Abstract
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the USA. An estimated 93,000 and 40,000 people will be diagnosed with colon cancer and rectal cancer in 2015, leading to 50,000 deaths (Cancer facts and figures 2015. American Cancer Society, Atlanta, 2015). Most colorectal cancer patients die of metastatic disease. The most common metastatic site of CRC is the liver. Sixty percent of CRC patients have liver metastases at the initial presentation or during their disease course. Liver-only disease is present in 30 % of patients (J Pathol 150:195–203, 1986). However, only 20 % of these patients are eligible for liver metastasis resection, which still offers the best chance of cure and increased overall survival (Ann Surg 232:763–776, 2000; Cancer 70:28–34, 1992; Cancer 115:752–759, 2009). Studies show that a significant percentage of patients with initially unresectable colorectal liver metastases after downstaging with chemotherapy to resectable can enjoy improved survival outcome and cure (J Clin Oncol 27:1829–1835, 2009). Most of the recurrences after liver section are in the liver. For these reasons, hepatic artery-directed therapy offers improving outcomes for these metastatic colorectal cancer patients (J Pathol 150:195–203, 1986).
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Cho, M., Leong, L.A. (2017). Hepatic Artery Infusion (HAI) for Colorectal Liver Metastases and Complications of HAI Pump. In: Fong, Y., Kauffmann, R., Marcinkowski, E., Singh, G., Schoellhammer, H. (eds) Surgical Emergencies in the Cancer Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-44025-5_29
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