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Short QT Syndrome

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Clinical Cardiogenetics

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Abstract

In 2000, Gussak et al. first described an idiopathic short QT interval associated with atrial fibrillation (AF) in one family and a sudden death in an unrelated individual (Gussak et al. Cardiology 94:99–102, 2000). Three years later, in 2003, Gaita et al. reported the association of a short QT interval and sudden cardiac death in two unrelated European families (Gaita et al. Circulation 108:965–70, 2003). Within the following years, a variety of mutations in different genes most likely causative for the short QT interval were identified. The initially reported mutations either caused a gain of function of cardiac potassium channels IKr, IKs, and IK1, or a loss of function in the cardiac L-type calcium channel (ICa) (Bellocq et al. Circulation 109:2394–7, 2004; Priori et al. Circ Res 96:800–7, 2005; Antzelevitch et al. Circulation 115:442–9, 2007; Hong et al. Cardiovasc Res 68:433–40, 2005; Brugada et al. Circulation 109:30–5, 2004; El Harchi et al. PLoS One 7:e52451, 2012; Moreno et al. Cardiovasc Res 107:613–23, 2015; Giustetto et al. Eur Heart J 27:2440–7; 2006).

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Authors and Affiliations

  1. Department of Medicine – Cardiology, Klinikum Ludwigsburg, Posilipostraße 4, 71640, Ludwigsburg, Germany

    Christian Wolpert MD & Norman Rüb MD

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  1. Christian Wolpert MD
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  2. Norman Rüb MD
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Correspondence to Christian Wolpert MD .

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Editors and Affiliations

  1. Department of Cardiology, St. Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands

    Hubert F. Baars

  2. Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

    Pieter A. F. M. Doevendans

  3. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands

    Arjan C. Houweling

  4. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    J. Peter van Tintelen

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Wolpert, C., Rüb, N. (2016). Short QT Syndrome. In: Baars, H., Doevendans, P., Houweling, A., van Tintelen, J. (eds) Clinical Cardiogenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-44203-7_13

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  • DOI: https://doi.org/10.1007/978-3-319-44203-7_13

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