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Hot Flashes: Phenomenology and Measurement

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Biological Measures of Human Experience across the Lifespan

Abstract

Hot flashes are a highly prevalent symptom experienced by women transitioning through menopause, as well as by men and women undergoing certain cancer-related treatments. Though many individuals do not find these symptoms troublesome, others suffer from severe and frequent symptoms and related decrements in sleep, psychological well-being, sexual health and overall quality of life. In order to develop a better understanding of the etiology and treatment options for hot flashes, accurate measurement is vital. This chapter provides an overview of hot flash measurement both physiologic, and via self-report measures. It critically evaluates the four categories of hot flash measurement tools: symptom scales based on retrospective reporting over weeks and months, daily diaries completed by end of day, daily diaries completed at the time of the hot flash, and physiologic measures of hot flashes. Further, the impact of psychological/emotional influences, ethnic differences, and body mass on hot flash reporting is discussed. Finally, this chapter provides recommendations for the future development and refinement of hot flash reporting tools and suggestions for best-practice hot flash measurement methodology.

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References

  • Anderson, G. S. (1999). Human morphology and temperature regulation. International Journal of Biometeorology, 43(3), 99–109.

    Article  Google Scholar 

  • Armstrong, L. E., & Pandolf, K. B. (1988). Physical training, cardiorespiratory physical fitness and exercise-heat tolerance. In K. B. Pandolf, M. N. Sawka, & R. R. Gonzalez (Eds.), Human performance physiology and environmental medicine at terrestrial extremes (pp. 199–226). Indianapolis: Benchmark Press.

    Google Scholar 

  • Avis, N. E., Colvin, A., Bromberger, J. T., Hess, R., Matthews, K. A., Ory, M., et al. (2009). Change in health-related quality of life over the menopausal transition in a multiethnic cohort of middle-aged women: Study of Women’s Health Across the Nation (SWAN). Menopause, 16(5), 860–869.

    Article  Google Scholar 

  • Avis, N. E., Crawford, S. L., Bromberger, J., Everson-Rose, S. A., Greendale, G. A., & Gold, E. B. (2013). Duration of vasomotor symptoms during the menopausal transition. Journal of Women’s Health, 22(Published Abstract), 3.

    Google Scholar 

  • Avis, N. E., Kaufert, P. A., Lock, M., McKinlay, S. M., & Vass, K. (1993). The evolution of menopausal symptoms. Baillieres Clinical Endocrinology and Metabolism, 7(1), 17–32.

    Article  Google Scholar 

  • Bechlioulis, A., Kalantaridou, S. N., Naka, K. K., Chatzikyriakidou, A., Calis, K. A., Makrigiannakis, A., et al. (2010). Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes. The Journal of Clinical Endocrinology & Metabolism, 95(3), 1199–1206.

    Article  Google Scholar 

  • Berendsen, H. H. (2000). The role of serotonin in hot flushes. Maturitas, 36(3), 155–164.

    Article  Google Scholar 

  • Besch, C. L. (1995). Compliance in clinical trials. AIDS, 9(1), 1–10.

    Article  Google Scholar 

  • Bradburn, N. M., Rips, L. J., & Shevell, S. K. (1987). Answering autobiographical questions: the impact of memory and inference on surveys. Science, 236(4798), 157–161.

    Article  Google Scholar 

  • Bromberger, J. T., Matthews, K. A., Schott, L. L., Brockwell, S., Avis, N. E., Kravitz, H. M., et al. (2007). Depressive symptoms during the menopausal transition: The Study of Women’s Health Across the Nation (SWAN). Journal of Affective Disorders, 103(1–3), 267–272. doi:10.1016/j.jad.2007.01.034

    Article  Google Scholar 

  • Brown, D. E., Sievert, L. L., Morrison, L. A., Reza, A. M., & Mills, P. S. (2009). Do Japanese American women really have fewer hot flashes than European Americans? The Hilo women’s health study. Menopause, 16(5), 870.

    Article  Google Scholar 

  • Buskirk, E. R., Lundegre, H., & Magnusso, L. (1965). Heat acclimatization patterns in obese and lean individuals. Annals of the New York Academy of Science, 131(A1), 637–653. doi:10.1111/j.1749-6632.1965.tb34827.x

    Article  Google Scholar 

  • Buysse, D. J., Reynolds, C. F., 3rd, Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193–213.

