-metabolic stress responses in neonates undergoing cardiac surgery. Anesthesiology. 1990;73:661–70.
Anand KJ, Hickey PR. Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. N Engl J Med. 1992;326:1–9.
Andreae MH, Andreae DA. Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery. Cochrane Database Syst Rev. 2012;10:CD007105.
Andreae MH, Andreae DA. Regional anaesthesia to prevent chronic pain after surgery: a Cochrane systematic review and meta-analysis. Br J Anaesth. 2013;111:711–20.
Bashandy GM, Abbas DN. Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial. Reg Anesth Pain Med. 2015;40:68–74.
Ben-Ari A, Moreno M, Chelly JE, Bigeleisen PE. Ultrasound-guided paravertebral block using an intercostal approach. Anesth Analg. 2009;109:1691–4.
Benedetti F, Vighetti S, Ricco C, Amanzio M, Bergamasco L, Casadio C, Cianci R, Giobbe R, Oliaro A, Bergamasco B, Maggi G. Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy. J Thorac Cardiovasc Surg. 1998;115:841–7.
Blanco R. The ‘pecs block’: a novel technique for providing analgesia after breast surgery. Anaesthesia. 2011;66:847–8.
Blanco R. A reply. Anaesthesia. 2014;69:1173–4.
Blanco R, Fajardo M, Parras Maldonado T. Ultrasound description of Pecs II (modified Pecs I): a novel approach to breast surgery. Rev Esp Anestesiol Reanim. 2012;59:470–5.
Blanco R, Parras T, McDonnell JG, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013;68:1107–13.
Boretsky K, Visoiu M, Bigeleisen P. Ultrasound-guided approach to the paravertebral space for catheter insertion in infants and children. Paediatr Anaesth. 2013;23:1193–8.
Boretsky KR. Regional anesthesia in pediatrics: marching forward. Curr Opin Anaesthesiol. 2014;27:556–60.
Bruce J, Drury N, Poobalan SA, Jeffrey RR, Smith SWC, Chambers AW. The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study. Pain. 2003;104:265–73.
Bryskin RB, Londergan B, Wheatley R, Heng R, Lewis M, Barraza M, Mercer E, Ye G. Transversus abdominis plane block versus caudal epidural for lower abdominal surgery in children: a double-blinded randomized controlled trial. Anesth Analg. 2015;121:471–8.
Casati A, Alessandrini P, Nuzzi M, Tosi M, Iotti E, Ampollini L, Bobbio A, Rossini E, Fanelli G. A prospective, randomized, blinded comparison between continuous thoracic paravertebral and epidural infusion of 0.2% ropivacaine after lung resection surgery. Eur J Anaesthesiol. 2006;23:999–1004.
Chaney MA. Thoracic epidural anaesthesia in cardiac surgery – the current standing. Ann Card Anaesth. 2009;12:1–3.
Chou J, Chan C-w, Chalkiadis GA. Post-thoracotomy pain in children and adolescence: a retrospective cross-sectional study. Pain Med. 2014;15:452–9.
Cohen LL, Lemanek K, Blount RL, Dahlquist LM, Lim CS, Palermo TM, McKenna KD, Weiss KE. Evidence-based assessment of pediatric pain. J Pediatr Psychol. 2008;33:939–55; discussion 956–937.
Eisenberg E, Pultorak Y, Pud D, Bar-El Y. Prevalence and characteristics of post coronary artery bypass graft surgery pain (PCP). Pain. 2001;92:11–7.
Faasse MA, Lindgren BW, Frainey BT, Marcus CR, Szczodry DM, Glaser AP, Suresh S, Gong EM. Perioperative effects of caudal and transversus abdominis plane (TAP) blocks for children undergoing urologic robot-assisted laparoscopic surgery. J Pediatr Urol. 2015;11:121.e121-127.
Farooq M, Carey M. A case of liver trauma with a blunt regional anesthesia needle while performing transversus abdominis plane block. Reg Anesth Pain Med. 2008;33:274–5.
Finkel JC, Boltz MG, Conran AM. Haemodynamic changes during high spinal anaesthesia in children having open heart surgery. Paediatr Anaesth. 2003;13:48–52.
Fishman S, Ballantyne J, Rathmell JP, Bonica J. Bonica’s management of pain. 4th ed. Baltimore: Lippincott Williams & Wilkins; 2010.
Fong J, Druzin M, Gimbel AA, Fisher J. Epidural anaesthesia for labour and caesarean section in a parturient with a single ventricle and transposition of the great arteries. Can J Anaesth. 1990;37:680–4.
Fujiwara A, Komasawa N, Minami T. Pectoral nerves (PECS) and intercostal nerve block for cardiac resynchronization therapy device implantation. Springerplus. 2014;3:409.
