Abstract
The complex organization of the brain into neural networks allows for rapid adaption and plasticity necessary for learning and memory. Recent evidence supports the notion that in neurodegenerative disorders behavioral alterations are associated with network dysfunction. The objective of this chapter is to provide an overview of the structure and organization of the nervous system into networks relevant to the understanding of the pathogenesis of Alzheimer’s disease, Parkinson’s disease, HIV neurocognitive impairment and other neurodegenerative and neuroinflammatory disorders. The chapter also provides a summary of the nervous system unique circulatory organization and interactions between neural and vascular activity that accounts for the mechanisms regulating the trafficking of immune cells from peripheral tissues. This chapter provides the structural framework for the better understanding of these interactions under physiological conditions and in neurological diseases.
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Acknowledgments
The author would like to thanks Ms. Maria Alonso for invaluable help preparing this chapter. The author is supported by NIH grants AG5131, AG18440, MH6512 and MH62962.
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Masliah, E. (2017). Anatomical Networks: Structure and Function of the Nervous System. In: Ikezu, T., Gendelman, H. (eds) Neuroimmune Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-44022-4_7
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DOI: https://doi.org/10.1007/978-3-319-44022-4_7
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