    Article  Google Scholar 

  • Byrne, B. M., & Campbell, T. L. (1999). Cross-cultural comparisons and the presumption of equivalent measurement and theoretical structure—A look beneath the surface. Journal of Cross-Cultural Psychology, 30(5), 555–574. doi:10.1177/0022022199030005001

    Article  Google Scholar 

  • Campbell, I. G., Bromberger, J. T., Buysse, D. J., Hall, M. H., Hardin, K. A., Kravitz, H. M., et al. (2011). Evaluation of the association of menopausal status with delta and beta EEG activity during sleep. Sleep, 34(11), 1561–1568. doi:10.5665/sleep.1398

    Google Scholar 

  • Carpenter, J. S. (2001). The hot flash related daily interference scale: A tool for assessing the impact of hot flashes on quality of life following breast cancer. Journal of Pain and Symptom Management, 22(6), 979–989.

    Article  Google Scholar 

  • Carpenter, J. S., Andrykowski, M. A., Cordova, M., Cunningham, L., Studts, J., McGrath, P., et al. (1998). Hot flashes in postmenopausal women treated for breast carcinoma: Prevalence, severity, correlates, management, and relation to quality of life. Cancer, 82(9), 1682–1691.

    Article  Google Scholar 

  • Carpenter, J. S., Andrykowski, M. A., Freedman, R. R., & Munn, R. (1999). Feasibility and psychometrics of an ambulatory hot flash monitoring device. Menopause, 6(3), 209–215.

    Article  Google Scholar 

  • Carpenter, J. S., Azzouz, F., Monahan, P. O., Storniolo, A. M., & Ridner, S. H. (2005). Is sternal skin conductance monitoring a valid measure of hot flash intensity or distress? Menopause, 12(5), 512–519. doi:10.1097/01.gme.0000170957.31542.1c

    Article  Google Scholar 

  • Carpenter, J. S., Newton, K. M., Sternfeld, B., Joffe, H., Reed, S. D., Ensrud, K. E., et al. (2012). Laboratory and ambulatory evaluation of vasomotor symptom monitors from the Menopause Strategies Finding Lasting Answers for Symptoms and Health network. Menopause, 19(6), 664–671. doi:10.1097/gme.0b013e31823dbbe3

    Article  Google Scholar 

  • Carpenter, J. S., & Rand, K. L. (2008). Modeling the hot flash experience in breast cancer survivors. Menopause, 15(3), 469–475. doi:10.1097/gme.0b013e3181591db7

    Article  Google Scholar 

  • Carpenter, J. S., Storniolo, A. M., Johns, S., Monahan, P. O., Azzouz, F., Elam, J. L., et al. (2007). Randomized, double-blind, placebo-controlled crossover trials of venlafaxine for hot flashes after breast cancer. Oncologist, 12(1), 124–135. doi:10.1634/theoncologist.12-1-124

    Article  Google Scholar 

  • Chedraui, P., Perez-Lopez, F. R., Sanchez, H., Aguirre, W., Martinez, N., Miranda, O., et al. (2012). Assessment of sexual function of mid-aged Ecuadorian women with the 6-item female sexual function index. Maturitas, 71(4), 407–412. doi:10.1016/j.maturitas.2012.01.013

    Article  Google Scholar 

  • Collett, M. (1949). Basal metabolism at the menopause. Journal of Applied Physiology, 1(9), 629–636.

    Google Scholar 

  • Crawford, S. L. (2007). The roles of biologic and nonbiologic factors in cultural differences in vasomotor symptoms measured by surveys. Menopause, 14(4), 725–733. doi:10.1097/GME.0b013e31802efbb2

    Google Scholar 

  • de Bakker, I. P., & Everaerd, W. (1996). Measurement of menopausal hot flushes: Validation and cross-validation. Maturitas, 25(2), 87–98.

    Article  Google Scholar 

  • de Zambotti, M., Colrain, I. M., Sassoon, S. A., Nicholas, C. L., Trinder, J., & Baker, F. C. (2013). Vagal withdrawal during hot flashes occurring in undisturbed sleep. Menopause, 20(11), 1147–1153. doi:10.1097/GME.0b013e31828aa344

    Article  Google Scholar 

  • Eich, E., Reeves, J. L., Jaeger, B., & Graffradford, S. B. (1985). Memory for pain—Relation between past and present pain intensity. Pain, 23(4), 375–379. doi:10.1016/0304-3959(85)90007-7

    Article  Google Scholar 

  • Erlik, Y., Tataryn, I. V., Meldrum, D. R., Lomax, P., Bajorek, J. G., & Judd, H. L. (1981). Association of waking episodes with menopausal hot flushes. Journal of the American Medical Association, 245(17), 1741–1744.