Gerner P. Postthoracotomy pain management problems. Anesthesiol Clin. 2008;26:355–67, vii.
Giesecke K, Hamberger B, Järnberg PO, Klingstedt C. Paravertebral block during cholecystectomy: effects on circulatory and hormonal responses. Br J Anaesth. 1988;61:652–6.
Gonzalez KW, Dalton BG, Millspaugh DL, Thomas PG, St Peter SD. Epidural versus patient-controlled analgesia after pediatric thoracotomy for malignancy: a preliminary review. Eur J Pediatr Surg. 2015;26:340–3.
Gottlieb EA, Andropoulos DB. Anesthesia for the patient with congenital heart disease presenting for noncardiac surgery. Curr Opin Anaesthesiol. 2013;26:318–26.
Hall Burton DM, Boretsky KR. A comparison of paravertebral nerve block catheters and thoracic epidural catheters for postoperative analgesia following the Nuss procedure for pectus excavatum repair. Paediatr Anaesth. 2014;24:516–20.
Hamill JK, Rahiri J-L, Liley A, Hill AG. Rectus sheath and transversus abdominis plane blocks in children: a systematic review and meta-analysis of randomized trials. Paediatr Anaesth. 2016;26:363–71.
Hammer GB, Ngo K, Macario A. A retrospective examination of regional plus general anesthesia in children undergoing open heart surgery. Anesth Analg. 2000;90:1020–4.
Hardacker DM, Tolley JA. Postoperative neuraxial pain relief in the pediatric patient. Semin Pediatr Surg. 2004;13:203–9.
Harnik EV, Hoy GR, Potolicchio S, Stewart DR, Siegelman RE. Spinal anesthesia in premature infants recovering from respiratory distress syndrome. Anesthesiology. 1986;64:95–9.
Ing RJ, Twite MD. The year in review: anesthesia for congenital heart disease 2014. Semin Cardiothorac Vasc Anesth. 2015;19:12–20.
Ivani G, Mosseti V. Pediatric regional anesthesia. Minerva Anestesiol. 2009;75:577–83.
Johnston MV. Plasticity in the developing brain: implications for rehabilitation. Dev Disabil Res Rev. 2009;15:94–101.
Kachko L, Birk E, Simhi E, Tzeitlin E, Freud E, Katz J. Spinal anesthesia for noncardiac surgery in infants with congenital heart diseases. Paediatr Anaesth. 2012;22:647–53.
Karmakar MK, Booker PD, Franks R, Pozzi M. Continuous extrapleural paravertebral infusion of bupivacaine for post-thoracotomy analgesia in young infants. Br J Anaesth. 1996;76:811–5.
Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618–25.
Kristensen AD, Pedersen TAL, Hjortdal VE, Jensen TS, Nikolajsen L. Chronic pain in adults after thoracotomy in childhood or youth. Br J Anaesth. 2010;104:75–9.
Lahtinen P, Kokki H, Hynynen M. Pain after cardiac surgery: a prospective cohort study of 1-year incidence and intensity. Anesthesiology. 2006;105:794–800.
Lapmahapaisan S, Tantemsapya N, Aroonpruksakul N, Maisat W, Suraseranivongse S. Efficacy of surgical transversus abdominis plane block for postoperative pain relief following abdominal surgery in pediatric patients. Paediatr Anaesth. 2015;25:614–20.
Lauridsen MH, Kristensen AD, Hjortdal VE, Jensen TS, Nikolajsen L. Chronic pain in children after cardiac surgery via sternotomy. Cardiol Young. 2014;24:893–9.
Laussen PC, Bichell DP, McGowan FX, Zurakowski D, DeMaso DR, del Nido PJ. Postoperative recovery in children after minimum versus full-length sternotomy. Ann Thorac Surg. 2000;69:591–6.
Lockhart EM, Penning DH, Olufolabi AJ, Bell EA, Booth JV, Kern FH. SvO2 monitoring during spinal anesthesia and cesarean section in a parturient with severe cyanotic congenital heart disease. Anesthesiology. 1999;90:1213–5.
Long JB, Birmingham PK, De Oliveira GS, Schaldenbrand KM, Suresh S. Transversus abdominis plane block in children: a multicenter safety analysis of 1994 cases from the PRAN (Pediatric Regional Anesthesia Network) database. Anesth Analg. 2014;119:395–9.
Lönnqvist PA. Continuous paravertebral block in children. Initial experience. Anaesthesia. 1992;47:607–9.
Lorenzo AJ, Lynch J, Matava C, El-Beheiry H, Hayes J. Ultrasound guided transversus abdominis plane vs surgeon administered intraoperative regional field infiltration with bupivacaine for early postoperative pain control in children undergoing open pyeloplasty. J Urol. 2014;192:207–13.
