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Dilated Cardiomyopathy

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Clinical Cardiogenetics

Abstract

Dilated cardiomyopathy (DCM) is characterized by impaired left ventricular (LV) systolic function and left ventricular dilation. Remarkable progress has been made in understanding the genetic basis of idiopathic dilated cardiomyopathy (iDCM). Rare variants in >30 genes, some also involved in other cardiomyopathies, muscular dystrophy, or syndromic disease, perturb a diverse set of important myocardial proteins to produce a final DCM phenotype. Recommendations on genetic screening and cardiac screening are provided in this chapter.

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Authors and Affiliations

  1. Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands

    J. A. Jansweijer

  2. Department of Human Genetics, Ohio State University College of Medicine, Tilburg, Columbus, Ohio, USA

    R. Hershberger

  3. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    K. Y. Van Spaendonck

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  1. J. A. Jansweijer
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  3. K. Y. Van Spaendonck
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  1. Department of Cardiology, St. Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands

    Hubert F. Baars

  2. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

    Pieter A. F. M. Doevendans

  3. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands

    Arjan C. Houweling

  4. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    J. Peter van Tintelen

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Jansweijer, J.A., Hershberger, R., Van Spaendonck, K.Y. (2016). Dilated Cardiomyopathy. In: Baars, H., Doevendans, P., Houweling, A., van Tintelen, J. (eds) Clinical Cardiogenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-44203-7_5

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