    Article  Google Scholar 

  • Flegal, K. M., Carroll, M. D., Ogden, C. L., & Curtin, L. R. (2010). Prevalence and trends in obesity among US adults, 1999–2008. Journal of the American Medical Association, 303(3), 235–241. doi:10.1001/jama.2009.2014

    Article  Google Scholar 

  • Freedman, R. R. (1989). Laboratory and ambulatory monitoring of menopausal hot flashes. Psychophysiology, 26(5), 573–579.

    Article  Google Scholar 

  • Freedman, R. R. (1998). Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes. Fertility and Sterility, 70(2), 332–337.

    Article  Google Scholar 

  • Freedman, R. R. (2000). Chapter 14: Menopausal hot flashes. In R. A. Lobo, J. Kelsey, & R. Marcus (Eds.), Menopause: Biology and pathobiology (pp. 215–227). San Diego: Academic Press.

    Chapter  Google Scholar 

  • Freedman, R. R. (2001). Physiology of hot flashes. American Journal of Human Biology, 13(4), 453–464. doi:10.1002/ajhb.1077

    Article  Google Scholar 

  • Freedman, R. R. (2005). Pathophysiology and treatment of menopausal hot flashes. Seminars in Reproductive Medicine, 23, 117–125.

    Article  Google Scholar 

  • Freedman, R. R., Benton, M. D., Genik, R. J., 2nd, & Graydon, F. X. (2006). Cortical activation during menopausal hot flashes. Fertility and Sterility, 85(3), 674–678. doi:10.1016/j.fertnstert.2005.08.026

    Article  Google Scholar 

  • Freedman, R. R., & Roehrs, T. A. (2004). Lack of sleep disturbance from menopausal hot flashes. Fertility and Sterility, 82(1), 138–144. doi:10.1016/j.fertnstert.2003.12.029

    Article  Google Scholar 

  • Freedman, R. R., & Roehrs, T. A. (2006). Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance. Menopause, 13(4), 576–583. doi:10.1097/01.gme.0000227398.53192.bc

    Article  Google Scholar 

  • Freedman, R. R., & Roehrs, T. A. (2007). Sleep disturbance in menopause. Menopause, 14(5), 826–829. doi:10.1097/GME.0b013e3180321a22

    Article  Google Scholar 

  • Freedman, R. S., & Wasson, S. (2007). Miniature hygrometric hot flash recorder. Fertility and Sterility, 88(2), 494–496.

    Article  Google Scholar 

  • Freeman, E. W., Guthrie, K. A., Caan, B., Sternfeld, B., Cohen, L. S., Joffe, H., et al. (2011a). Efficacy of escitalopram for hot flashes in healthy menopausal women: A randomized controlled trial. Journal of the American Medical Association, 305(3), 267–274. doi:10.1001/jama.2010.2016

    Article  Google Scholar 

  • Freeman, E. W., Sammel, M. D., Hui, L., Ziyue, L., & Gracia, C. R. (2011b). Duration of menopausal hot flushes and associated risk factors. Obstetrics and Gynecology, 117(5), 1095–1104. doi:10.1097/AOG.0b013e318214f0de

    Article  Google Scholar 

  • Freeman, E. W., Sammel, M. D., & Lin, H. (2009). Temporal associations of hot flashes and depression in the transition to menopause. Menopause, 16(4), 728–734. doi:10.1097/gme.0b013e3181967e16

    Article  Google Scholar 

  • Freeman, E. W., Sammel, M. D., Lin, H., Gracia, C. R., Kapoor, S., & Ferdousi, T. (2005). The role of anxiety and hormonal changes in menopausal hot flashes. Menopause, 12(3), 258–266.

    Article  Google Scholar 

  • Freeman, E. W., & Sherif, K. (2007). Prevalence of hot flushes and night sweats around the world: A systematic review. Climacteric, 10(3), 197–214. doi:10.1080/13697130601181486

    Article  Google Scholar 

  • Frödin, T., Ålund, G., & Varenhorst, E. (1985). Measurement of skin blood-flow and water evaporation as a means of objectively assessing hot flushes after orchidectomy in patients with prostatic cancer. The Prostate, 7(2), 203–208.

