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Myocardial Viability and Imaging in the Failing Heart

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Congestive Heart Failure and Cardiac Transplantation

Abstract

Patients with ischemic cardiomyopathy experience impaired left ventricular function, a major contributor to the morbidity and mortality related to heart failure. Yet left ventricular dysfunction in many patients with myocardial stunning or hibernation may be reversible. When viable myocardium is present, coronary revascularization can lead to functional recovery, improvement in symptoms, and prognosis. Knowing which patients will benefit from revascularization is, obviously, clinically important. Clinicians have a range of diagnostic testing options that identify the presence or absence of viable myocardium. This chapter describes the available viability testing options in detail, including their benefits and limitations. These testing options include echocardiography, dobutamine stress echocardiography, single-photon emission computed tomography (SPECT), positron emission tomography (PET), cardiac computed tomography (CCT) imaging, and the current gold standard of delayed-enhancement cardiac magnetic resonance imaging (DE-CMR). The value of myocardial viability testing in predicting outcomes after revascularization has also been evaluated in many small single-center studies—and looks promising—but needs continued research.

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References

  1. Camici PG, Prasad SK, Rimoldi OE. Stunning, hibernation, and assessment of myocardial viability. Circulation. 2008;117(1):103–14. doi:10.1161/CIRCULATIONAHA.107.702993.

    Article  PubMed  Google Scholar 

  2. Pellikka PA, Nagueh SF, Elhendy AA, Kuehl CA, Sawada SG, American Society of Echocardiography. American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography. J Am Soc Echocardiogr. 2007;20(9):1021–41. doi:10.1016/j.echo.2007.07.003.

    Article  PubMed  Google Scholar 

  3. La Canna G, Alfieri O, Giubbini R, Gargano M, Ferrari R, Visioli O. Echocardiography during infusion of dobutamine for identification of reversibly dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol. 1994;23(3):617–26.

    Article  PubMed  Google Scholar 

  4. Senior R, Lahiri A. Role of dobutamine echocardiography in detection of myocardial viability for predicting outcome after revascularization in ischemic cardiomyopathy. J Am Soc Echocardiogr. 2001;14(3):240–8.

    Article  CAS  PubMed  Google Scholar 

  5. Sun KT, Czernin J, Krivokapich J, Lau YK, Bottcher M, Maurer G, Phelps ME, Schelbert HR. Effects of dobutamine stimulation on myocardial blood flow, glucose metabolism, and wall motion in normal and dysfunctional myocardium. Circulation. 1996;94(12):3146–54.

    Article  CAS  PubMed  Google Scholar 

  6. Krivokapich J, Czernin J, Schelbert HR. Dobutamine positron emission tomography: absolute quantitation of rest and dobutamine myocardial blood flow and correlation with cardiac work and percent diameter stenosis in patients with and without coronary artery disease. J Am Coll Cardiol. 1996;28(3):565–72.

    Article  CAS  PubMed  Google Scholar 

  7. Kaul S. Myocardial contrast echocardiography: a 25-year retrospective. Circulation. 2008;118(3):291–308. doi:10.1161/circulationaha.107.747303.

    Article  PubMed  Google Scholar 

  8. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998;97(5):473–83.

    Article  CAS  PubMed  Google Scholar 

  9. Le DE, Bin JP, Coggins MP, Wei K, Lindner JR, Kaul S. Relation between myocardial oxygen consumption and myocardial blood volume: a study using myocardial contrast echocardiography. J Am Soc Echocardiogr. 2002;15(9):857–63.

    Article  PubMed  Google Scholar 

  10. Ito H, Tomooka T, Sakai N, Yu H, Higashino Y, Fujii K, Masuyama T, Kitabatake A, Minamino T. Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation. 1992;85(5):1699–705.

    Article  CAS  PubMed  Google Scholar 

  11. Ragosta M, Camarano G, Kaul S, Powers ER, Sarembock IJ, Gimple LW. Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography. Circulation. 1994;89(6):2562–9.

    Article  CAS  PubMed  Google Scholar 

  12. Ito H, Maruyama A, Iwakura K, Takiuchi S, Masuyama T, Hori M, Higashino Y, Fujii K, Minamino T. Clinical implications of the ‘no reflow’ phenomenon. A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation. 1996;93(2):223–8.

    Article  CAS  PubMed  Google Scholar 

  13. Shimoni S, Frangogiannis NG, Aggeli CJ, Shan K, Verani MS, Quinones MA, Espada R, Letsou GV, Lawrie GM, Winters WL, Reardon MJ, Zoghbi WA. Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy. Circulation. 2003;107(4):538–44.

    Article  PubMed  Google Scholar 

  14. Hoit BD. Strain and strain rate echocardiography and coronary artery disease. Circ Cardiovasc Imaging. 2011;4(2):179–90. doi:10.1161/circimaging.110.959817.

    Article  PubMed  Google Scholar 

  15. Gorcsan 3rd J, Tanaka H. Echocardiographic assessment of myocardial strain. J Am Coll Cardiol. 2011;58(14):1401–13. doi:10.1016/j.jacc.2011.06.038.

    Article  PubMed  Google Scholar 

  16. Hoffmann R, Altiok E, Nowak B, Heussen N, Kuhl H, Kaiser HJ, Bull U, Hanrath P. Strain rate measurement by doppler echocardiography allows improved assessment of myocardial viability in patients with depressed left ventricular function. J Am Coll Cardiol. 2002;39(3):443–9.

    Article  PubMed  Google Scholar 

  17. Hanekom L, Jenkins C, Jeffries L, Case C, Mundy J, Hawley C, Marwick TH. Incremental value of strain rate analysis as an adjunct to wall-motion scoring for assessment of myocardial viability by dobutamine echocardiography: a follow-up study after revascularization. Circulation. 2005;112(25):3892–900. doi:10.1161/circulationaha.104.489310.