Mai CL, Young MJ, Quraishi SA. Clinical implications of the transversus abdominis plane block in pediatric anesthesia. Paediatr Anaesth. 2012;22(9):831–40.
Matsunaga M, Dan K, Manabe FY, Hara F, Shono S, Shirakusa T. Residual pain of 90 thoracotomy patients with malignancy and non-malignancy. Pain. 1990;41 Suppl 5:s148.
Maxwell BG, El-Sayed YY, Riley ET, Carvalho B. Peripartum outcomes and anaesthetic management of parturients with moderate to complex congenital heart disease or pulmonary hypertension*. Anaesthesia. 2013;68:52–9.
McDonnell JG, O’Donnell B, Curley G, Heffernan A, Power C, Laffey JG. The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesth Analg. 2007;104:193–7.
Merskey H. Comments on Woolf et al. Pain 77(1998):227–9. Re: mechanisms and the classification of pain. Pain. 1999;82:319–20.
Merskey H, Bogduk N. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. 2nd ed. Seattle: IASP Press; 1994.
Meyer MJ, Krane EJ, Goldschneider KR, Klein NJ. Case report: neurological complications associated with epidural analgesia in children: a report of 4 cases of ambiguous etiologies. Anesth Analg. 2012;115:1365–70.
Meyerson J, Thelin S, Gordh T, Karlsten R. The incidence of chronic post-sternotomy pain after cardiac surgery – a prospective study. Acta Anaesthesiol Scand. 2001;45:940–4.
Murat I, Delleur MM, Esteve C, Egu JF, Raynaud P, Saint-Maurice C. Continuous extradural anaesthesia in children. Clinical and haemodynamic implications. Br J Anaesth. 1987;59:1441–50.
Naja Z, Lönnqvist PA. Somatic paravertebral nerve blockade. Incidence of failed block and complications. Anaesthesia. 2001;56:1184–8.
O Riain SC, Donnell BO, Cuffe T, Harmon DC, Fraher JP, Shorten G. Thoracic paravertebral block using real-time ultrasound guidance. Anesth Analg. 2010;110:248–51.
Oliver J-A, Oliver L-A. Beyond the caudal: truncal blocks an alternative option for analgesia in pediatric surgical patients. Curr Opin Anaesthesiol. 2013;26:644–51.
Peng TC, Chuah EC, Tan PP. Epidural anesthesia for emergency caesarean section in a patient with single ventricle and aortic stenosis. Acta Anaesthesiol Sin. 1997;35:39–44.
Peterson KL, DeCampli WM, Pike NA, Robbins RC, Reitz BA. A report of two hundred twenty cases of regional anesthesia in pediatric cardiac surgery. Anesth Analg. 2000;90:1014–9.
Pintaric TS, Potocnik I, Hadzic A, Stupnik T, Pintaric M, Novak Jankovic V. Comparison of continuous thoracic epidural with paravertebral block on perioperative analgesia and hemodynamic stability in patients having open lung surgery. Reg Anesth Pain Med. 2011;36:256–60.
Pluijms WA, Steegers MAH, Verhagen AFTM, Scheffer GJ, Wilder-Smith OHG. Chronic post-thoracotomy pain: a retrospective study. Acta Anaesthesiol Scand. 2006;50:804–8.
Polaner DM, Taenzer AH, Walker BJ, Bosenberg A, Krane EJ, Suresh S, Wolf C, Martin LD. Pediatric Regional Anesthesia Network (PRAN): a multi-institutional study of the use and incidence of complications of pediatric regional anesthesia. Anesth Analg. 2012;115:1353–64.
Ponn RB, Ferneini A, D’Agostino RS, Toole AL, Stern H. Comparison of late pulmonary function after posterolateral and muscle-sparing thoracotomy. Ann Thorac Surg. 1992;53:675–9.
Purcell N, Wu D. Novel use of the PECS II block for upper limb fistula surgery. Anaesthesia. 2014;69:1294.
Qi J, Du B, Gurnaney H, Lu P, Zuo Y. A prospective randomized observer-blinded study to assess postoperative analgesia provided by an ultrasound-guided bilateral thoracic paravertebral block for children undergoing the Nuss procedure. Reg Anesth Pain Med. 2014;39:208–13.
Rabbitts JA, Palermo TM, Zhou C, Mangione-Smith R. Pain and health-related quality of life after pediatric inpatient surgery. J Pain. 2015a;16:1334–41.
Rabbitts JA, Zhou C, Groenewald CB, Durkin L, Palermo TM. Trajectories of postsurgical pain in children: risk factors and impact of late pain recovery on long-term health outcomes after major surgery. Pain. 2015b;156:2383–9.