    Article  Google Scholar 

  • Fu, P., Matthews, K. A., & Thurston, R. C. (2014). How well do different measurement modalities estimate the number of vasomotor symptoms? Findings from the Study of Women’s Health Across the Nation FLASHES Study. Menopause, 21(2), 124–130. doi:10.1097/GME.0b013e318295a3b9

    Article  Google Scholar 

  • Gibson, C. J., Matthews, K., & Thurston, R. (2014). Daily physical activity and hot flashes in the Study of Women’s Health Across the Nation (SWAN) Flashes Study. Fertility and Sterility, 101(4), 1110–1116. doi:10.1016/j.fertnstert.2013.12.029

    Article  Google Scholar 

  • Gibson, C. J., Thurston, R. C., Bromberger, J. T., Kamarck, T., & Matthews, K. A. (2011). Negative affect and vasomotor symptoms in the Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study. Menopause, 18(12), 1270.

    Article  Google Scholar 

  • Ginsburg, J., Swinhoe, J., & O’Reilly, B. (1981). Cardiovascular responses during the menopausal hot flush. British Journal of Obsterics and Gynaecology, 88(9), 925–930.

    Article  Google Scholar 

  • Gold, E. B., Colvin, A., Avis, N., Bromberger, J., Greendale, G. A., Powell, L., et al. (2006). Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: Study of women’s health across the nation. American Journal of Public Health, 96(7), 1226–1235. doi:10.2105/AJPH.2005.066936

    Article  Google Scholar 

  • Gold, E. B., Sternfeld, B., Kelsey, J. L., Brown, C., Mouton, C., Reame, N., et al. (2000). Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. American Journal of Epidemiology, 152(5), 463–473.

    Article  Google Scholar 

  • Gonzalez-Calvo, J., Gonzalez, V. M., & Lorig, K. (1997). Cultural diversity issues in the development of valid and reliable measures of health status. Arthritis Care Research, 10(6), 448–456. doi:10.1002/art.1790100613

    Article  Google Scholar 

  • Grady, D., Macer, J., Kristof, M., Shen, H., Tagliaferri, M., & Creasman, J. (2009). Is a shorter hot flash diary just as good as a 7-day diary? Menopause, 16(5), 932–936. doi:10.1097/gme.0b013e3181a4f558

    Article  Google Scholar 

  • Green, R., Polotsky, A. J., Wildman, R. P., McGinn, A. P., Lin, J., Derby, C., et al. (2010). Menopausal symptoms within a Hispanic cohort: SWAN, the Study of Women’s Health Across the Nation. Climacteric, 13(4), 376–384. doi:10.3109/13697130903528272

    Article  Google Scholar 

  • Greene, J. G. (1976). A factor analytic study of climacteric symptoms. Journal of Psychosomatic Research, 20(5), 425–430.

    Article  Google Scholar 

  • Hanisch, L. J., Hantsoo, L., Freeman, E. W., Sullivan, G. M., & Coyne, J. C. (2008). Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition. Psychological Bulletin, 134(2), 247–269. doi:10.1037/0033-2909.134.2.247

    Article  Google Scholar 

  • Hanisch, L. J., Palmer, S. C., Donahue, A., & Coyne, J. C. (2007). Validation of sternal skin conductance for detection of hot flashes in prostate cancer survivors. Psychophysiology, 44(2), 189–193. doi:10.1111/j.1469-8986.2007.00492.x

    Article  Google Scholar 

  • Hauser, G. A., Huber, I. C., Keller, P. J., Lauritzen, C., & Schneider, H. P. (1994). Evaluation of climacteric symptoms (Menopause Rating Scale). Zentralblatt für Gynäkologie, 116(1), 16–23.

    Google Scholar 

  • Havenith, G., Luttikholt, V. G., & Vrijkotte, T. G. (1995). The relative influence of body characteristics on humid heat stress response. European Journal of Applied Physiology and Occupational Physiology, 70(3), 270–279.

    Article  Google Scholar 

  • Havenith, G., & van Middendorp, H. (1990). The relative influence of physical fitness, acclimatization state, anthropometric measures and gender on individual reactions to heat stress. European Journal of Applied Physiology and Occupational Physiology, 61(5–6), 419–427. doi:10.1007/BF00236062

    Article  Google Scholar 

  • Hilditch, J. R., Lewis, J., Peter, A., van Maris, B., Ross, A., Franssen, E., et al. (1996). A menopause-specific quality of life questionnaire: Development and psychometric properties. Maturitas, 24(3), 161–175.