    Article  PubMed  Google Scholar 

  18. Ran H, Zhang PY, Fang LL, Ma XW, Wu WF, Feng WF. Clinic value of two-dimensional speckle tracking combined with adenosine stress echocardiography for assessment of myocardial viability. Echocardiography. 2012;29(6):688–94. doi:10.1111/j.1540-8175.2012.01690.x.

    Article  PubMed  Google Scholar 

  19. Rasmussen S, Corya BC, Feigenbaum H, Knoebel SB. Detection of myocardial scar tissue by M-mode echocardiography. Circulation. 1978;57(2):230–7.

    Article  CAS  PubMed  Google Scholar 

  20. Lieberman AN, Weiss JL, Jugdutt BI, Becker LC, Bulkley BH, Garrison JG, Hutchins GM, Kallman CA, Weisfeldt ML. Two-dimensional echocardiography and infarct size: relationship of regional wall motion and thickening to the extent of myocardial infarction in the dog. Circulation. 1981;63(4):739–46.

    Article  CAS  PubMed  Google Scholar 

  21. Cwajg JM, Cwajg E, Nagueh SF, He ZX, Qureshi U, Olmos LI, Quinones MA, Verani MS, Winters WL, Zoghbi WA. End-diastolic wall thickness as a predictor of recovery of function in myocardial hibernation: relation to rest-redistribution T1-201 tomography and dobutamine stress echocardiography. J Am Coll Cardiol. 2000;35(5):1152–61.

    Article  CAS  PubMed  Google Scholar 

  22. Zaglavara T, Pillay T, Karvounis H, Haaverstad R, Parharidis G, Louridas G, Kenny A. Detection of myocardial viability by dobutamine stress echocardiography: incremental value of diastolic wall thickness measurement. Heart. 2005;91(5):613–7. doi:10.1136/hrt.2003.028316.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Romero J, Xue X, Gonzalez W, Garcia MJ. CMR imaging assessing viability in patients with chronic ventricular dysfunction due to coronary artery disease: a meta-analysis of prospective trials. JACC Cardiovasc Imaging. 2012;5(5):494–508. doi:10.1016/j.jcmg.2012.02.009.

    Article  PubMed  Google Scholar 

  24. Shah DJ, Kim HW, James O, Parker M, Wu E, Bonow RO, Judd RM, Kim RJ. Prevalence of regional myocardial thinning and relationship with myocardial scarring in patients with coronary artery disease. JAMA. 2013;309(9):909–18. doi:10.1001/jama.2013.1381.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Allman KC. Noninvasive assessment myocardial viability: current status and future directions. J Nucl Cardiol. 2013;20(4):618–37. doi:10.1007/s12350-013-9737-8. quiz 638-9.

    Article  PubMed  Google Scholar 

  26. Mendoza DD, Weigold WG. Evaluation of myocardial viability by multidetector CT. J Cardiovasc Comput Tomogr. 2009;3(1 Suppl):S2–12. doi:10.1016/j.jcct.2008.10.015.

    Article  PubMed  Google Scholar 

  27. Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation. 2002;105(2):224–9.

    Article  PubMed  Google Scholar 

  28. Kim RJ, Shah DJ, Judd RM. How we perform delayed enhancement imaging. J Cardiovasc Magn Reson. 2003;5(3):505–14.

    Article  PubMed  Google Scholar 

  29. Kim RJ, Albert TS, Wible JH, Elliott MD, Allen JC, Lee JC, Parker M, Napoli A, Judd RM, Gadoversetamide Myocardial Infarction Imaging Investigators. Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial. Circulation. 2008;117(5):629–37. doi:10.1161/CIRCULATIONAHA.107.723262.

    Article  PubMed  Google Scholar 

  30. Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Klocke FJ, Bonow RO, Judd RM. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343(20):1445–53. doi:10.1056/NEJM200011163432003.

    Article  CAS  PubMed  Google Scholar 

  31. Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104(10):1101–7.

    Article  CAS  PubMed  Google Scholar 

  32. Kim RJ, Shah DJ. Fundamental concepts in myocardial viability assessment revisited: when knowing how much is “alive” is not enough. Heart. 2004;90(2):137–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol. 2002;39(7):1151–8.

    Article  PubMed  Google Scholar 

  34. Velazquez EJ, Lee KL, Deja MA, Jain A, Sopko G, Marchenko A, Ali IS, Pohost G, Gradinac S, Abraham WT, Yii M, Prabhakaran D, Szwed H, Ferrazzi P, Petrie MC, O’Connor CM, Panchavinnin P, She L, Bonow RO, Rankin GR, Jones RH, Rouleau JL, STICH Investigators. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med. 2011;364(17):1607–16. doi:10.1056/NEJMoa1100356.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Bonow RO, Maurer G, Lee KL, Holly TA, Binkley PF, Desvigne-Nickens P, Drozdz J, Farsky PS, Feldman AM, Doenst T, Michler RE, Berman DS, Nicolau JC, Pellikka PA, Wrobel K, Alotti N, Asch FM, Favaloro LE, She L, Velazquez EJ, Jones RH, Panza JA, STICH Trial Investigators. Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med. 2011;364(17):1617–25. doi:10.1056/NEJMoa1100358.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Chetan Shenoy MBBS .

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Nijjar, P.S., Tamene, A.M., Shenoy, C. (2017). Myocardial Viability and Imaging in the Failing Heart. In: Garry, D., Wilson, R., Vlodaver, Z. (eds) Congestive Heart Failure and Cardiac Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-44577-9_14

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  • DOI: https://doi.org/10.1007/978-3-319-44577-9_14

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