Richardson J, Lönnqvist PA. Thoracic paravertebral block. Br J Anaesth. 1998;81:230–8.
Richardson J, Sabanathan S, Jones J, Shah RD, Cheema S, Mearns AJ. A prospective, randomized comparison of preoperative and continuous balanced epidural or paravertebral bupivacaine on post-thoracotomy pain, pulmonary function and stress responses. Br J Anaesth. 1999;83:387–92.
Rodriguez-Aldrete D, Candiotti KA, Janakiraman R, Rodriguez-Blanco YF. Trends and New evidence in the management of acute and chronic post-thoracotomy pain-an overview of the literature from 2005 to 2015. J Cardiothorac Vasc Anesth. 2015;30:762–72.
Rozen WM, Tran TMN, Ashton MW, Barrington MJ, Ivanusic JJ, Taylor GI. Refining the course of the thoracolumbar nerves: a new understanding of the innervation of the anterior abdominal wall. Clin Anat. 2008;21:325–33.
Searle RD, Simpson MP, Simpson KH, Milton R, Bennett MI. Can chronic neuropathic pain following thoracic surgery be predicted during the postoperative period? Interact Cardiovasc Thorac Surg. 2009;9:999–1002.
Shah R, Sabanathan S, Richardson J, Mearns A, Bembridge J. Continuous paravertebral block for post thoracotomy analgesia in children. J Cardiovasc Surg (Torino). 1997;38:543–6.
Shenkman Z, Johnson VM, Zurakowski D, Arnon S, Sethna NF. Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction. Paediatr Anaesth. 2012;22:865–70.
Shima T, Momose K, Tokutomi S, Satoh K, Hashimoto Y. Postoperative analgesic requirements after various operations. Masui. 1996;45:370–3.
Slinger P, Shennib H, Wilson S. Postthoracotomy pulmonary function: a comparison of epidural versus intravenous meperidine infusions. J Cardiothorac Vasc Anesth. 1995;9:128–34.
Steegers MAH, Snik DM, Verhagen AF, van der Drift MA, Wilder-Smith OHG. Only half of the chronic pain after thoracic surgery shows a neuropathic component. J Pain. 2008;9:955–61.
Steven JM, McGowan FX. Neuraxial blockade for pediatric cardiac surgery: lessons yet to be learned. Anesth Analg. 2000;90:1011–3.
Støving K, Rothe C, Rosenstock CV, Aasvang EK, Lundstrøm LH, Lange KHW. Cutaneous sensory block area, muscle-relaxing effect, and block duration of the transversus abdominis plane block: a randomized, blinded, and placebo-controlled study in healthy volunteers. Reg Anesth Pain Med. 2015;40:355–62.
Steffel L, Kim TE, Howard SK, Ly DP, Kou A, King R, Mariano ER. Comparative Effectiveness of Two Ultrasound-Guided Regional Block Techniques for Surgical Anesthesia in Open Unilateral Inguinal Hernia Repair. J Ultrasound Med. 2016;35(1):177–82.
Suresh S, Taylor LJ, De Oliveira GS. Dose effect of local anesthetics on analgesic outcomes for the transversus abdominis plane (TAP) block in children: a randomized, double-blinded, clinical trial. Paediatr Anaesth. 2015;25:506–10.
Tan YR, Quek KHY. Tackling the axillary blind spot with PECS II. Anaesthesia. 2015;70:230–1.
van Gulik L, Janssen LI, Ahlers SJGM, Bruins P, Driessen AHG, van Boven WJ, van Dongen EPA, Knibbe CAJ. Risk factors for chronic thoracic pain after cardiac surgery via sternotomy. Eur J Cardiothorac Surg. 2011;40:1309–13.
Weiner MM, Rosenblatt MA, Mittnacht AJC. Neuraxial anesthesia and timing of heparin administration in patients undergoing surgery for congenital heart disease using cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2012;26:581–4.
Wildgaard K, Ravn J, Kehlet H. Chronic post-thoracotomy pain: a critical review of pathogenic mechanisms and strategies for prevention. Eur J Cardiothorac Surg. 2009;36:170–80.
Wolf AR, Doyle E, Thomas E. Modifying infant stress responses to major surgery: spinal vs extradural vs opioid analgesia. Paediatr Anaesth. 1998;8:305–11.
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Monico, E.C., Quiñónez, Z.A. (2017). Perioperative Pain Management in Patients with Congenital Heart Disease. In: Dabbagh, A., Conte, A., Lubin, L. (eds) Congenital Heart Disease in Pediatric and Adult Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-44691-2_39
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