    Article  Google Scholar 

  • Hunter, M. S. (1992). The Women’s Health Questionnaire: A measure of mid-aged women’s perceptions of their emotional and physical health. Psychology and Health, 7(1), 45–54.

    Article  Google Scholar 

  • Hunter, M. S., Gentry-Maharaj, A., Ryan, A., Burnell, M., Lanceley, A., Fraser, L., et al. (2012). Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: Impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10,418 British women aged 54–65. BJOG, 119(1), 40–50. doi:10.1111/j.1471-0528.2011.03166.x

    Article  Google Scholar 

  • Hunter, M. S., & Liao, K. L. (1995). A psychological analysis of menopausal hot flushes. British Journal of Clinical Psychology, 34(Pt 4), 589–599.

    Article  Google Scholar 

  • Joffe, H., White, D. P., Crawford, S. L., McCurnin, K. E., Economou, N., Connors, S., et al. (2013). Adverse effects of induced hot flashes on objectively recorded and subjectively reported sleep: Results of a gonadotropin-releasing hormone agonist experimental protocol. Menopause, 20(9), 905–914. doi:10.1097/GME.0b013e31828292d1

    Article  Google Scholar 

  • Kravitz, H. M., Zhao, X., Bromberger, J. T., Gold, E. B., Hall, M. H., Matthews, K. A., et al. (2008). Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep, 31(7), 979–990.

    Google Scholar 

  • Kronenberg, F. (1990). Hot flashes: Epidemiology and physiology. Annals of the New York Academy of Science, 592, 52–86. (discussion 123–133).

    Article  Google Scholar 

  • Kronenberg, F. (1994). Hot flashes: Phenomenology, quality of life, and search for treatment options. Experimental Gerontology, 29(3–4), 319–336.

    Article  Google Scholar 

  • Kronenberg, F. (2010). Menopausal hot flashes: A review of physiology and biosociocultural perspective on methods of assessment. The Journal of Nutrition, 140(7), 1380S–1385S. doi:10.3945/jn.109.120840

    Article  Google Scholar 

  • Kronenberg, F., Cote, L. J., Linkie, D. M., Dyrenfurth, I., & Downey, J. A. (1984). Menopausal hot flashes: Thermoregulatory, cardiovascular, and circulating catecholamine and LH changes. Maturitas, 6(1), 31–43.

    Article  Google Scholar 

  • Kupperman, H. S., Blatt, M. H., Wisebader, H., & Filler, W. (1953). Comparative clinical evaluation of estrogenic preperations by the menopausal and amenorrheal indices. The Journal of Clinical Endocrinology & Metabolism, 13(6), 688–703.

    Article  Google Scholar 

  • Lambrinoudaki, I., Augoulea, A., Armeni, E., Rizos, D., Alexandrou, A., Creatsa, M., et al. (2012). Menopausal symptoms are associated with subclinical atherosclerosis in healthy recently postmenopausal women. Climacteric, 15(4), 350–357. doi:10.3109/13697137.2011.618564

    Article  Google Scholar 

  • Leidy, L. E. (1997). Menopausal symptoms and everyday complaints. Menopause, 4(3), 154–160.

    Article  Google Scholar 

  • Maki, P. M., Drogos, L. L., Rubin, L. H., Banuvar, S., Shulman, L. P., & Geller, S. E. (2008). Objective hot flashes are negatively related to verbal memory performance in midlife women. Menopause, 15(5), 848.

    Article  Google Scholar 

  • Mann, E., & Hunter, M. S. (2011). Concordance between self-reported and sternal skin conductance measures of hot flushes in symptomatic perimenopausal and postmenopausal women: A systematic review. Menopause, 18(6), 709–722. doi:10.1097/gme.0b013e318204a1fb

    Article  Google Scholar 

  • McCall, C., & McCall, W. V. (2012). Comparison of actigraphy with polysomnography and sleep logs in depressed insomniacs. Journal of Sleep Research, 21(1), 122–127. doi:10.1111/j.1365-2869.2011.00917.x

    Article  Google Scholar 

  • Melby, M. K. (2005). Vasomotor symptom prevalence and language of menopause in Japan. Menopause, 12(3), 250–257.

    Article  Google Scholar 

  • Miller, H. G., & Li, R. M. (2004). Measuring hot flashes: Summary of a National Institutes of Health Workshop. In Mayo Clinic proceedings (Vol. 79, No. 6, p. 777).

    Google Scholar 

  • Molnar, G. (1975). Body temperatures during menopausal hot flashes. Journal of Applied Physiology, 38(3), 499–503.

    Google Scholar 

  • Nelson, H. D. (2004). Commonly used types of postmenopausal estrogen for treatment of hot flashes—Scientific review. JAMA: Journal of the American Medical Association, 291(13), 1610–1620. doi:10.1001/jama.291.13.1610

    Article  Google Scholar 

  • Oldenhave, A., Jaszmann, L. J., Haspels, A. A., & Everaerd, W. T. (1993). Impact of climacteric on well-being. A survey based on 5213 women 39 to 60 years old. American Journal of Obstetrics and Gynecology, 168(3 Pt 1), 772–780.

    Article  Google Scholar 

  • Otte, J. L., Flockhart, D., Storniolo, A. M., Schneider, B., Azzouz, F., Lemler, S., et al. (2009). Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy. Menopause, 16(4), 653.

    Article  Google Scholar 

  • Perz, J. M. (1997). Development of the menopause symptom list: A factor analytic study of menopause associated symptoms. Women and Health, 25(1), 53–69. doi:10.1300/J013v25n01_04

    Article  Google Scholar 

  • Quan, N., Xin, L., & Blatteis, C. M. (1991). Microdialysis of norepinephrine into preoptic area of guinea pigs: Characteristics of hypothermic effect. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 261(2), R378–R385.

    Google Scholar 

  • Regestein, Q. R. (2006). Hot flashes and sleep. Menopause, 13(4), 549–552. doi:10.1097/01.gme.0000227395.30321.ff

    Article  Google Scholar 

  • Reynolds, S. (1941). Dermovascular action of estrogen, the ovarian follicular hormone. Journal of Investigative Dermatology, 4(1), 7–22. doi:10.1038/jid.1941.3

    Article  Google Scholar 

  • Rickles, W., & Day, J. (1968). Electrodermal activity in non-palmer skin sites. Psychophysiology, 4(4), 421–435.

    Article  Google Scholar 

  • Savard, M. H., Savard, J., & Ivers, H. (2014). Validation of a sternal skin conductance criterion for measuring hot flashes in breast cancer patients. Menopause, 21(2), 165–169. doi:10.1097/GME.0b013e3182947af3

    Article  Google Scholar 

  • Savard, M. H., Savard, J., Quesnel, C., & Ivers, H. (2009). The influence of breast cancer treatment on the occurrence of hot flashes. Journal of Pain and Symptom Management, 37(4), 687–697. doi:10.1016/j.jpainsymman.2008.04.010

    Article  Google Scholar 

  • Shiffman, S., Hufford, M. R., & Paty, J. (2001). Subject experience diaries in clinical research, Part 1: The patient experience movement. Applied Clinical Trials, 10(2), 46–57.

    Google Scholar 

  • Sievert, L. L. (2007). Variation in sweating patterns: Implications for studies of hot flashes through skin conductance. Menopause, 14(4), 742–751. doi:10.1097/gme.0b013e3180577841

    Article  Google Scholar 

  • Sievert, L.L. (2012). Choosing the gold standard: Subjective report vs. physiological measure (Vol. 5, No. 3, pp. e1–e18). Insights, Institute of Advanced Study, Durham University, UK.

    Google Scholar 

  • Sievert, L. L. (2014). Menopause across cultures: Clinical considerations. Menopause, 21(4), 421–423. doi:10.1097/GME.0000000000000099

    Google Scholar 

  • Sievert, L. L., Begum, K., Sharmeen, T., Chowdhury, O., Muttukrishna, S., & Bentley, G. (2008). Patterns of occurrence and concordance between subjective and objective hot flashes among Muslim and Hindu women in Sylhet, Bangladesh. American Journal of Human Biology, 20(5), 598–604. doi:10.1002/Ajhb.20785

    Article  Google Scholar 

  • Sievert, L. L., & Espinosa-Hernandez, G. (2003). Attitudes toward menopause in relation to symptom experience in Puebla, Mexico. Women and Health, 38(2), 93–106. doi:10.1300/J013v38n02_07

    Article  Google Scholar 

  • Sievert, L. L., Freedman, R. R., Garcia, J. Z., Foster, J. W., del Carmen Romano Soriano, M., Longcope, C., et al. (2002). Measurement of hot flashes by sternal skin conductance and subjective hot flash report in Puebla, Mexico. Menopause, 9(5), 367–376.

    Article  Google Scholar 

  • Sievert, L. L., Vidovic, M., Horak, H., & Abel, M. (2004). Age and symptom experience at menopause in the Selska Valley, Slovenia. Menopause, 11(2), 223–227. doi:10.1097/01.Gme.0000087982.28957.14

    Article  Google Scholar 

  • Sloan, J. A., Loprinzi, C. L., Novotny, P. J., Barton, D. L., Lavasseur, B. I., & Windschitl, H. (2001). Methodologic lessons learned from hot flash studies. Journal of Clinical Oncology, 19(23), 4280–4290.

    Google Scholar 

  • Spetz, A. C., Hammar, M., Lindberg, B., Spangberg, A., & Varenhorst, E. (2001). Prospective evaluation of hot flashes during treatment with parenteral estrogen or complete androgen ablation for metastatic carcinoma of the prostate. Journal of Urology, 166(2), 517–520.

    Article  Google Scholar 

  • Stefanopoulou, E., & Hunter, M. S. (2013). Does pattern recognition software using the Bahr monitor improve the sensitivity, specificity, and concordance of ambulatory skin conductance monitoring of hot flushes? Menopause, 20(11), 1133–1138. doi:10.1097/GME.0b013e3182894f6d

    Article  Google Scholar 

  • Stein, K. D., Jacobsen, P. B., Hann, D. M., Greenberg, H., & Lyman, G. (2000). Impact of hot flashes on quality of life among postmenopausal women being treated for breast cancer. Journal of Pain and Symptom Management, 19(6), 436–445.

    Article  Google Scholar 

  • Stone, A. A., & Shiffman, S. (2002). Capturing momentary, self-report data: A proposal for reporting guidelines. Annals of Behavioral Medicine, 24(3), 236–243.

    Article  Google Scholar 

  • Stone, A. A., Shiffman, S., Schwartz, J. E., Broderick, J. E., & Hufford, M. R. (2003). Patient compliance with paper and electronic diaries. Controlled Clinical Trials, 24(2), 182–199. doi:10.1016/S0197-2456(02)00320-3

    Article  Google Scholar 

  • Tataryn, I., Lomax, P., Bajorek, J., Chesarek, W., Meldrum, D., & Judd, H. (1980). Postmenopausal hot flushes: A disorder of thermoregulation. Maturitas, 2(2), 101–107.

    Article  Google Scholar 

  • Tataryn, I., Lomax, P., Meldrum, D., Bajorek, J., Chesarek, W., & Judd, H. (1981). Objective techniques for the assessment of postmenopausal hot flashes. Obstetrics and Gynecology, 57(3), 340–344.

    Google Scholar 

  • Thurston, R. C., Blumenthal, J. A., Babyak, M. A., & Sherwood, A. (2005). Emotional antecedents of hot flashes during daily life. Psychosomatic Medicine, 67(1), 137–146.

    Article  Google Scholar 

  • Thurston, R. C., Blumenthal, J. A., Babyak, M. A., & Sherwood, A. (2006). Association between hot flashes, sleep complaints, and psychological functioning among healthy menopausal women. International Journal of Behavioral Medicine, 13(2), 163–172. doi:10.1207/s15327558ijbm1302_8

    Article  Google Scholar 

  • Thurston, R. C., Bromberger, J. T., Joffe, H., Avis, N. E., Hess, R., Crandall, C. J., et al. (2008a). Beyond frequency: Who is most bothered by vasomotor symptoms? Menopause, 15(5), 841–847.

    Article  Google Scholar 

  • Thurston, R. C., Chang, Y., Mancuso, P., & Matthews, K. A. (2013). Adipokines, adiposity, and vasomotor symptoms during the menopause transition: Findings from the Study of Women’s Health Across the Nation. Fertility and Sterility, 100(3), 793–800. doi:10.1016/j.fertnstert.2013.05.005

    Article  Google Scholar 

  • Thurston, R. C., Christie, I. C., & Matthews, K. A. (2010). Hot flashes and cardiac vagal control: A link to cardiovascular risk? Menopause, 17(3), 456–461.

    Google Scholar 

  • Thurston, R. C., Christie, I. C., & Matthews, K. A. (2012a). Hot flashes and cardiac vagal control during women’s daily lives. Menopause, 19(4), 406.

    Article  Google Scholar 

  • Thurston, R. C., Hernandez, J., Del Rio, J. M., & De La Torre, F. (2011a). Support vector machines to improve physiologic hot flash measures: Application to the ambulatory setting. Psychophysiology, 48(7), 1015–1021. doi:10.1111/j.1469-8986.2010.01155.x

    Article  Google Scholar 

  • Thurston, R. C., & Joffe, H. (2011). Vasomotor symptoms and menopause: Findings from the Study of Women’s Health across the Nation. Obstetetrics and Gynecology Clinics of North America, 38(3), 489–501. doi:10.1016/j.ogc.2011.05.006

    Article  Google Scholar 

  • Thurston, R. C., Matthews, K. A., Hernandez, J., & De La Torre, F. (2009a). Improving the performance of physiologic hot flash measures with support vector machines. Psychophysiology, 46(2), 285–292. doi:10.1111/j.1469-8986.2008.00770.x

    Article  Google Scholar 

  • Thurston, R. C., Santoro, N., & Matthews, K. A. (2011b). Adiposity and hot flashes in midlife women: A modifying role of age. Journal of Clinical Endocrinology andMetabolism, 96(10), E1588–E1595. doi:10.1210/jc.2011-1082

    Article  Google Scholar 

  • Thurston, R. C., Santoro, N., & Matthews, K. A. (2012b). Are vasomotor symptoms associated with sleep characteristics among symptomatic midlife women? Comparisons of self-report and objective measures. Menopause, 19(7), 742.

    Article  Google Scholar 

  • Thurston, R. C., Sowers, M. R., Sternfeld, B., Gold, E. B., Bromberger, J., Chang, Y., et al. (2009b). Gains in body fat and vasomotor symptom reporting over the menopausal transition: The study of women’s health across the nation. American Journal of Epidemiology, 170(6), 766–774. doi:10.1093/aje/kwp203

    Article  Google Scholar 

  • Thurston, R. C., Sowers, M. R., Sutton-Tyrrell, K., Everson-Rose, S. A., Lewis, T. T., Edmundowicz, D., et al. (2008b). Abdominal adiposity and hot flashes among midlife women. Menopause, 15(3), 429–434. doi:10.1097/gme.0b013e1815879cf

    Article  Google Scholar 

  • Thurston, R. C., Sutton-Tyrrell, K., Everson-Rose, S. A., Hess, R., & Matthews, K. A. (2008c). Hot flashes and subclinical cardiovascular disease: Findings from the Study of Women’s Health Across the Nation Heart Study. Circulation, 118(12), 1234–1240. doi:10.1161/CIRCULATIONAHA.108.776823

    Article  Google Scholar 

  • Webster, J. G., Bahr, D. E., Shults, M. C., Grady, D. G., & Macer, J. (2007). A miniature sternal skin-attached hot flash recorder. In R. Magjarevic, & J. H. Nagel (Eds.), World Congress on Medical Physics and Biomedical Engineering 2006 (Vol. 14, pp. 676–679, IFMBE Proceedings). Berlin: Springer.

    Google Scholar 

  • Woodward, S., & Freedman, R. R. (1994). The thermoregulatory effects of menopausal hot flashes on sleep. Sleep, 17(6), 497–501.

    Google Scholar 

  • Woodward, S., Greville, H. W., & Freedman, R. R. (1995). Ventilatory response during menopausal hot flashes. Menopause, 2(2), 81–88.

    Article  Google Scholar 

  • Xu, H., Thurston, R. C., Matthews, K. A., Bryce, C. L., Hays, R. D., Kapoor, W. N., et al. (2012). Are hot flashes associated with sleep disturbance during midlife? Results from the STRIDE cohort study. Maturitas, 71(1), 34–38. doi:10.1016/j.maturitas.2011.10.003

    Article  Google Scholar 

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Acknowledgments

This work was supported NIH grants R01HL105647 and K24123565 (Thurston) and T32HL083825 (Fisher/Orchard).

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Fisher, W.I., Thurston, R.C. (2016). Hot Flashes: Phenomenology and Measurement. In: Sievert, L., Brown, D. (eds) Biological Measures of Human Experience across the Lifespan. Springer, Cham. https://doi.org/10.1007/978-3-319-44103-0_11

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